Jay Brito Querido Lab
We use single-particle cryo-electron microscopy in combination with biochemical approaches to study how messenger RNA translation is regulated in human health and disease.
The process of translating messenger RNA (mRNA) into proteins must be tightly regulated. Our lab is focused particularly on how the process is initiated.
Using cryo-electron microscopy in combination with biochemical and genetic approaches, we study the role of a family of enzymes called DEAD-box helicases in the initiation of mRNA translation in humans, and how this initiation is regulated in health and disease.
