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2022
- Liu J, Carlson HA, Scott EE. The structure and characterization of human cytochrome P450 8B1 supports future drug design for nonalcoholic fatty liver disease and diabetes. J Biol Chem. DOI: 10.1016/j.jbc.2022.102344.
- Bart AG, Morias G, Vangala VR, Loadman PM, Pors K, Scott, EE. Cytochrome P450 binding and bioactivation of tumor-targeted duocarmycin agents. Drug Metab Dispos. DOI: 10.1124/dmd.121.000642.
- Lao Y , Skiba MA, Chun SW, Narayan ARH, Smith JL. Structural basis for control of methylation extent in polyketide synthase metal-dependent C-methyltransferases. ACS Chem Biol. DOI: 10.1021/acschembio.2c00085.
- Pham VV, Gao M, Meagher JL, Smith JL, D’Souza VM. A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA. Comms Bio. DOI: 0.1038/s42003-022-03734-w.
- Kelly AS, Shende V, Flynn A, Dan Q, Ye Y, Smith JL, Tsukamoto S, Sigman M, Sherman DH. Data science-driven analysis of substrate-permissive diketopiperazine reverse prenyltransferase NotF: Applications in protein engineering and cascade biocatalytic synthesis of (–)-eurotiumin. J Amer Chem Soc. DOI: 10.1021/jacs.2c06631.
- Cerqueira, FM, Photenhauer, AL, Doden, HL, Brown, AN, Abdel-Hamid, AM, Moraïs, S, Bayer, E, Wawrzak,Z, Cann, I, Ridlon, JM, Hopkins, J, Koropatkin, NM. Sas20 is a highly flexible starch-binding protein in the Ruminococcus bromii cell-surface amylosome. J Biol Chem. Doi: 10.1016/j.jbc.2022.101896.
- Kermani AA, Burata OE, Koff BB, Koide A, Koide S, Stockbridge RB. Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates. eLife. DOI: 10.7554/eLife.76766.
- Li B, Jo M, Liu J, Tian J, Canfield R, Bridwell-Rabb. Structural and mechanistic basis for redox sensing by the cyanobacterial transcription regulator RexT. Commun Biol. DOI: 10.1038/s42003-022-03226-x.
2021
- Biering SB, Akey DL, Wong MP, Brown WC, Lo NTN, Puerta-Guardo H, Tramontini Gomesde Sousa F, Wang C, Konwerski JR, Espinosa DA, Bockhaus NJ, GlasnerCR, Li J, Blanc SF, Juan EY, Elledge SJ, Mina MJ, Beatty PR, Smith JL, Harris E. Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction. Science. DOI: 10.1126/science.abc0.
- Park KS, Bazzill JD, Son S, Nam J, Shin SW, Ochyl LJ, Stuckey JA, Meagher JL, Chang L, Song J, Montefiori DC, LaBranche CC, Smith JL, Xu J, Moon JJ. Lipid-based vaccine nanoparticles for induction of humoral immune responses against HIV-1 and SARS-CoV-2. J Control Release. DOI:10.1016/j.jconrel.2020.12.031.
- Pinter TBJ, Ruckthong L, Stuckey JA, Deb A, Penner-Hahn JE, Pecoraro VL. Open reading frame 1 protein of the human long interspersed nuclear element 1 retrotransposon binds multiple equivalents of lead. J Am Chem Soc. DOI: 10.1021/jacs.1c06461.
- Rej RK, Wang C, Lu J, Wang M, Petrunak E, Zawacki KP, McEachern D, Yang CY, Wang L, Li R, Chinnaswamy K, Wen B, Sun D, Stuckey JA, Zhou Y, Chen J, Tang G, Wang S. Discovery of EEDi-5273 as an exceptionally potent and orally efficacious EED inhibitor capable of achieving complete and persistent tumor regression. J Med Chem. DOI: 10.1021/acs.jmedchem.1c01059.
- Zhou H, Lu J, Liu L, McEachern D, Yang C-Y, Bernard D, Chinnaswamy K, Stuckey J, Shen H, Rui L, Sun Y, Wang S. Selective Cullin-3 inhibition via covalent DCN1binding effectively protects mice from Acetaminophen-induced liver toxicity. Nat Commun. DOI: 10.1038/s41467-021-22924-4.
2020
- Covés-Datson EM, King SR, Legendre M, Gupta A, Chan SM, Gitlin E, Kulkarni VV, Pantaleón García J, Smee DF, Lipka E, Evans SE, Tarbet EB, Ono A, Markovitz DM. A molecularly engineered antiviral banana lectin inhibits fusion and is efficacious against influenza virus infection in vivo. Proc Natl Acad Sci U S A. DOI: 10.1073/pnas.1915152117.
- Rej RK, Wang C, Lu J, Wang M, Petrunak E, Zawacki KP, McEachern D, Fernandez-Salas E, Yang CY, Wang L, Li R, Chinnaswamy K, Wen B, Sun D, Stuckey J, Zhou Y, Chen J, Tang G,Wang S. EEDi-5285: An exceptionally potent, efficacious, and orally active small-molecule inhibitor of embryonic ectoderm development. J Med Chem. DOI:10.1021/acs.jmedchem.0c00479.
- Skiba MA, Tran CL, Dan Q, Sikkema AP, Klaver Z, Gerwick WH, Sherman DH, Smith JL. Repurposing the GNAT fold in the initiation of polyketide biosynthesis. Structure. DOI: 10.1016/j.str/2019.11.004.
- Tolbert AE, Ervin CS, Ruckthong L, Paul TJ, Jayasinghe-Arachchige VM, Neupane KP, Stuckey JA, Prabhakar R, Pecoraro VL. Heteromeric three-stranded coiled coils designed using a Pb(II)(Cys)3template mediated strategy. Nat Chem. DOI:10.1038/s41557-020-0423-6.
