Michael Cianfrocco Lab
We investigate the molecular details that determine how, where and when motor proteins transport intracellular cargo to better understand their role in human health and disease.
Our research program focuses on the structural biology and biophysics underlying microtubule-based intracellular transport through cryo-electron microscopy, single-molecule fluorescence and biochemistry.
Overarching questions of the lab:
- How is specificity determined between motor proteins and cargo?
- How are the activities of motor proteins regulated?
- How do pathogens hijack the microtubule transport machinery?
Along the way, we are leveraging artificial intelligence and cloud computing to improve cryo-electron microscopy data collection and analysis to streamline structure determination.
