Jiandie Lin Lab

We investigate the mechanisms that regulate nutrient and energy metabolism, and how they become reprogrammed in obesity and metabolic diseases.

Our Research

Our laboratory investigates the mechanisms that regulate nutrient and energy metabolism in cells, tissues, and organisms.

We focus on elucidating how the metabolic properties of tissues are specified during development and reprogrammed in disease, dissecting the genetic and epigenetic mechanisms of metabolic regulation, and discovering novel secreted factors in systemic metabolic crosstalk.

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Jiandie Lin, Ph.D.

Bradley M. Patten Collegiate Professor in the Life Sciences

Research Professor, U-M Life Sciences Institute

Professor of Cell and Developmental Biology, U-M Medical School

(734) 615-3512

[email protected]

Full Profile

Research

Lab Members

Publications

Publication Highlights

Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis

Zhao XY, Xiong X, Liu T, Mi L, Peng X, Rui C, Guo L, Li S, Li X, Lin JD, Nat Commun (2018)

Hepatic neuregulin 4 signaling defines an endocrine checkpoint for steatosis-to-NASH progression

Guo L, Zhang P, Chen Z, Xia H, Li S, Zhang Y, Kobberup S, Zou W, Lin JD, J Clin Invest. (2017)

Glucose Sensing by Skeletal Myocytes Couples Nutrient Signaling to Systemic Homeostasis

Meng ZX, Gong J, Chen Z, Sun J, Xiao Y, Wang L, Li Y, Liu J, Xu XZS, Lin JD, Mol Cell (2017)

The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuating hepatic lipogenesis

Wang GX, Zhao XY, Meng ZX, Kern M, Dietrich A, Zhou D, Okunade AL, Su X, Li S, Bluher M, Lin JD, Nat Med (2014)

A long noncoding RNA transcriptional regulatory circuit drives thermogenic adipocyte differentiation

Zhao XY, Li S, Wang GX, Yu Q, Lin JD, Mol Cell (2014)

BAF60c drives glycolytic muscle formation and improves glucose homeostasis through Deptor-mediated AKT activation

Meng ZX, Li S, Ko HJ, Lee Y, Okutsu M, Yan Z, Kim JK, Lin JD, Nat Med (2013)

View All Publications on PubMed

Jiandie Lin Lab

Our Research

Jiandie Lin, Ph.D.

News

New understanding of immune cells’ role in driving liver disease points to a potential therapeutic target for NASH

Researchers identify a hormone from fat cells that reprogram the liver microenvironment and restrain tumor growth in mice

When untethered, this signaling protein intensifies inflammation in obese mice, new study reveals

Publication Highlights

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