A major challenge in neuroscience is capturing and manipulating neuronal signaling and modulation both with high spatiotemporal resolution and across a large brain volume. Another significant hurdle lies in the lack of reagents to selectively target misfolded a-synuclein (a-syn) protein aggregates, a hallmark feature observed in various neurodegenerative diseases, including Parkinson’s disease and Lewy body dementia.
To address both of these challenges, the Wang research group takes a chemical biology approach to design novel classes of protein-based sensors, tools and reagents as described below.