Publications

Recent Articles | Articles (1998-2004) | Articles (1991-1997) | Review Articles | Editorial Material | Notes

Recent Articles

Cheng, A., M. Zhang, M. S. Gentry, C. A. Worby, J. E. Dixon and A. R. Saltiel. (2007). A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease.Genes and Development 21(19):2399-409PubMed , PDF.

Zhang M., J. Liu, A. Cheng, S. M. DeYoung, and A. R. Saltiel. (2007). Identification of CAP as a Costameric Protein that Interacts with Filamin C.Mol. Biol. Cell. 18(12):4731-40. PubMed , PDF.

Chen, W.X., D. Leto, S.H. Chiang, Q. Wang and A. R. Saltiel. (2007). Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c. Developmental Cell 13(3):391-404. PubMed , PDF.

Lesniewski, L.A., S.E. Hosch, J.G. Neels,C. de Luca, M. Pashmforoush, C.N. Lumeng, S.H. Chiang, M. Scadeng, A.R. Saltieland J.M. Olefsky. (2007). Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nature Medicine E-Pub ahead of print PubMed.

Lumeng, C.N., Bodzin, J.L., Saltiel, A.R. (2007). Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 117 (1):175-84. . PubMed, PDF

Lumeng, C.N., Deyoung, S.M., Bodzin, J.L.,Saltiel, A.R.. (2007). Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes 56 (1):16-23.. PubMed, PDF

Lodhi, I.J., Chiang, S.H., Chang, L., Vollenweider, D., Watson R.T., Inoue, M., Pessin, J.E., Saltiel, A.R. (2007) Gapex-5, a Rab31 Guanine Nucleotide Exchange Factor that Regulates Glut4 Trafficking in Adipocytes. Cell Metab. 5 (1):59-72.. PubMed, PDF

Chang, L., Chiang, S-H, and Saltiel, A.R. (2007). TC10 is Required for Insulin-Stimulated Glucose Uptake in Adipocytes. Endocrinology 148(1):27-33. PubMed, PDF

Lumeng, C.N., DeYoung, S.M. and Saltiel, A.R. (2007). Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins. Am. J. Physiol. 292(1):E166-74. PubMed, PDF

Zhang, M., Liu, J., DeYoung, S.M., Cheng, A., Chen, X-W, Dold, L.H. and Saltiel, A.R. (2006). CAP interacts with cytoskeletal proteins and regulates adhesion-mediated ERK activation and motility. EMBO J. 25(22):5284-93. PubMed, PDF

Chen, X-W, Inoue, M., Hsu, S-C and Saltiel, A.R. (2006). RalA-exocyst dependent recycling endosome trafficking is required for the completion of cytokinesis. J. Biol. Chem. 281(50):38609-16. PubMed, PDF

Su, X. Lodhi, I.J., Saltiel, A.R. and Stahl, P.D. (2006). Insulin-stimulated interaction between insulin receptor substrate-1 and p85 and activation of protein kinase B/Akt require Rab5. J. Biol. Chem. 281, 27982-90. PubMed, PDF

Kawase, K., Nakamura, T., Takaya, A., Aoki, K., Namikawa, K., Kiyama, H., Inagaki, S., Takemoto, H., Saltiel, A.R. and Matsuda, M (2006). Down Regulation of TC10 Activity Precedes Vesicular Fusion” (2006) Developmental Cell 11, 411-421 PubMed

Chun, T. H., Hotary, K. B., Sabeh, F., Saltiel, A. R., Allen, E. D., & Weiss, S. J. (2006). A pericellular collagenase directs the 3-dimensional development of white adipose tissue. Cell, 125, 577-591. PubMed

Cheng, A., Zhang, M., Crosson, S. M., Bao, Z. Q., & Saltiel, A. R. (2006). Regulation of the mouse protein targeting to glycogen (PTG) promoter by the FoxA2 forkhead protein and by 3',5'-cyclic adenosine 5'-monophosphate in H4IIE hepatoma cells. Endocrinology, 147, 3606-3612. PubMed, PDF

Inoue, M., Chiang, S. H., Chang, L., Chen, X. W., & Saltiel, A. R. (2006). Compartmentalization of the exocyst complex in lipid rafts controls Glut4 vesicle tethering. Molecular Biology of the Cell, 17, 2303-2311. PubMed, PDF

Liu, J., DeYoung, S. M., Zhang, M., Dold, L. H., & Saltiel, A. R. (2005). The stomatin/prohibitin/flotillin/HflK/C domain of flotillin-1 contains distinct sequences that direct plasma membrane localization and protein interactions in 3T3-L1 adipocytes. Journal of Biological Chemistry, 280, 16125-16134. PubMed,

Liu, J., DeYoung, S. M., Zhang, M., Zhang, M., Cheng, A., & Saltiel, A. R. (2005). Changes in integrin expression during adipocyte differentiation. Cell Metabolism, 2, 165-177. PubMed

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Articles (1998-2004)

Voisine, P., Ruel, M., Khan, T. A., Bianchi, C., Xu, S. H., Kohane, I., Libermann, T. A., Otu, H., Saltiel, A. R., & Sellke, F. W. (2004). Differences in gene expression profiles of diabetic and nondiabetic patients undergoing cardiopulmonary bypass and cardioplegic arrest. Circulation, 110 (Suppl S), I1280-I1286. PubMed

Kanzaki, M., Mora, S., Hwang, J. B., Saltiel, A. R., & Pessin, J. E. (2004). Atypical protein kinase C (PKC zeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3'-kinase and TC10 signaling pathways. Journal of Cell Biology, 164, 279-290. PubMed

Chang, L., Chiang, S. H., & Saltiel, A. R. (2004). Insulin signaling and the regulation of glucose transport. Molecular Medicine, 10, 65-71. PubMed

Chiang, S. H., Hwang, J., Legendre, M., Zhang, M., Kimura, A., & Saltiel, A. R. (2003). TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport. EMBO Journal, 22, 2679-2691. PubMed

Liu, J., DeYoung, S. M., Hwang, J. B., O'Leary, E. E., & Saltiel, A. R. (2003). The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport. Journal of Biological Chemistry, 278, 36754-36762. PubMed

Crosson, S. M., Khan, A., Printen, J., Pessin, J. E., & Saltiel, A. R. (2003). PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance. Journal of Clinical Investigation, 111, 1423-1432. PubMed

Watson, R. T., Furukawa, M., Chiang, S. H., Boeglin, D., Kanzaki, M., Saltiel, A. R., & Pessin, J. E. (2003). The exocytotic trafficking of TC10 occurs through both classical and nonclassical secretory transport pathways in 3T3-L1 adipocytes. Molecular and Cellular Biology, 23, 961-974. PubMed

Hu, J. J., Liu, J., Ghirlando, R., Saltiel, A. R., & Hubbard, S. R. (2003). Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Molecular Cell, 12, 1379-1389. PubMed

Zhang, M., Kimura, A., & Saltiel, A. R. (2003). Cloning and characterization of Cbl-associated protein splicing Isoforms. Molecular Medicine, 9, 18-25. PubMed

Inoue, M., Chang, L., Hwang, J., Chiang, S. H., & Saltiel, A. R. (2003). The exocyst complex is required for targeting of GLUT4 to the plasma membrane by insulin. Nature, 422, 629-633. PubMed

Chiang, S. H., Hou, J. C., Hwang, J., Pessin, J. E., & Saltiel, A. R. (2002). Cloning and functional characterization of related TC10 isoforms, a subfamily of rho proteins involved in insulin-stimulated glucose transport. Journal of Biological Chemistry, 277, 13067-13073. PubMed

Kimura, A., Mora, S., Shigematsu, S., Pessin, J. E., & Saltiel, A. R. (2002). The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1. Journal of Biological Chemistry, 277, 30153-30158. [Correction 277, 40167.] PubMed

Liu, J., Kimura, A., Baumann, C. A., & Saltiel, A. R. (2002). APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes. Molecular and Cellular Biology, 22, 3599-3609. PubMed

Kanzaki, M., Watson, R. T., Hou, J. C. Q., Stamnes, M., Saltiel, A. R., & Pessin, J. E. (2002). Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3-L1 adipocytes. Molecular Biology of the Cell, 13, 2334-2346. PubMed

Chang, L., Adams, R. D., & Saltiel, A. R. (2002). The TC10-interacting protein CIP4/2 is required for insulin-stimulated GLUT4 translocation in 3T3-L1 adipocytes. Proceedings of the National Academy of Sciences of the USA, 99, 12835-12840.

Skinner, J. A., & Saltiel, A. R. (2001). Cloning and identification of MYPT3: A prenylatable myosin targeting subunit of protein phosphatase 1. Biochemical Journal, 356, 257-267.

Baumann, C. A., Brady, M. J., & Saltiel, A. R. (2001). Activation of glycogen synthase by insulin in 3T3-L1 adipocytes involves c-Cbl-associating protein (CAP)-dependent and CAP-independent signaling pathways. Journal of Biological Chemistry, 276, 6065-6068. PubMed

Watson, R. T., Shigematsu, S., Chiang, S. H., Mora, S., Kanzaki, M., Macara, I. G., Saltiel, A. R., & Pessin, J. E. (2001). Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation. Journal of Cell Biology, 154, 829-840. PubMed

Chiang, S. H., Baumann, C. A., Kanzaki, M., Thurmond, D. C., Watson, R. T., Neudauer, C. L., Macara, I. G., Pessin, J. E., & Saltiel, A. R. (2001). Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10. Nature, 410, 944-948. PubMed

Kimura, A., Baumann, C. A., Chiang, S. H., & Saltiel, A. R. (2001). The sorbin homology domain: A motif for the targeting of proteins to lipid rafts. Proceedings of the National Academy of Sciences of the USA, 98, 9098-9103. PubMed

Newgard, C. B., Brady, M. J., O'Doherty, R. M., & Saltiel, A. R. (2000). Organizing glucose disposal - Emerging roles of the glycogen targeting subunits of protein phosphatase-1. Diabetes, 49, 1967-1977. PubMed

Baumann, C. A., Chokshi, N., Saltiel, A. R., & Ribon, V. (2000). Cloning and characterization of a functional peroxisome proliferator activator receptor-gamma-responsive element in the promoter of the CAP gene. Journal of Biological Chemistry, 275, 9131-9135. PubMed

Fong, N. M., Jensen, T. C., Shah, A. S., Parekh, N. N., Saltiel, A. R., & Brady, M. J. (2000). Identification of binding sites on protein targeting to glycogen for enzymes of glycogen metabolism. Journal of Biological Chemistry, 275, 35034-35039. PubMed

Saltiel, A. R. (2000). The molecular and physiological basis of insulin resistance: Emerging implications for metabolic and cardiovascular diseases - Series introduction. Journal of Clinical Investigation, 106, 163-164. PubMed

Pessin, J. E., & Saltiel, A. R. (2000). Signaling pathways in insulin action: Molecular targets of insulin resistance. Journal of Clinical Investigation, 106, 165-169. PubMed

Baumann, C. A., Ribon, V., Kanzaki, M., Thurmond, D. C., Mora, S., Shigematsu, S., Bickel, P. E., Pessin, J. E., & Saltiel, A. R. (2000). CAP defines a second signaling pathway required for insulin-stimulated glucose transport. Nature, 407, 202-207. PubMed

Hansen, L., Fjordvang, H., Rasmussen, S. K., Vestergaard, H., Echwald, S. M., Hansen, T., Alessi, D., Shenolikar, S., Saltiel, A. R., Barbetti, F., & Pedersen, O. (1999). Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin - Lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients. Diabetes, 48, 403-407. PubMed

Nakashima, N., Rose, D. W., Xiao, S., Egawa, K., Martin, S. S., Haruta, T., Saltiel, A. R., & Olefsky, J. M. (1999). The functional role of CrkII in actin cytoskeleton organization and mitogenesis. Journal of Biological Chemistry, 274, 3001-3008. PubMed

Kao, A. W., Noda, Y., Johnson, J. H., Pessin, J. E., & Saltiel, A. R. (1999). Aldolase mediates the association of F-actin with the insulin-responsive glucose transporter GLUT4. Journal of Biological Chemistry, 274, 17742-17747. PubMed

Brady, M. J., Kartha, P. M., Aysola, A. A., & Saltiel, A. R. (1999). The role of glucose metabolites in the activation and translocation of glycogen synthase by insulin in 3T3-L1 adipocytes. Journal of Biological Chemistry, 274, 27497-27504. PubMed

Min, J., Okada, S., Kanzaki, M., Elmendorf, J. S., Coker, K. J., Ceresa, B. P., Syu, L. J., Noda, Y., Saltiel, A. R., & Pessin, J. E. (1999). Synip: A novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes. Molecular Cell, 3, 751-760. PubMed

Syu, L. J., & Saltiel, A. R. (1999). Lipotransin: A novel docking protein for hormone-sensitive lipase. Molecular Cell, 4, 109-115. PubMed

Sebolt-Leopold, J. S., Dudley, D. T., Herrera, R., Van Becelaere, K., Wiland, A., Gowan, R. C., Tecle, H., Barrett, S. D., Bridges, A., Przybranowski, S., Leopold, W. R., & Saltiel, A. R. (1999). Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nature Medicine, 5, 810-816. PubMed

Su, T. Z., Wang, M., Oxender, D. L., & Saltiel, A. R. (1998). Troglitazone increases system A amino acid transport in 3T3-L1 cells. Endocrinology, 139, 832-837. PubMed

Su, T. Z., Wang, M. H., Syu, L. J., Saltiel, A. R., & Oxender, D. L. (1998). Regulation of system A amino acid transport in 3T3-L1 adipocytes by insulin. Journal of Biological Chemistry, 273, 3173-3179. PubMed

Ribon, V., Herrera, R., Kay, B. K., & Saltiel, A. R. (1998). A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions. Journal of Biological Chemistry, 273, 4073-4080. PubMed

Brady, M. J., Bourbonais, F. J., & Saltiel, A. R. (1998). The activation of glycogen synthase by insulin switches from kinase inhibition to phosphatase activation during adipogenesis in 3T3-L1 cells. Journal of Biological Chemistry, 273, 14063-14066. PubMed

Downey, G. P., Butler, J. R., Tapper, H., Fialkow, L., Saltiel, A. R., Rubin, B. B., & Grinstein, S. (1998). Importance of MEK in neutrophil microbicidal responsiveness. Journal of Immunology, 160, 434-443. PubMed

Desdouits-Magnen, J., Desdouits, F., Takeda, S., Syu, L. J., Saltiel, A. R., Buxbaum, J. D., Czernik, A. J., Nairn, A. C., & Greengard, P. (1998). Regulation of secretion of Alzheimer amyloid precursor protein by the mitogen-activated protein kinase cascade. Journal of Neurochemistry, 70, 524-530. PubMed

Mastick, C. C., Brady, M. J., Printen, J. A., Ribon, V., & Saltiel, A. R. (1998). Spatial determinants of specificity in insulin action. Molecular and Cellular Biochemistry, 182, 65-71. PubMed

Ribon, V., Printen, J. A., Hoffman, N. G., Kay, B. K., & Saltiel, A. R. (1998). A novel, multifunctional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Molecular and Cellular Biology, 18, 872-879.

Ribon, V., Johnson, J. H., Camp, H. S., & Saltiel, A. R. (1998). Thiazolidinediones and insulin resistance: Peroxisome proliferator-activated receptor gamma activation stimulates expression of the CAP gene. Proceedings of the National Academy of Sciences of the USA, 95, 14751-14756. PubMed

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Articles (1991-1997)

Ribon, V., & Saltiel, A. R. (1997). Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes. Biochemical Journal, 324, 839-845. PubMed

Plummer, M. S., Lunney, E. A., Para, K. S., Shahripour, A., Stankovic, C. J., Humblet, C., Fergus, J. H., Marks, J. S., Herrera, R., Hubbell, S., Saltiel, A., & Sawyer, T. K. (1997). Design of peptidomimetic ligands for the pp60(src) SH2 domain. Bioorganic & Medicinal Chemistry, 5, 41-47. PubMed

Shahripour, A., Para, K. S., Plummer, M. S., Lunney, E. A., Holland, D. R., Rubin, J. R., Humblet, C., Fergus, J. H., Marks, J. S., Saltiel, A. R., & Sawyer, T. K. (1997). Structure-based design of novel, dipeptide ligands targeting the pp60(Src) SH2 domain. Bioorganic & Medicinal Chemistry Letters, 7, 1107-1112.

Stankovic, C. J., Surendran, N., Lunney, E. A., Plummer, M. S., Para, K. S., Shahripour, A., Fergus, J. H., Marks, J. S., Herrera, R., Hubbell, S. E., Humblet, C., Saltiel, A. R., Stewart, B. H., & Sawyer, T. K. (1997). The role of 4-phosphonodifluoromethyl- and 4-phosphono-phenylalanine in the selectivity and cellular uptake of SH2 domain ligands. Bioorganic & Medicinal Chemistry Letters, 7, 1909-1914.

Groskopf, J. C., Syu, L. J., Saltiel, A. R., & Linzer, D. I. H. (1997). Proliferin induces endothelial cell chemotaxis through a G protein-coupled, mitogen-activated protein kinase-dependent pathway. Endocrinology, 138, 2835-2840.

Parrizas, M., Saltiel, A. R., & LeRoith, D. (1997). Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways. Journal of Biological Chemistry, 272, 154-161. PubMed

Wartmann, M., Hofer, P., Turowski, P., Saltiel, A. R., & Hynes, N. E. (1997). Negative modulation of membrane localization of the Raf-1 protein kinase by hyperphosphorylation. Journal of Biological Chemistry, 272, 3915-3923. PubMed

Brady, M. J., Printen, J. A., Mastick, C. C., & Saltiel, A. R. (1997). Role of protein targeting to glycogen (PTG) in the regulation of protein phosphatase-1 activity. Journal of Biological Chemistry, 272, 20198-20204. PubMed

Mastick, C. C., & Saltiel, A. R. (1997). Insulin-stimulated tyrosine phosphorylation of caveolin is specific for the differentiated adipocyte phenotype in 3T3-L1 cells. Journal of Biological Chemistry, 272, 20706-20714. PubMed

Kim, B., Leventhal, P. S., Saltiel, A. R., & Feldman, E. L. (1997). Insulin-like growth factor-I-mediated neurite outgrowth in vitro requires mitogen-activated protein kinase activation. Journal of Biological Chemistry, 272, 21268-21273. PubMed

Brady, M. J., Nairn, A. C., & Saltiel, A. R. (1997). The regulation of glycogen synthase by protein phosphatase 1 in 3T3-L1 adipocytes - Evidence for a potential role for DARPP-32 in insulin action. Journal of Biological Chemistry, 272, 29698-29703. PubMed

Syu, L. J., Guan, K. L., & Saltiel, A. R. (1997). Inducible expression of a mutant form of MEK1 in Swiss 3T3 cells. Journal of Cellular Biochemistry, 67, 367-377. PubMed

O'Rourke, C. M., Davis, J. A., Saltiel, A. R., & Cornicelli, J. A. (1997). Metabolic effects of troglitazone in the Goto-Kakizaki rat, a non-obese and normolipidemic rodent model of non-insulin dependent diabetes mellitus. Metabolism - Clinical and Experimental, 46, 192-198. PubMed

Pircher, T. J., Flores-Morales, A., Mui, A. L. F., Saltiel, A. R., Norstedt, G., Gustafsson, J. A., & Haldosen, L. A. (1997). Mitogen-activated protein kinase kinase inhibition decreases growth hormone stimulated transcription mediated by STAT5. Molecular and Cellular Endocrinology, 133, 169-176. PubMed

Printen, J. A., Brady, M. J., & Saltiel, A. R. (1997). PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolism. Science, 275, 1475-1478.

Thornton, K. H., Mueller, W. T., McConnell, P., Zhu, G. C., Saltiel, A. R., & Thanabal, V. (1996). Nuclear magnetic resonance solution structure of the growth factor receptor-bound protein 2 Src homology 2 domain. Biochemistry, 35, 11852-11864. PubMed

Shahripour, A., Plummer, M. S., Lunney, E. A., Para, K. S., Stankovic, C. J., Rubin, J. R., Humblet, C., Fergus, J. H., Marks, J. S., Herrera, R., Hubbell, S. E., Saltiel, A. R., & Sawyer, T. K. (1996). Novel phosphotyrosine mimetics in the design of peptide ligands for pp60(Src) SH2 domain. Bioorganic & Medicinal Chemistry Letters, 6, 1209-1214.

Seely, B. L., Staubs, P. A., Reichart, D. R., Berhanu, P., Milarski, K. L., Saltiel, A. R., Kusari, J., & Olefsky, J. M. (1996). Protein tyrosine phosphatase 1B interacts with the activated insulin receptor. Diabetes, 45, 1379-1385. PubMed

Saltiel, A. R., & Olefsky, J. M. (1996). Thiazolidinediones in the treatment of insulin resistance and type II diabetes. Diabetes, 45, 1661-1669. PubMed

Martin, S. S., Rose, D. W., Saltiel, A. R., Klippel, A., Williams, L. T., & Olefsky, J. M. (1996). Phosphatidylinositol 3'-kinase is necessary and sufficient for insulin-stimulated stress fiber breakdown. Endocrinology, 137, 5045-5054. PubMed

Azpiazu, I., Saltiel, A. R., DePaoli-Roach, A. A., Lawrence, J. C. (1996). Regulation of both glycogen synthase and PHAS-I by insulin in rat skeletal muscle involves mitogen-activated protein kinase-independent and rapamycin-sensitive pathways. Journal of Biological Chemistry, 271, 5033-5039. PubMed

Ribon, V., & Saltiel, A. R. (1996). Nerve growth factor stimulates the tyrosine phosphorylation of endogenous Crk-II and augments its association with p130 (Cas) in PC-12 cells. Journal of Biological Chemistry, 271, 7375-7380. PubMed

Holt, K. H., Waters, S. B., Okada, S., Yamauchi, K., Decker, S. J., Saltiel, A. R., Motto, D. G., Koretzky, G. A., & Pessin, J. E. (1996). Epidermal growth factor receptor targeting prevents uncoupling of the Grb2-SOS complex. Journal of Biological Chemistry, 271, 8300-8306. PubMed

Sasaoka, T., Langlois, W. J., Bai, F., Rose, D. W., Leitner, J. W., Decker, S. J., Saltiel, A. R., Gill, G. N., Kobayashi, M., Draznin, B., & Ollefsky, J. M. (1996). Involvement of ErbB2 in the signaling pathway leading to cell cycle progression from a truncated epidermal growth factor receptor lacking the C-terminal autophosphorylation sites. Journal of Biological Chemistry, 271, 8338-8344.

Morrison, P., Saltiel, A. R., & Rosner, M. R. (1996). Role of mitogen-activated protein kinase kinase in regulation of the epidermal growth factor receptor by protein kinase C. Journal of Biological Chemistry, 271, 12891-12896. PubMed

Ribon, V., Hubbell, S., Herrera, R., & Saltiel, A. R. (1996). The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner. Molecular and Cellular Biology, 16, 45-52. PubMed

Sawada, T., Milarski, K. L., & Saltiel, A. R. (1995). Expression of a catalytically inert Syp blocks activation of MAP kinase pathway downstream of P21(RAS). Biochemical and Biophysical Research Communications, 214, 737-743. PubMed

Pang, L., Zheng, C. F., Guan, K. L., & Saltiel, A. R. (1995). Nerve growth factor stimulates a novel protein kinase in PC-12 cells that phosphorylates and activates mitogen-activated protein kinase kinase (MEK). Biochemical Journal, 307, 513-519. PubMed

Milarski, K. L., Lazar, D. F., Wiese, R. J., & Saltiel, A. R. (1995). Detection of a 60 kda tyrosine-phosphorylated protein in insulin-stimulated hepatoma cells that associates with the SH2 domain of phosphatidylinositol 3'-kinase. Biochemical Journal, 308, 579-583. PubMed

Jhun, B. H., Haruta, T., Meinkoth, J. L., Leitner, J. W., Draznin, B., Saltiel, A. R., Pang, L., Sasaoka, T., & Olefsky, J. M. (1995). Signal transduction pathways leading to insulin-induced early gene induction. Biochemistry, 34, 7996-8004. PubMed

Rani, C. S. S., Abe, A., Chang, Y., Rosenzweig, N., Saltiel, A. R., Radin, N. S., & Shayman, J. A. (1995). Cell-cycle arrest induced by an inhibitor of glucosylceramide synthase - Correlation with cyclin-dependent kinases. Journal of Biological Chemistry, 270, 2859-2867. PubMed

Wiese, R. J., Mastick, C. C., Lazar, D. F., & Saltiel, A. R. (1995). Activation of mitogen-activated protein kinase and phosphatidylinositol 3'-kinase is not sufficient for the hormonal stimulation of glucose uptake, lipogenesis, or glycogen synthesis in 3T3-L1 adipocytes. Journal of Biological Chemistry, 270, 3442-3446. PubMed

Yamauchi, K., Ribon, V., Saltiel, A. R., & Pessin, J. E. (1995). Identification of the major SHPTP2-binding protein that is tyrosine-phosphorylated in response to insulin. Journal of Biological Chemistry, 270, 17716-17722. PubMed

Lin, T. A., Kong, X. M., Saltiel, A. R., Blackshear, P. J., & Lawrence, J. C. (1995). Control of Phas-I by insulin in 3T3-L1 adipocytes - Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway. Journal of Biological Chemistry, 270, 18531-18538.

Seely, B. L., Reichart, D. R., Staubs, P. A., Jhun, B. H., Hsu, D., Maegawa, H., Milarski, K. L., Saltiel, A. R., & Olefsky, J. M. (1995). Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins P85, Syp, and GTPase-activating protein. Journal of Biological Chemistry, 270, 19151-19157. PubMed

Lazar, D. F., Wiese, R. J., Brady, M. J., Mastick, C. C., Waters, S. B., Yamauchi, K., Pessin, J. E., Cuatrecasas, P., & Saltiel, A. R. (1995). Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin. Journal of Biological Chemistry, 270, 20801-20807.

Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T., & Saltiel, A. R. (1995). PD-098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. Journal of Biological Chemistry, 270, 27489-27494. PubMed

Mastick, C. C., Brady, M. J., & Saltiel, A. R. (1995). Insulin stimulates the tyrosine phosphorylation of caveolin. Journal of Cell Biology, 129, 1523-1531. PubMed

Yamauchi, K., Milarski, K. L., Saltiel, A. R., & Pessin, J. E. (1995). Protein tyrosine phosphatase SHPTP2 is a required positive effector for insulin downstream signaling. Proceedings of the National Academy of Sciences of the USA, 92, 664-668. PubMed

Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J., & Saltiel, A. R. (1995). A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proceedings of the National Academy of Sciences of the USA, 92, 7686-7689. PubMed

Maclean, D., Sefler, A. M., Zhu, G. C., Decker, S. J., Saltiel, A. R., Singh, J., McNamara, D., Dobrusin, E. M., & Sawyer, T. K. (1995). Differentiation of peptide molecular recognition by phospholipase c-gamma-1 Src homology 2 domain and a mutant Tyr phosphatase PTP1B(C215S). Protein Science, 4, 13-20. PubMed

Zheng, C. F., Ohmichi, M., Saltiel, A. R., & Guan, K. L. (1994). Growth factor induced MEK activation is primarily mediated by an activator different from C-Raf. Biochemistry, 33, 5595-5599. PubMed

Gergel, J. R., McNamara, D. J., Dobrusin, E. M., Zhu, G. C., Saltiel, A. R., & Miller, W. T. (1994). Identification of amino acids in the N terminal SH2 domain of phospholipase c-gamma-1 important in the interaction with epidermal growth factor receptor.

Mastick, C. C., Kato, H., Roberts, C. T., Leroith, D., & Saltiel, A. R. (1994). Insulin and insulin-like growth factor I receptors similarly stimulate deoxyribonucleic acid synthesis despite differences in cellular protein tyrosine phosphorylation. Endocrinology, 135, 214-222. PubMed

Misek, D. E., & Saltiel, A. R. (1994). An inositol phosphate glycan derived from a Trypanosoma brucei glycosyl phosphatidylinositol promotes protein dephosphorylation in rat epididymal adipocytes. Endocrinology, 135, 1869-1876. PubMed

Ohmichi, M., Matuoka, K., Takenawa, T., & Saltiel, A. R. (1994). Growth factors differentially stimulate the phosphorylation of SHC proteins and their association with GRB2 in PC-12 pheochromocytoma cells. Journal of Biological Chemistry, 269, 1143-1148. PubMed

Ohmichi, M., Sawada, T., Kanda, Y., Koike, K., Hirota, K., Miyake, A., & Saltiel, A. R. (1994). Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways - Evidence of a role for early tyrosine phosphorylation. Journal of Biological Chemistry, 269, 3783-3788. PubMed

Pang, L., Milarski, K. L., Ohmichi, M., Takata, Y., Olefsky, J. M., & Saltiel, A. R. (1994). Mutation of the 2-carboxyl terminal tyrosines in the insulin receptor results in enhanced activation of mitogen-activated protein kinase. Journal of Biological Chemistry, 269, 10604-10608. PubMed

Sasaoka, T., Rose, D. W., Jhun, B. H., Saltiel, A. R., Draznin, B., & Olefsky, J. M. (1994). Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor I, and epidermal growth factor. Journal of Biological Chemistry, 269, 13689-13694. PubMed

Milarski, K. L., & Saltiel, A. R. (1994). Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin. Journal of Biological Chemistry, 269, 21239-21243. PubMed

Staubs, P. A., Reichart, D. R., Saltiel, A. R., Milarski, K. L., Maegawa, H., Berhanu, P., Olefsky, J. M., & Seely, B. L. (1994). Localization of the insulin receptor binding sites for the SH2 domain proteins P85, Syp, and GAP. Journal of Biological Chemistry, 269, 27186-27192. PubMed

Pandey, A., Lazar, D. F., Saltiel, A. R., & Dixit, V. M. (1994). Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3'-kinase activity. Journal of Biological Chemistry, 269, 30154-30157. PubMed

Jhun, B. H., Rose, D. W., Seely, B. L., Rameh, L., Cantley, L., Saltiel, A. R., & Olefsky, J. M. (1994). Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-Fos expression. Molecular and Cellular Biology, 14, 7466-7475. PubMed

Ribon, V., Leff, T., & Saltiel, A. R. (1994). c-Myc does not require Max for transcriptional activity in PC-12 cells. Molecular and Cellular Neuroscience, 5, 277-282. PubMed

Lingwood, C. A., Sakac, D., & Saltiel, A. (1994). Developmentally regulated testicular galactolipid sulfotransferase inhibitor is a phosphoinositol glycerolipid and insulin mimetic. Molecular Reproduction and Development, 37, 462-466. PubMed

Zhu, G. C., Decker, S. J., Maclean, D., McNamara, D. J., Singh, J., Sawyer, T. K., & Saltiel, A. R. (1994). Sequence specificity in the recognition of the epidermal growth factor receptor by the abl Src homology 2 domain. Oncogene, 9, 1379-1385. PubMed

Rose, D. W., Saltiel, A. R., Majumdar, M., Decker, S. J., & Olefsky, J. M. (1994). Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction. Proceedings of the National Academy of Sciences of the USA, 91, 797-801. PubMed

Lazar, D. F., Knez, J. J., Medof, M. E., Cuatrecasas P., & Saltiel, A. R. (1994). Stimulation of glycogen synthesis by insulin in human erythroleukemia cells requires the synthesis of glycosyl-phosphatidylinositol. Proceedings of the National Academy of Sciences of the USA, 91, 9665-9669. PubMed

Pang, L., Lazar, D. F., Moller, D. E., Flier, J. S., & Saltiel, A. R. (1993). The stimulation of PP42(mapkinase) by insulin does not correlate with its metabolic actions in cells overexpressing mutant insulin-receptors. Biochemical and Biophysical Research Communications, 196, 301-310.

Pang, L., Decker, S. J., & Saltiel, A. R. (1993). Bombesin and epidermal growth factor stimulate the mitogen-activated protein kinase through different pathways in Swiss 3T3 cells. Biochemical Journal, 289, 283-287. PubMed

Ohmichi, M., Zhu, G. C., & Saltiel, A. R. (1993). Nerve growth factor activates calcium-insensitive protein kinase c-epsilon in PC-12 rat pheochromocytoma cells. Biochemical Journal, 295, 767-772. PubMed

Ohmichi, M., Pang, L., Ribon, V., Gazit, A., Levitzki, A., & Saltiel, A. R. (1993). The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor. Biochemistry, 32, 4650-4658. PubMed

Ohmichi, M., Pang, L., Ribon, V., & Saltiel, A. R. (1993). Divergence of signaling pathways for insulin in PC-12 pheochromocytoma cells. Endocrinology, 133, 46-56. PubMed

McNamara, D. J., Dobrusin, E. M., Zhu, G. C., Decker, S. J., & Saltiel, A. R. (1993). Inhibition of binding of phospholipase-c-gamma-1 sh2 domains to phosphorylated epidermal growth factor receptor by phosphorylated peptides. International Journal of Peptide and Protein Research, 42, 240-248. PubMed

Zhu, G. C., Decker, S. J., Mayer, B. J., & Saltiel, A. R. (1993). Direct analysis of the binding of the abl Src homology 2 domain to the activated epidermal growth factor receptor. Journal of Biological Chemistry, 268, 1775-1779. PubMed

Milarski, K. L., Zhu, G. C., Pearl, C. G., McNamara, D. J., Dobrusin, E. M., Maclean, D., Thiemesefler, A., Zhang, Z. Y., Sawyer, T., Decker, S. J., Dixon, J. E., & Saltiel, A. R. (1993). Sequence specificity in recognition of the epidermal growth factor receptor by protein tyrosine phosphatase-1B. Journal of Biological Chemistry, 268, 23634-23639. PubMed

Ohmichi, M., Decker, S. J., Pang, L., & Saltiel, A. R. (1992). Inhibition of the cellular actions of nerve growth factor by staurosporine and K252A results from the attenuation of the activity of the trk tyrosine kinase. Biochemistry, 31, 4034-4039. PubMed

Campbell, G. S., Pang, L., Miyasaka, T., Saltiel, A. R., & Cartersu, C. (1992). Stimulation by growth hormone of MAP kinase activity in 3T3-F442A fibroblasts. Journal of Biological Chemistry, 267, 6074-6080. PubMed

Ohmichi, M., Pang, L., Decker, S. J., & Saltiel, A. R. (1992). Nerve growth factor stimulates the activities of the Raf-1 and the mitogen-activated protein kinases via the Trk proto-oncogene. Journal of Biological Chemistry, 267, 14604-14610. PubMed

Misek, D. E., & Saltiel, A. R. (1992). An inositol phosphate glycan derived from a Trypanosoma brucei glycosyl phosphatidylinositol mimics some of the metabolic actions of insulin. Journal of Biological Chemistry, 267, 16266-16273.

Ohmichi, M., Decker, S. J., & Saltiel, A. R. (1992). Nerve growth factor stimulates the tyrosine phosphorylation of a 38-KDA protein that specifically associates with the Src homology domain of phospholipase-c-gamma-1. Journal of Biological Chemistry, 267, 21601-21606. PubMed

Saltiel, A. R., & Decker, S. J. (1992). Diversity in cellular signaling for nerve growth factor and insulin - Variations on a common theme. Journal of Investigative Dermatology, 98 (Suppl S), S17-S20. PubMed

Plourde, R., Dalarcao, M., & Saltiel, A. R. (1992). Synthesis and characterization of an insulin-mimetic disaccharide. Journal of Organic Chemistry, 57, 2606-2610.

Ohmichi, M., Decker, S. J., & Saltiel, A. R. (1992). Activation of phosphatidylinositol 3'-kinase by nerve growth factor involves indirect coupling of the Trk proto-oncogene with Src homology 2 domains. Neuron, 9, 769-777. PubMed

Zhu, G. C., Decker, S. J., & Saltiel, A. R. (1992). Direct analysis of the binding of Src homology 2 domains of phospholipase-C to the activated epidermal growth factor receptor. Proceedings of the National Academy of Sciences of the USA, 89, 9559-9563. PubMed

Zhu, G. C., Dudley, D. T., & Saltiel, A. R. (1991). Amylin increases cyclic-AMP formation in L6 myocytes through calcitonin gene-related peptide receptors. Biochemical and Biophysical Research Communications, 177, 771-776. PubMed

Ohmichi, M., Decker, S. J., Pang, L., & Saltiel, A. R. (1991). Nerve growth factor binds to the 140 kd trk proto-oncogene product and stimulates its association with the src homology domain of phospholipase-c-gamma-1. Biochemical and Biophysical Research Communications, 179, 217-223. PubMed

Darnell, J. C., Osterman, D. G., & Saltiel, A. R. (1991). Synthesis of phosphatidylinositol in rat liver microsomes is accompanied by the rapid formation of lysophosphatidylinositol. Biochimica et Biophysica Acta, 1084, 269-278. PubMed

Darnell, J. C., Osterman, D. G., & Saltiel, A. R. (1991). Fatty acid remodeling of phosphatidylinositol under conditions of de novo synthesis in rat liver microsomes. Biochimica et Biophysica Acta, 1084, 279-291.

Darnell, J. C., & Saltiel, A. R. (1991). Coenzyme A-dependent, ATP-independent acylation of 2-acyl lysophosphatidylinositol in rat liver microsomes. Biochimica et Biophysica Acta, 1084, 292-299. PubMed

Ohmichi, M., Decker, S. J., & Saltiel, A. R. (1991). Nerve growth factor induces the association of a 130 kd phosphoprotein with its receptor in PC-12 pheochromocytoma cells. Cell Regulation, 2, 691-697. PubMed

Ohmichi, M., Decker, S. J., Pang, L., & Saltiel, A. R. (1991). Phospholipase c-gamma-1 directly associates with the P70 Trk oncogene product through its Src homology domains. Journal of Biological Chemistry, 266, 14858-14861. PubMed

Hess, S. L., Suchin, C. R., & Saltiel, A. R. (1991). The specific protein phosphatase inhibitor okadaic acid differentially modulates insulin action. Journal of Cellular Biochemistry, 45, 374-380. PubMed

Shapiro, E., Brown, S. D., Saltiel, A. R., & Schwartz, J. H. (1991). Short-term action of insulin on Aplysia neurons - Generation of a possible novel modulator of ion channels. Journal of Neurobiology, 22, 55-62. PubMed

Fukui, Y., Saltiel, A. R., & Hanafusa, H. (1991). Phosphatidylinositol-3 kinase is activated in V-src, V-yes, and V-fps transformed chicken embryo fibroblasts. Oncogene, 6, 407-411. PubMed

Miyasaka, T., Sternberg, D. W., Miyasaka, J., Sherline, P., & Saltiel, A. R. (1991). Nerve growth factor stimulates protein tyrosine phosphorylation in PC-12 pheochromocytoma cells. Proceedings of the National Academy of Sciences of the USA, 88, 2653-2657. PubMed

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Articles (1980-1990)

Miyasaka, T., Miyasaka, J., & Saltiel, A. R. (1990). Okadaic acid stimulates the activity of microtubule associated protein kinase in PC-12 pheochromocytoma cells. Biochemical and Biophysical Research Communications, 168, 1237-1243. PubMed

Schwartz, J. H., Shapiro, E., Brown, S. D., & Saltiel, A. R. (1990). Short-term electrophysiological actions of insulin on Aplysia neurons - Identification of a possible novel modulatory second messenger mechanism. Cold Spring Harbor Symposia on Quantitative Biology, 55, 95-100. PubMed

Miyasaka, T., Chao, M. V., Sherline, P., & Saltiel, A. R. (1990). Nerve growth factor stimulates a protein kinase in PC-12 cells that phosphorylates microtubule-associated protein 2. Journal of Biological Chemistry, 265, 4730-4735. PubMed

Lisanti, M. P., Lebivic, A., Saltiel, A. R., & Rodriguez-Boulan, E. (1990). Preferred apical distribution of glycosyl-phosphatidylinositol (GPI) anchored proteins - A highly conserved feature of the polarized epithelial cell phenotype. Journal of Membrane Biology, 113, 155-167. PubMed

Pfeffer, L. M., Strulovici, B., & Saltiel, A. R. (1990). Interferon-alpha selectively activates the beta isoform of protein kinase C through phosphatidylcholine hydrolysis. Proceedings of the National Academy of Sciences of the USA, 87, 6537-6541. PubMed

Lisanti, M. P., Darnell, J. C., Chan, B. L., Rodriguez-Boulan, E., & Saltiel, A. R. (1989). The distribution of glycosyl-phosphatidylinositol anchored proteins is differentially regulated by serum and insulin. Biochemical and Biophysical Research Communications, 164, 824-832. PubMed

Chan, B. L., Chao, M. V., & Saltiel, A. R. (1989). Nerve growth factor stimulates the hydrolysis of glycosyl-phosphatidylinositol in PC-12 cells - A mechanism of protein kinase C regulation. Proceedings of the National Academy of Sciences of the USA, 86, 1756-1760. PubMed

Saltiel, A. R., Osterman, D. G., & Darnell, J. C. (1988). Role of glycosyl phosphoinositides in insulin action. Cold Spring Harbor Symposia on Quantitative Biology, 53, 955-963. PubMed

Saltiel, A. R., Osterman, D. G., Darnell, J. C., Sorbaracazan, L. R., Chan, B. L., Low, M. G., & Cuatrecasas, P. (1988). The function of glycosyl phosphoinositides in hormone action. Philosophical Transactions of the Royal Society of London Series B - Biological Sciences, 320, 345-358. PubMed

Lisanti, M. P., Sargiacomo, M., Graeve, L., Saltiel, A. R., & Rodriguez-Boulan, E. (1988). Polarized apical distribution of glycosyl-phosphatidylinositol anchored proteins in a renal epithelial cell line. Proceedings of the National Academy of Sciences of the USA, 85, 9557-9561. PubMed

Chan, B. L., Lisanti, M. P., Rodriguez-Boulan, E., & Saltiel, A. R. (1988). Insulin-stimulated release of lipoprotein lipase by metabolism of its phosphatidylinositol anchor. Science, 241, 1670-1672. PubMed

Saltiel, A. R., & Sorbaracazan, L. R. (1987). Inositol glycan mimics the action of insulin on glucose utilization in rat adipocytes. Biochemical and Biophysical Research Communications, 149, 1084-1092. PubMed

Saltiel, A. R., Fox, J. A., Sherline, P., Sahyoun, N., & Cuatrecasas, P. (1987). Purification of phosphatidylinositol kinase from bovine brain myelin. Biochemical Journal, 241, 759-763. PubMed

Saltiel, A. R. (1987). Insulin generates an enzyme modulator from hepatic plasma-membranes - Regulation of adenosine-3',5'-monophosphate phosphodiesterase, pyruvate-dehydrogenase, and adenylate-cyclase. Endocrinology, 120, 967-972. PubMed

Saltiel, A. R., Sherline, P., & Fox, J. A. (1987). Insulin-stimulated diacylglycerol production results from the hydrolysis of a novel phosphatidylinositol glycan. Journal of Biological Chemistry, 262, 1116-1121. PubMed

Fox, J. A., Soliz, N. M., & Saltiel, A. R. (1987). Purification of a phosphatidylinositol glycan-specific phospholipase C from liver plasma membranes - A possible target of insulin action. Proceedings of the National Academy of Sciences of the USA, 84, 2663-2667. PubMed Link

Saltiel, A. R., & Steigerwalt, R. W. (1986). Purification of putative insulin-sensitive cAMP phosphodiesterase or its catalytic domain from rat adipocytes. Diabetes, 35, 698-704. PubMed Link

Saltiel, A. R., & Cuatrecasas, P. (1986). Insulin stimulates the generation from hepatic plasma membranes of modulators derived from an inositol glycolipid. Proceedings of the National Academy of Sciences of the USA, 83, 5793-5797. PubMed Link

Saltiel, A. R., Fox, J. A., Sherline, P., & Cuatrecasas, P. (1986). Insulin-stimulated hydrolysis of a novel glycolipid generates modulators of cAMP phosphodiesterase. Science, 233, 967-972. PubMed Link

Saltiel, A. R., Doble, A., Jacobs, S., & Cuatrecasas, P. (1983). Putative mediators of insulin action regulate hepatic acetyl CoA carboxylase activity. Biochemical and Biophysical Research Communications, 110, 789-795. PubMed Link

Jacobs, S., Sahyoun, N. E., Saltiel, A. R., & Cuatrecasas, P. (1983). Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin-C. Proceedings of the National Academy of Sciences of the USA, 80, 6211-6213. PubMed Link

Saltiel, A. R., Thomas, C. G., & Nayfeh, S. N. (1982). Thyrotropin binding to porcine thyroid plasma membranes - Kinetic and thermodynamic analyses. Molecular and Cellular Endocrinology, 28, 299-312. PubMed Link

Saltiel, A. R., Siegel, M. I., Jacobs, S., & Cuatrecasas, P. (1982). Putative mediators of insulin action - Regulation of pyruvate dehydrogenase and adenylate cyclase activities. Proceedings of the National Academy of Sciences of the USA, 79, 3513-3517. PubMed Link

Saltiel, A., Jacobs, S., Siegel, M., & Cuatrecasas, P. (1981). Insulin stimulates the release from liver plasma membranes of a chemical modulator of pyruvate dehydrogenase. Biochemical and Biophysical Research Communications, 102, 1041-1047. PubMed Link

Saltiel, A. R., Powell-Jones, C. H. J., Thomas, C. G., & Nayfeh, S. N. (1981). Thyrotropin receptor adenylate cyclase function in human thyroid neoplasms. Cancer Research, 41, 2360-2365. PubMed Link

Saltiel, A. R., Powell-Jones, C. H. J., Thomas, C. G., & Nayfeh, S. N. (1981). Regulation of thyroid adenylate cyclase - Guanyl nucleotide modulation of thyrotropin receptor-adenylate cyclase function. Endocrinology, 109, 1578-1589. PubMed Link

Powell-Jones, C. H. J., Saltiel, A. R., Thomas, C. G., & Nayfeh, S. N. (1981). Dissociation kinetics of the thyrotropin receptor complex - Characterization of a slowly dissociable component. Molecular and Cellular Endocrinology, 24, 219-231. PubMed Link

Saltiel, A. R., Powell-Jones, C. H. J., Thomas, C. G., & Nayfeh, S. N. (1980). Apparent negative cooperativity kinetics in the absence of a non-linear scatchard plot of thyrotropin receptor interaction in a human thyroid adenoma. Biochemical and Biophysical Research Communications, 95, 395-403.

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Review Articles

Lazar, D.F., and Saltiel, A.R. (2006). Lipid Phosphatases as Drug Targets for Type 2 Diabetes Nat Rev Drug Discovery 5, 333-42

Chiang, S. H., Chang, L., & Saltiel, A. R. (2006). TC10 and insulin-stimulated glucose transport. Methods in Enzymology, 406, 701-714.

Chang, L., Chiang, S-H, and Saltiel, A.R. (2005). Insulin Signaling and the Regulation of Glucose Transport Mol Med 10, 65-71

Saltiel, A. R., & Pessin, J. E. (2003). Insulin signaling in microdomains of the plasma membrane. Traffic, 4, 711-716.

Baumann, C. A., & Saltiel, A. R. (2001). Spatial compartmentalization of signal transduction in insulin action. Bioessays, 23, 215-222.

Saltiel, A. R. (2001). New perspectives into the molecular pathogenesis and treatment of Type 2 diabetes. Cell, 104, 517-529.

Saltiel, A. R., & Kahn, C. R. (2001). Insulin signalling and the regulation of glucose and lipid metabolism. Nature, 414, 799-806.

Brady, M. J., & Saltiel, A. R. (2001). The role of protein phosphatase-1 in insulin action. Recent Progress in Hormone Research, 56, 157-173.

Olefsky, J. M., & Saltiel, A. R. (2000). PPAR gamma and the treatment of insulin resistance. Trends in Endocrinology and Metabolism, 11, 362-368.

Brady, M. J., Pessin, J. E., & Saltiel, A. R. (1999). Spatial compartmentalization in the regulation of glucose metabolism by insulin. Trends in Endocrinology and Metabolism, 10, 408-413.

Saltiel, A. R. (1996). Diverse signaling pathways in the cellular actions of insulin. American Journal of Physiology, 270, E375-E385.

Saltiel, A. R., & Sawyer, T. K. (1996). Targeting signal transduction in the discovery of antiproliferative drugs. Chemistry & Biology, 3, 887-893.

Saltiel, A. R., & Decker, S. J. (1994). Cellular mechanisms of signal trasduction for neurotrophins. Bioessays, 16, 405-411.

Saltiel, A. R. (1994). The paradoxical regulation of protein phosphorylation in insulin action. FASEB Journal, 8, 1034-1040.

Saltiel, A. R. (1991). The role of glycosyl-phosphoinositides in hormone action. Journal of Bioenergetics and Biomembranes, 23, 29-41.

Saltiel, A. R., & Decker, S. J. (1991). Diversity in cellular signaling for nerve growth factor and insulin - Variations on a common theme. Molecular and Cellular Endocrinology, 81, C197-C202.

Saltiel, A. R. (1990). Second messengers of insulin action. Diabetes Care, 13, 244-256.

Lisanti, M. P., Rodriguez-Boulan, E., & Saltiel, A. R. (1990). Emerging functional roles for the glycosyl-phosphatidylinositol membrane protein anchor. Journal of Membrane Biology, 117, 1-10.

Saltiel, A. R. (1990). Signal transduction in insulin action. Journal of Nutritional Biochemistry, 1, 180-188.

Saltiel, A. R. (1990). Second messengers of insulin action. Trends in Endocrinology and Metabolism, 1, 158-163.

Saltiel, A. R., Osterman, D. G., Darnell, J. C., Chan, B. L., & Sorbaracazan, L. R. (1989). The role of glycosylphosphoinositides in signal transduction. Recent Progress in Hormone Research, 45, 353-382.

Saltiel, A. R., & Cuatrecasas, P. (1988). In search of a second messenger for insulin. American Journal of Physiology, 255, C1-C11.

Low, M. G., & Saltiel, A. R. (1988). Structural and functional roles of glycosyl-phosphatidylinositol in membranes. Science, 239, 268-275.

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Editorial Material

Chen, X-W., Saltiel, A.R. (2006). TIRFing out Studies on Glut4 Trafficking. Dev Cell. 2007 Jan;12(1):4-5.

Lumeng, C. N., & Saltiel, A. R. (2006). Insulin signaling gives autophagy a push. Autophagy, 2, 250-253.

Cheng, A and Saltiel, A.R. (2006). More TORC for the Gluconeogenic Engine” Bioessays 28, 231

Saltiel, A. R. (2005). Holding the line on hepatic fat. Cell Metabolism, 2, 1-2.

Decker, S. J., & Saltiel, A. R. (2005). Staying in SHIP shape. Nature Medicine, 11, 123-124.

Saltiel, A. R. (2003). Muscle or fat? Rho bridges the GAP. Cell, 113, 144-145.

Saltiel, A. R. (2003). A TUG on glucose transport. Nature Medicine, 9, 1352.

Saltiel, A. R. (2003). Putting the brakes on insulin signaling. New England Journal of Medicine, 349, 2560-2562.

Saltiel, A. R., & Pessin, J. E. (2002). Insulin signaling pathways in time and space. Trends in Cell Biology, 12, 65-71.

Saltiel, A. R. (2001). You are what you secrete. Nature Medicine, 7, 887-888.

Saltiel, A. R. (2000). Another hormone-sensitive triglyceride lipase in fat cells? Proceedings of the National Academy of Sciences of the USA, 97, 535-537.

Brady, M. J., & Saltiel, A. R. (1999). Closing in on the cause of insulin resistance and type 2 diabetes. Journal of Clinical Investigation, 104, 675-676.

Saltiel, A. R. (1997). Hot Papers - Signal transduction - PD098059 is a specific inhibitor of mitogen-activated protein kinase kinase in vitro and in vivo by D. R. Alessi, A. Cuenda, P. Cohen, D. T. Dudley, A. R. Saltiel - Comments. Scientist, 11, 12.

Saltiel, A. R., Ravetch, J., & Aderem, A. A. (1991). Functional consequences of lipid-mediated protein membrane interactions. Biochemical Pharmacology, 42, 1-11.

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Notes

Pang, L., Sawada, T., Decker, S. J., & Saltiel, A. R. (1995). Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. Journal of Biological Chemistry, 270, 13585-13588.

Waters, S. B., Holt, K. H., Ross, S. E., Syu, L. J., Guan, K. L., Saltiel, A. R., Koretzky, G. A., & Pessin, J. E. (1995). Desensitization of Ras activation by a feedback disassociation of the SOS-GRB2 complex. Journal of Biological Chemistry, 270, 20883-20886.

Langlois, W. J., Sasaoka, T., Saltiel, A. R., & Olefsky, J. M. (1995). Negative feedback regulation and desensitization of insulin-stimulated and epidermal growth factor-stimulated P21(Ras) activation. Journal of Biological Chemistry, 270, 25320-25323.

Ohmichi, M., Decker, S. J., Pang, L., & Saltiel, A. R. (1991). Phospholipase c-gamma-1 directly associates with the P70 Trk oncogene product through its Src homology domains. Journal of Biological Chemistry, 266, 14858-14861.

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