Publications

Publications

+co-first authors;  *co-corresponding authors

>>View a full list of publications on PubMed

2024

  • Cai, W+, Zhang, W,+, Zheng, Q+, Hor, C.C., Pan, T, Fatima, F, Dong, X, Duan, B*, and Xu, X.Z.S.* (2024) The kainate receptor GluK2 mediates cold sensing in mice.  Nature Neuroscience 27, 679-88 (cover story)    https://doi.org/10.1038/s41593-024-01585-8

2023

  • Wang, C.+, Ronan, E.A.+, Kim, S.K., Kitsopoulos, P., Iliff, A.J., Grosh, K., Kim, G.H., Liu, J., and Xu, X.Z.S. (2023) Sensing of sound pressure gradients by C. elegans drives phonotaxis behavior.  Current Biology 33, 3985-91.
  • Zhang, X., and Xu, X.Z.S. (2023) Electroreception: Worms leap to insects for dispersal. Current Biology 33, R775-7(dispatch)
  • Xiao, R.*, Liu, J., and Xu, X.Z.S.* (2023) Mechanosensitive GPCRs and ion channels in shear stress sensing.  Current Opinion in Cell Biology 84, 102216 (review)
  • Li, Z.+*, Zhou, J.+, Wani K.A.+, Yu, T., Ronan, E.A., Piggott, B.J., Liu, J., and Xu, X.Z.S.* (2023) A C. elegans neuron both promotes and suppresses motor behavior to fine tune motor output.  Frontiers in Molecular Neuroscience 16, 1228980.

2022

  • Zhang, X.+, Liu, J.+, Pan, T., Ward, A., Liu, J., and Xu, X.Z.S. (2022) A cilia-independent function of BBSome mediated by DLK-MAPK signaling in C. elegans photosensation.   Developmental Cell 57, 1545–1557 (cover story)
  • Li, Z.*, and Xu, X.Z.S.* (2022) Chemosensation: Corollary discharge filters out self-generated chemical cues. Current Biology 32, R788-90(dispatch)   
  • Zhang, X., and Xu, X.Z.S. (2023) Electroreception: Worms leap to insects for dispersal. Current Biology 33, R775-7(dispatch)
  • Zheng, T.+, Luo, Q.+, Han, C., Zhou, J., Gong, J., Chun, L., Xu, X.Z.S., and Liu, J. (2022) Cytoplasmic and mitochondrial aminoacyl-tRNA synthetases differentially regulate lifespan in Caenorhabditis elegans. iScience  25,105266

2021

  • Iliff, A.J.+, Wang, C.+, Ronan, E.A., Hake, A.E., Guo, Y., Li, X., Zhang, X., Zheng, M., Liu, J., Grosh, K., Duncan, R.K., Xu, X.Z.S. (2021) The nematode C. elegans senses airborne sound.  Neuron   109, 3633-46
  • Zhang, B., Jun, H., Wu, J., Liu, J.*, and Xu, X.Z.S.* (2021) Olfactory perception of food abundance regulates dietary restriction-mediated longevity via a brain-to-gut signal.      Nature Aging 1, 255–68 
  • Xiao, R.* and Xu, X.Z.S.* (2021) Temperature sensation: from molecular thermosensors to neural circuits and coding principles.  Annual Review of Physiology  83, 205-30 (review)
  • Ronan, E.A., Xiao, R.*, and Xu, X.Z.S.* (2021) TRP channels: Intestinal bloating TRiPs up pathogen avoidance.  Cell Calcium  98, 102446 (commentary)

2020

  • Zhang, W.+, He, F.+, Ronan, E.A., Liu, H., Gong, J., Liu, J.*, and Xu, X.Z.S.* (2020) Regulation of photosensation by hydrogen peroxide and antioxidants in C. elegans.  PLoS Genetics.  16(12):e1009257
  • Jun, H., Ma, Y., Chen, Y., Gong, J., Liu, S., Wang, J., Knights, A.J., Qiao, X., Emont, M.P.., Xu, X.Z.S., Kajimura, S, and Wu, J. (2020) Adrenergic-independent signaling via CHRNA2 regulates beige fat activation.  Developmental Cell  54, 106-16.
  • Iliff, A.J. and Xu, X.Z.S. (2020) C. elegans: a sensible model for sensory biology. Journal of Neurogenetics  34, 347-50 (perspective)
  • Alcedo, J., Jin, Y., Portman, D.S., Prahlad, V., Raizen, D., Rapti, G., Xu, X.Z.S., Zhang, Y., and Wu, C.F. (2020) Nature's gift to neuroscience. Journal of Neurogenetics. 34, 223-4 (editorial)
  • Ching, T.T., Chen, Y.C., Li. G., Liu, J., Xu, X.Z.S., and Hsu, A.L. (2020) Short-term enhancement of motor neuron synaptic exocytosis during early aging extends lifespan in Caenorhabditis elegans. Exp Biol Med, 245, 1552-59.

2019

  • Gong, J.+, Liu, J.+, Ronan, E.A.+, He, F.+, Cai, W., Fatima, M, Zhang, W., Lee, H., Li, Z., Kim, G.H., Pipe, K.P., Duan, B., Liu, J.*, and Xu, X.Z.S.* (2019) A cold-sensing receptor encoded by a glutamate receptor gene.  Cell  178, 1375-86
  • Pan, H., Fatima, M, Li, A., Lee, H., Cai, W., Horwitz, L., Hor, C.C., Zaher, N., Cin, M., Slade, H., Huang, T., Xu, X.Z.S., Duan, B. (2019) Identification of a spinal circuit for mechanical and persistent spontaneous itch.  Neuron 103, online on July 16
  • Xiong, X., Kuang, H., Ansari, S., Liu, T., Gong, J., Wang, S., Zhao, X.Y., Ji, Y., Li, C., Guo, L., Zhou, L., Chen, Z., Leon-Mimila, P., Chung, M.T., Kurabayashi, K., Opp, J., Campos-Pérez, F., Villamil-Ramírez, H., Canizales-Quinteros, S., Lyons, R., Lumeng, C.N., Zhou, B., Qi, L., Huertas-Vazquez, A., Lusis, A.J., Xu, X.Z.S, Li, S., Yu, Y., Li, J.Z., and Lin, J.D. (2019) Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis.  Molecular Cell  75, 644-660
  • Duan, B. and Xu, X.Z.S. (2019) How to break a fever: a feedback circuit for body temperature control.   Neuron 103, 79-81(preview)
  • Li, G.+, Gong, J.+, Liu, J., Li., H., Hsu, A.L., Liu, J.*, and Xu, X.Z.S.* (2019) Genetic and pharamcological interventions in the aging motor nervous system slow motor aging and extends life span in C. elegans.  Science Advances  5(1): eaau5041
  • Tao, L., Porto, D., Li, Z., Fechner, S., Lee, S.A., Goodman, M.B., Xu, X.Z.S., Lu, H., Shen, K. (2019) Parallel processing of two mechanosensory modalities by a single neuron in C. elegans.  Developmental Cell  51, 617-31

2018

  • Maeder, C.I., Kim, J.I., Liang, X., Kaganovsky, K., Shen, A., Li, Q., Li, Z., Wang, S., Xu, X.Z.S., Li, J.B., Xiang, Y.K., Ding, J.B., Shen, K. (2018) The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival.   Cell  174, 1436-49.
  • Jun, H., Yu, H., Gong, J., Jiang, J., Qiao, X., Perkey, E., Kim, D.I., Emont, M.P., Zestos, A.G., Cho, J.S., Liu, J., Kennedy, R.T., Maillard, I., Xu, X.Z.S., and Wu, J. (2018) An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling.  Nature Medicine 24, 814-22
  • Iliff, A.J., and Xu, X.Z.S. (2018) A mechanosensitive GPCR that detects the bloody force.  Cell 173, 542-4(preview).
  • Zhang, B.+, Gong, J.+, Zhang, W., Xiao, R., Liu, J.*, and Xu, X.Z.S.* (2018) Brain-gut communications via distinct neuroendocrine signals bi-directionally regulate longevity in C. elegans.  Genes & Development 32, 258-70

2017

  • Rauthan, M.+, Gong, J.+, Liu, J., Li, Z., Liu, J., and Xu, X.Z.S. (2017) microRNA regulation of nAChR expression and nicotine-dependent behavior in C. elegans.  Cell Reports  21, 1434-41
  • Meng, Z.X., Gong, J., Chen, Z., Sun, J., Xiao, Y., Wang, L., Li, Y., Liu, J., Xu X.Z.S., and Lin, J.D. (2017) Glucose sensing by skeletal myocytes couples nutrient signaling to systemic homeostasis.  Molecular Cell  66, 332-34 

2016

  • Gong, J., Yuan, Y., Ward, A., Kang, L., Zhang, B., Wu, Z., Peng, J., Feng, Z., Liu, J.*, and Xu, X.Z.S.* (2016) The C. elegans taste receptor homolog LITE-1 is a photoreceptor.  Cell  167, 1252-63.   PubMed link
  • Li, Z.+, Iliff, A.J.+, and Xu, X.Z.S. (2016) An elegant circuit for balancing risk and reward.  Neuron 92, 933-5(preview)
  • Li, G., Gong, J., Lei, H., Liu, J., and Xu, X.Z.S. (2016) Promotion of behavior and neuronal function by reactive oxygen species in C. elegans.   Nature Communications  7, 13234.  PubMed link
  • Chaudhuri, J., Bose, N., Gong, J., Hall, D., Rifkind, A., Bhaumik, D, Peiris, T.H., Chamoli, M., Le, C.H., Liu, J., Lithgow, G.J., Ramanathan, A., Xu, X.Z.S., and Kapahi, P. (2016) A Caenorhabditis elegans model elucidates a conserved role for TRPA1-Nrf signaling in reactive α-dicarbonyl detoxification.  Current Biology  26, 3014-25.  PubMed link
  • Wang, X.+, Li, G.+, Liu, J., Liu, J., and Xu, X.Z.S. (2016) TMC-1 mediates alkaline sensation in C. elegans via nociceptive neurons.  Neuron  91, 146-54.   PubMed link
  • Xu, X.Z.S. (2016) Demystifying mechanosensitive Piezo ion channels. Neuroscience Bulletin 32, 307-9(highlight).  PubMed link
  • Li, L., Lei, H., Arey, R.N., Li, P., Liu, J., Murphy, C.T.*, Xu, X.Z.S.*, and Shen, K.* (2016) The neuronal kinesin UNC-104/KIF1A is a key regulator of synaptic aging and insulin signaling-regulated memory and lifespan.  Current Biology  26, 605-15.   PubMed link
  • Wescott, S.A., Ronan, E.A., and Xu, X.Z.S. (2016) Insulin signaling genes modulate nicotine-induced behavioral responses in C. elegans. Behavioural Pharmacology  27, 44-49.   PubMed link

2015

  • Chun, L., Gong, J., Yuan, F., Zhang, B., Liu, H., Zheng, T., Yu, T., Xu, X.Z.S.*, and Liu, J.* (2015) Metabotropic GABA signalling modulates longevity in C. elegans.    Nature Communications 6, 8828.   PubMed link
  • Xiao, R. and Xu, X.Z.S. (2015) Thermosensation and longevity. J. of Comp. Physiol. A (review) 201, 857- 67.    PubMed link    
  • Hardaway, J.A., Whitaker, S.M., Snarrenberg, C.L., Li, Z., Xu, X.Z.S., Bermingham, D.P., Odiase, P., Spencer, W.C., Miller, D.M., Carvelli, L., Hardie, S.L., and Blakely, R.D. (2015) Glial expression of the Caenorhabditis elegans gene swip-10 supports glutamate dependent control of extrasynaptic dopamine signaling.  Journal of Neuroscience 35, 9409-23.   PubMed link 
  • Zhang, B., Xiao, R., Ronan, E.A., He, Y., Liu, J.*, and Xu, X.Z.S.* (2015) Environmental temperature differentially modulates C. elegans longevity through a thermosensitive TRP channel.  Cell Reports 11, 1414-24.   PubMed link 
  • Xiao, R., Chun, L., Ronan, E.A., Friedman, D.I., Liu, J., and Xu, X.Z.S. (2015) RNAi interrogation of dietary modulation of development, metabolism, behavior, and aging in C. elegans.  Cell Reports 11, 1123-33.   PubMed link    

2014

  • Yadlapalli, S.+, Wani, K.A.+, and Xu, X.Z.S. (2014) Past experience resets behavior: CaMK takes the heat.  Neuron  84, 883-885(preview).    PubMed link
  • Li, Z., Liu, J., Zheng, M., and Xu, X.Z.S. (2014) Encoding of both analog- and digital-like behavioral outputs by one C. elegans interneuron.  Cell  159, 751-765.  (cover story)   PubMed link

2013

  • Liu, J., Zhang, B., Feng, Z., Liu, J., Hsu, A.L., and Xu, X.Z.S. (2013) Functional aging in the nervous system contributes to age-dependent motor activity decline in C. elegans.  Cell Metabolism 18, 392-402.  (cover story)    PubMed link
  • Xiao, R., Zhang, B., Dong, Y., Gong, J., Xu, T., Liu, J., and Xu, X.Z.S. (2013) A genetic program promotes C. elegans longevity via a thermosensitive TRP channel.  Cell  152, 806-817. PubMed link
  • Wescott, S.A.+, Rauthan, M.+, and Xu, X.Z.S. (2013) When a TRP goes bad: Transient receptor potential channels in addiction.  Life Sciences (review) 92, 410-414. PubMed link

2012

  • Singaravelu, G., Chatterjee, I., Rahimi, S., Druzhinia, M.K., Kang, L., Xu, X.Z.S., and Singson, A. (2012) The sperm surface localization of the TRP-3/SPE-41 calcium channel depends on SPE-38 function in Caenorhabditis elegans.  Dev. Biol. 365, 376-83. PubMed link
  • Zheng, M., Cao, P., Yang, J., Xu, X.Z.S.*, and Feng, Z.* (2012). Calcium imaging of multiple neurons in freely-behaving C. elegans.  Journal of Neuroscience Methods 206, 78-82. PubMed link
  • Park, E.C., Ghose, P., Shao, Z., Ye, Q., Kang, L., Xu, X.Z.S., Powell-Coffman, J.A., Rongo, C. (2012). Oxygen levels regulate glutamate receptor trafficking through a HIF-independent mechanism.  EMBO Journal 31, 1379-93. PubMed link
  • Zhang, D., Isack, N.R., Glodowski, D.R., Liu, J., Chen, C.C., Xu, X.Z.S., Grant, B.D., Rongo, C. (2012). RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde transport pathway.  Journal of Cell Biology 196, 85-101. PubMed link

2011

  • Piggott, B.J.+, Liu, J.+, Feng, Z.+, Wescott, S.A., and Xu, X.Z.S. (2011). The neural circuits and synaptic mechanisms underlying motor initiation in C. elegans.  Cell  147, 922-933. PubMed link
  • Kang, L., Wescott, S., Li, W., and Xu, X.Z.S. (2011). In touch: the molecular basis of mechanosensory transduction.  The Biochemist 33, 18-20 (review).   PubMed link
  • Li, W., Piggott, B.J., Feng, Z., and Xu, X.Z.S. (2011). The neural circuits and sensory channels mediating harsh touch sensation in Caenorhabditis elegans.  Nature Communications  2, 315. PubMed link
  • Xiao, R., and Xu, X.Z.S. (2011). C. elegans TRP channels.  Advances in Exp. Med. & Biol. 704, 323-39 (review). PubMed link

2010

  • Xiao, R., and Xu, X.Z.S. (2010). Mechanosensitive channels: in touch with piezo.  Current Biology 20, R936-938 (dispatch). PubMed link
  • Wang GJ, Kang L, Kim JE, Maro GS, Xu, X.Z.S., and Shen, K. (2010). GRLD-1 regulates cell-wide abundance of glutamate receptor through post-transcriptional regulation.  Nature Neuroscience 13, 1489-1495. PubMed link
  • Kang, L.+, Gao, J.+, Schafer, W.R., Xie, Z., and Xu, X.Z.S. (2010). C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel.  Neuron  67, 381-391. PubMed link
  • Liu, J.+, Ward, A.+, Gao, J., Dong, Y., Nishio, N., Inada, H., Kang, L., Yu, Y., Ma, D., Xu, T., Mori, I., Xie, Z., and Xu, X.Z.S. (2010). C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog.  Nature Neuroscience  13, 715-722. PubMed link

2009

  • Ward, A., Walker, V.J., Feng, Z., and Xu, X.Z.S. (2009). Cocaine modulates locomotion behavior in C. elegans.  PLoS ONE  4, e5946. PubMed link
  • Xiao, R., and Xu, X.Z.S. (2009). Function and regulation of TRP family channels in C. elegans.  Pflugers Arch. 458, 851-60 (review). PubMed link

2008

  • Ward, A.+, Liu, J.+, Feng, Z., and Xu, X.Z.S. (2008). Light-sensitive neurons and channels mediate phototaxis in C. elegans.  Nature Neuroscience 11, 916-622. PubMed link
  • Hsu, A.L.*+, Feng, Z.+, Hsieh, M.Y., and Xu, X.Z.S.* (2008). Identification by machine vision of the rate of motor activity decline as a lifespan predictor in C. elegans.  Neurobiology of Aging 30, 1498-1503 [Epub Feb 5, 2008]. PubMed link

2006

  • Feng, Z.+, Li, W.+, Ward, A., Piggott, B.J., Larkspur, E., Sternberg, P.W., and Xu, X.Z.S. (2006). A C. elegans model of nicotine-dependent behavior: regulation by TRP-family channels.  Cell  127, 621-633. PubMed link
  • Li, W., Feng, Z., Sternberg, P.W., and Xu, X.Z.S. (2006). A C. elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologue.  Nature  440, 684-687. PubMed link

1998-2003

  • Xu, X.Z.S., & Sternberg, P.W. (2003). A C. elegans sperm TRP protein required for sperm-egg interactions during fertilization.  Cell  114, 285-297. PubMed link
  • Xu, X.Z.S., Moebius, F., Gill, D.L., & Montell, C. (2001). Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform.  Proc. Natl. Acad. Sci. USA 98, 10692-10697. PubMed link
  • Xu, X.Z.S., Chien, F., Butler, A., Salkoff, L., & Montell, C. (2000). TRP gamma, a Drosophila TRP-related subunit, forms a regulated cation channel with TRPL.  Neuron 26, 647-657. PubMed link
  • Wes, P.D.+, Xu, X.Z.S.+, Li, H.S., Chien, F., Doberstein, S.K., and Montell, C. (1999). Termination of phototransduction requires binding of the NINAC myosin III and the PDZ protein INAD.  Nature Neuroscience 2, 447-453. PubMed link
  • Li, H.S., Xu, X.Z.S., & Montell, C. (1999). Activation of a TRPC3-dependent cation current through the neurotrophin BDNF.  Neuron  24, 261-273. PubMed link
  • Xu, X.Z.S., Wes, P.D., Chen, H., Li, H.S., Yu, M.J., Morgen, S., Liu, Y., & Montell, C. (1998). Retinal targets for calmodulin include proteins implicated in synaptic transmission.  J. Biol. Chem. 273, 31297-31307. PubMed link
  • Xu, X.Z.S., Choudhury, A., Li, X. L., & Montell, C. (1998). Coordination of an array of signaling proteins through homo- and heteromeric interactions between PDZ domains and target proteins.  J. Cell Biol. 142, 545-555. PubMed link
  • Xu, X.Z.S.+, Li, H.S.+, Guggino, W.B., & Montell, C. (1997). Coassembly of TRP and TRPL produces a distinct store-operated conductance.  Cell  89, 1155-1164. PubMed link