Saltiel Life Sciences Symposium 2024: Celebrating 20 Years of Impact

Schedule

Day 1: Monday, May 20, 2024

• 9:00 a.m. | Welcome 
  Mary Sue Coleman, Ph.D., President Emerita of the University of Michigan

• 9:15 a.m. | Mary Sue and Kenneth Coleman Life Sciences Lecture: 
  Genetics of hemostasis — From bedside to bench and back again
  David Ginsburg, M.D., U-M Life Sciences Institute

• 10:10 a.m. | Break

• 10:25 a.m | Session 1: Biological mechanisms at the finest scale — Insights from structural biology 
  Session Chair: Janet Smith, Ph.D., U-M Life Sciences Institute

  • Chasing G protein-coupled receptors with electron microscopy
    Georgios Skiniotis, Ph.D., Stanford University

  • Adapter control mechanisms of the p97/VCP AAA+ unfoldase
    Dan Southworth, Ph.D., University of California, San Francisco

  • Structural consequences of receptor barcoding by GRK2 and GRK5
    John Tesmer, Ph.D., Purdue University

  • Insights into neurodegeneration by in situ cryo-ET
    Shyamal Mosalaganti, Ph.D., U-M Life Sciences Institute

  • Structural basis of mRNA translation initiation and its regulation in eukaryotes
    Jay Brito Querido, Ph.D., U-M Life Sciences Institute

• 12:10 p.m. | LSI Alumni Talks — Structural Biology 
  Session Chair: Melanie Ohi, Ph.D., U-M Life Sciences Institute

  • Structural dynamics and specificity in RhoGEF signaling
    Jen Cash, Ph.D., University of California, Davis

  • Molecular mechanism of IgM
    Junyu Xiao, Ph.D., Peking University

• 12:45 p.m. | Lunch and Poster Session (View poster titles and authors)

• 2:15 p.m.| Session 2: Exploring the building blocks of life — Cell and developmental biology
  Session Chair: Chelsey Spriggs, Ph.D., U-M Life Sciences Institute

  • The hematopoietic stem cell niche: Implications for bone marrow transplantation and regeneration
    Sean Morrison, Ph.D., University of Texas Southwestern Medical Center

  • Satellite DNA divergence in speciation
    Yukiko Yamashita, Ph.D., Whitehead Institute, Massachusetts Institute of Technology

  • Neutrophil signaling during acute inflammation
    Carole Parent, Ph.D., U-M Life Sciences Institute

  • Why does receptor recycling between endosomes and the plasma membrane require multiple parallel pathways?
    Lois Weisman, Ph.D., U-M Life Sciences Institute

• 3:40 p.m. | Break

• 3:55 p.m. | The LSI at 20: Origin and Evolution of the Life Sciences Institute
  Moderator: Roger Cone, Ph.D., U-M Life Sciences Institute

  • Huda Akil, Ph.D., U-M Medical School

  • Liz Barry, J.D., Higher Education Consultant

  • Mary Sue Coleman, Ph.D., President Emerita of the University of Michigan

  • David Ginsburg, M.D., U-M Life Sciences Institute

  • Paul Meister, Liberty Lane Partners, LLC

  • Alan Saltiel, Ph.D., University of California, San Diego

  • David Walt, Ph.D., Wyss Institute at Harvard University, Brigham and Women’s Hospital

• 4:50 p.m. | Day 1 Closing Remarks
  Roger D. Cone, Ph.D.

Day 2: May 21, 2024

• 9:00 a.m. | Welcome 

• 9:10 a.m. | Session 3: From cells to systems — The physiology of health and disease
  Session Chair: Jun Wu, Ph.D., U-M Life Sciences Institute

  • New functions of Notch signaling in B and T cell immunity
    Ivan Maillard, M.D., Ph.D., University of Pennsylvania

  • TREM2+ macrophages at the crossroads of metabolic liver disease and cancer
    Jiandie Lin, Ph.D., U-M Life Sciences Institute

  • A new mechanism in the regulation of energy homeostasis
    Roger Cone, Ph.D., U-M Life Sciences Institute

• 10:15 a.m. | Break

• 10:45 a.m. | LSI Alumni Talks — Physiology 
  Session Chair: Ken Inoki, M.D., Ph.D., U-M Life Sciences Institute

  • Scrambling in membrane balance and metabolic homeostasis
    Xiao-Wei Chen, Ph.D., Peking University

  • Phasic/tonic glial GABA differentially transduce for olfactory adaptation and neuronal aging
    Lijun Kang, Ph.D., Zhejiang University

  • Fishing for novel diagnostics and therapeutics for blood and cardiovascular disorders
    Jordan Shavit, M.D., Ph.D., U-M Medical School

• 11:35 a.m. | Lunch Break

• 12:30 p.m. | Session 4: Untangling the complexity of the nervous system — New frontiers in neuroscience 
  Session Chair: Cheng-Yu Lee, Ph.D., U-M Life Sciences Institute

  • Decoding neuronal diversity: Tracking molecular changes along lineage progression
    Tzumin Lee, M.D., Ph.D., U-M Life Sciences Institute

  • Neural control circuits of breathing patterns
    Peng Li, Ph.D., U-M Life Sciences Institute

  • Protein-based sensors and tools for studying neuromodulatory systems
    Wenjing Wang, Ph.D., U-M Life Sciences Institute

  • How do we sense the world? Lessons from the worm
    Shawn Xu, Ph.D., U-M Life Sciences Institute

• 1:55 p.m.| Break 

• 2:05 p.m. | Session 5: Catalyzing discovery — Innovation at the intersection of chemistry and biology
  Session Chair: Anna Mapp, Ph.D., U-M Life Sciences Institute

  • (I’m still trying to) Target protein stability to treat neurodegenerative diseases
    Jason Gestwicki, Ph.D., University of California, San Francisco

  • Making connections between protein sequence space and chemical space
    Alison Narayan, Ph.D., U-M Life Sciences Institute 

  • Discovery and engineering of natural product molecules for drug discovery
    David Sherman, Ph.D., U-M Life Sciences Institute 

  • Ultrasensitive single-molecule detection platforms for biomarker discovery and beyond
    Connie Wu, Ph.D., U-M Life Sciences Institute

• 3:30 p.m. | Break

• 3:40 p.m. | Session 6: Computation & Artificial Intelligence in Life Sciences
  Session Chair: Jun Li, Ph.D., U-M Medical School

  • Mathematical and computational studies in human population genetics
    Noah Rosenberg, Ph.D., Stanford University (video)

  • AI-based behavioral analysis for life sciences
    Bing Ye, Ph.D., U-M Life Sciences Institute (video)

  • Algorithms to automate cryo-EM data collection
    Mike Cianfrocco, Ph.D., U-M Life Sciences Institute

• 4:40 p.m.| Closing Remarks