A basic biological question leads to the first FDA-approved treatment for rare blood disorder
The recently FDA-approved TAK-755 treatment for a rare but potentially lethal blood disorder arose from a fundamental biological question that piqued the interest of scientist in the Ginsburg lab at U-M.
Acrylic genetics: When scientific research becomes a work of art
When Kärt Tomberg joined the Ginsburg lab at the LSI, she planned to identify the genetic factors that play a role in a fatal blood clotting disease. Now, the culmination of that project is featured in the September 2018 issue of PLOS Genetics, not just as a research study, but as art.
Sending one gene to pinch hit for its twin may offer possible treatment for a type of congenital anemia
A team of U-M researchers has found that two paralog genes — which can lead to two very different diseases — are functionally nearly identical. The findings indicate that one gene could be harnessed to help treat the disease associated with the other.
Pure Science, Pure Michigan
In the last century, Michigan was a driving engine of America’s manufacturing economy. Today, programs like the Perrigo Undergraduate Fellowship at the LSI are helping to fuel a new knowledge-based economy in the state.
Trapping PCSK9 to lower cholesterol
Targeting the transport mechanism for a destructive protein lowers blood cholesterol levels in mice.