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Curriculum Vitae

Personal Data

Alan Robert Saltiel
Director, Life Sciences Institute
John Jacob Abel Collegiate Professor in the Life Sciences
Professor of Internal Medicine and Physiology
Life Sciences Institute
210 Washtenaw Ave., 3rd Floor
Ann Arbor, MI 48109-2216
Tel: (734) 615-9787
Fax: (734) 763-6492
E-mail: saltiel@umich.edu
Website

Education

A.B. Zoology, Duke University , 1975
Ph.D. Biochemistry, University of North Carolina, 1980

Postdoctoral training

Postdoctoral Research Scientist, Mentor: Pedro Cuatrecasas,
Dept. of Molecular Biology, Wellcome Research Laboratories,
1981-1984

Academic Appointments

Assistant Professor, The Rockefeller University, 1984 -1990

Adjunct Assistant Professor, Dept. of Cell Biology, Cornell University School of Medicine, 1988 -1991

Adjunct Associate Professor, Dept. of Physiology, University of Michigan School of Medicine, 1990 -1994

Adjunct Professor, Dept. of Physiology, University of Michigan School of Medicine , 1994 -2001

Professor, Dept. of Internal Medicine and Molecular and Integrative Physiology, University of Michigan School of Medicine, 2001- present

John Jacob Abel Collegiate Professor in the Life Sciences, University of Michigan , 2002-present

Administrative Appointments

  • Senior Director, Dept. of Signal Transduction, Parke-Davis Pharmaceutical Research Division, Warner Lambert Co, 1990-1996
  • Senior Research Fellow, Dept. of Signal Transduction, Parke-Davis Pharmaceutical Research Division, Warner Lambert Co, 1992-1995
  • Distinguished Research Fellow, Dept. of Signal Transduction, Parke-Davis Pharmaceutical Research Division, Warner Lambert Co, 1995-2000
  • Senior Director, Dept. of Cell Biology, Parke-Davis Pharmaceutical Research Division, Warner Lambert Co, 1996-2000
  • Senior Research Scientist, Life Sciences Institute, University of Michigan, 2001-present
  • Associate Director, Life Sciences Institute, University of Michigan, 2002-2002
  • Director, Life Sciences Institute, University of Michigan, 2002-present

Consulting Positions (current)

  • Sankyo Pharma Research Institute
  • Kinase Advisory Board, Vertex Pharmaceuticals, Inc.
  • External Advisory Board, University of Pennsylvania Diabetes Center
  • Scientific Advisory Board, Quatrx Pharmaceuticals
  • Scientific Advisory Board, Invitrogen
  • Scientific Advisory Board, Phenomix

Scientific Activities

  • New York State Health Research Council, Diabetes Research Section, 1985-1988
  • Juvenile Diabetes Foundation International, Medical Science Review Committee, 1988-1991
  • American Diabetes Association, Committee on Research, 1990-1993
  • Journal of Cellular Biochemistry, Associate Editor, 1989-present
  • National Institutes of Health, Physiological Chemistry Study Section, 1993-1997
  • American Society of Pharmacology and Experimental Therapeutics, Executive Committee of the Molecular Pharmacology Division, 1994-1998
  • American Journal of Physiology, Editorial Board, 1995-2001
  • Journal of Clinical Investigation, Associate Editor, 1997-2002
  • Diabetes, Editorial Board, 1997-1999
  • Endocrinology, Editorial Board, 1997-2001
  • Journal of Biological Chemistry, Editorial Board, 1997-2002
  • Current Opinion in Oncologic, Endocrine and Metabolic Drugs, Editorial Board, 1998-present
  • Molecular Endocrinology, Editorial Board, 2000-2001
  • Journal of Clinical Investigation, Board of Consulting Editors, 2002-present
  • Molecular Medicine, Deputy Editor, 2002-present
  • Cell Metabolism, Editorial Board, 2004-present

Grant Support (current)

RO1 DK60591 "Signaling Pathways in Insulin Action"
PI: Alan R. Saltiel
02/01/02-01/31/07
Total direct costs: $1,250,000

RO1 DK60597 "Hormonal regulation of Glycogen Synthesis"
PI: Alan R. Saltiel
02/01/02-01/31/07
Total direct costs: $1,250,000

RO1 DK61618 "The Role of G Proteins in Insulin Action"
PI: Alan R. Saltiel
4/1/02-3/31/07
Total direct costs: $1,250,000.

Mentor Based Postdoctoral Fellowship, American Diabetes Association
PI: Alan R. Saltiel
7/1/02-6/30/05
Total direct costs: $105,000.

Honors and Awards

  • Graduation with Magna Cum Laude Distinction, Duke University, 1975
  • Atlantic Coast Conference Academic Honor Award, 1975
  • American Diabetes Association Rosalyn S. Yalow Research and Development Award, 1984
  • Irma T. Hirschl Scholar, 1986
  • Established Investigator, American Heart Association, 1989
  • John Jacob Abel Award, American Society of Pharmacology and Experimental Therapeutics, 1990
  • American Society of Clinical Investigation (Honorary), 2001
  • Kroc Lecturer, University of Pennsylvania, 2004
  • Santiago Lecturer, Washington University St. Louis, 2005
  • Election to the Institute of Medicine, National Academies of Sciences, 2005
  • Distinguished Scientist in Basic Research, Clinical Ligand Assay Society, 2006

Memberships and Offices in Professional Societies

  • American Association for the Advancement of Science, 1977
  • New York Academy of Sciences, 1980
  • American Diabetes Association, 1981
  • The Endocrine Society, 1981
  • The Harvey Society, 1984
  • Society of the Sigma Xi, 1987
  • American Society of Biochemistry and Molecular Biology, 1988
  • American Society of Pharmacology and Experimental Therapeutics, 1988
  • The Biochemical Society, 1995
  • North American Society for the Study of Obesity, 1996
  • American Society of Clinical Investigation, 2001
  • Pluto Society, American Association of Pathologists, 2003
  • Institute of Medicine of the National Academies of Sciences, 2005

Extramural Invited Presentations (major)

  1. Pathogenesis of NIDDM, Brooklodge Symposium, Kalamazoo , Michigan , January, 1987.
  2. Calcium Days Symposium, NIH, March, 1987.
  3. Cold Spring Harbor Symposium on Inositol Lipids, May, 1987.
  4. Arden House Symposium, Cellular Proliferation and Growth, May, 1987.
  5. American Diabetes Association, Plenary Symposium on Insulin Action, June, 1987.
  6. Endocrine Society, Plenary Symposium on Inositol Lipids, June, 1987.
  7. Oslo Symposium on Mechanisms of Insulin Action, July, 1987.
  8. Gordon Conference, Membrane Transport Phenomenon, July, 1987.
  9. Gordon Conference, Hormone Action, August, 1987.
  10. New York Academy of Science, Symposium on Phospholipases, October, 1987.
  11. Mount St. Odile, Symposium on Molecular Biology of Hormone Action, October, 1987.
  12. University Lecture Series, Southwestern Medical School , Dallas , November, 1987.
  13. Royal Society of London , Inositol Lipids, London , December 1987.
  14. New England Symposium on Insulin Action, Keynote Speaker, February, 1988
  15. Juvenile Diabetes Foundation, Inositol Lipids in Complications of Diabetes, San Diego , February, 1988.
  16. Juvenile Diabetes Foundation International; Monte Carlo , March, 1988.
  17. UC-Riverside Symposium on Molecular Endocrinology, March, 1988.
  18. UCLA-Keystone, Phospholipases, April, 1988.
  19. NIH Symposium on Molecular Genetics of Diabetes Mellitus, April 1988
  20. Cold Spring Harbor Symposium on Molecular Biology of Signal Transduction, May, 1988.
  21. Endocrinology under 35, Florence , Italy (meeting organizer) May, 1988.
  22. Gordon Conference, Peptide Growth Factors, August, 1988.
  23. Laurentian Hormone Conference, Quebec , August, 1988.
  24. Joslin Diabetes Center Symposium, Boston , MA , Oct, 1988
  25. IXth International Washington Spring Symposium, "Biology of Cellular Transducing Signals". May, 1989
  26. Gordon Conference, Lipid Metabolism, June, 1989
  27. Marquette Life Sciences Symposium, Milwaukee , WI , March, 1990
  28. American Society of Biochemistry and Molecular Biology, Symposium on Signal Transduction, June, 1990
  29. Chicago Signal Transduction Symposium, May, 1991
  30. Phospholipids and Signal Transmission, Weisbaden , Germany , May, 1991
  31. Biology of the Skin, Aspen , CO , May, 1991
  32. Mechanisms of Insulin Action, Airlie House, Airlie , Va. , June, 1991
  33. Gordon Conference, Medicinal Chemistry, Aug, 1991
  34. Weizmann-Rockefeller Symposium on Neuronal Plasticity, Rehovot , Israel , Oct, 1991
  35. Juan March Foundation, Workshop on Glycosyl-Phosphatidylinositol in Cellular Signaling, Madrid , Spain , Oct, 1991
  36. Distinguished Scientist Lecture, SUNY Buffalo , Nov, 1992.
  37. Parke-Davis Scientists Lecture Series, Jan, 1993
  38. V International Symposium on Insulin Receptors and Insulin Action, Munich , Germany , May, 1993
  39. American Society for Cell Biology, Plenary Symposium on Protein Kinases, Dec, 1993.
  40. Miami Winter Biotechnology Symposium, Plenary Session on Molecular Biology of Human Disease, Feb, 1994
  41. Molecular Biology Symposium, Plastic Surgery Research Council, Ann Arbor, MI, June, 1994
  42. Signal Transduction Therapy, San Francisco , CA , (meeting organizer) August, 1994
  43. IIGB Seventh Annual Workshop on Signal Transduction, Capri , Italy , Oct, 1994
  44. Nara Conference on Insulin Action and its Disorders, Nara , Japan , Nov, 1994
  45. Determinants of Specificity in Growth Factor Signaling, ASMBC Fall Symposium, Lake Tahoe, CA, (meeting organizer), Oct, 1995
  46. IX Conference on Second Messengers and Protein Phosphorylation, Nashville , Tenn , Oct, 1995
  47. Miami Winter Biotechnology Meeting, Plenary Session on Therapeutic Management of Disease, Feb, 1996
  48. American Diabetes Association, Symposium on Inhibitors of Insulin Action, San Francisco , CA , June, 1996
  49. National Medicinal Chemistry Symposium, Ann Arbor , MI , June, 1996
  50. Specificity in Growth Factor Receptor Signaling, ASMBC Fall Symposium, Lake Tahoe, CA (meeting organizer), Oct, 1996
  51. Keystone Meeting on Insulin Action and Secretion in NIDDM, Park City , Jan, 1997
  52. Keystone Meeting on Temporal and Spatial Determinants of Specificity in Signal Transduction, Keystone, April, 1997 (meeting organizer)
  53. American Association of Cancer Research, Symposium on Signal Transduction, April, 1997
  54. Endocrine Research Society, New Therapies for NIDDM, Vancouver , Canada , May, 1997
  55. Gordon Research Conference, Hormone Action, July, 1997
  56. Aspen Lipid Conference, Aug, 97
  57. Experimental Biology '98, San Francisco , CA , April, 1998
  58. VII International Symposium on Insulin Receptors and Insulin Action, Jerusalem , Israel , May, 1998
  59. American Diabetes Association Annual Meeting, Symposium on "Downstream Targets of Insulin Action", Chicago , June, 1998
  60. Miami Winter Biotechnology Meeting, Miami , FL , Feb, 1999
  61. Keystone Symposium on PPARs, Keystone, CO, May, 1999
  62. ASBMB Meeting, Plenary Session on Signal Transduction, San Francisco , May, 1999
  63. Advances in Metabolic Regulation, SUNY Stony Brook, May, 1999
  64. Steenbock Symposium: "Adipocyte Biology and Hormone Signaling", Madison , WI , June, 1999
  65. American Diabetes Association Annual Meeting, Symposium on "PPARS in Health and Disease", San Diego , June, 1999
  66. FASEB Summer Conference on Protein Kinases, Snowmass , CO , July, 1999
  67. North American Association for the Study of Obesity, Symposium on Signal Transduction, Charleston , SC , Nov, 1999
  68. Keystone Symposium on "Diabetes Mellitus: Molecular Mechanisms, Genetics and Prospects for New Therapy", Taos , NM , Feb, 2000 (meeting organizer)
  69. NIH-NCRR Symposium: "The Liver in Systemic Disorders of Fat and Glucose Metabolism", Dallas , TX , May, 2000
  70. Endocrine Society, Symposium on Protein Phosphatases, Toronto , June, 2000
  71. Japanese Diabetes Society 3 rd Symposium on Insulin Action. Awaji Island , Japan , Sept, 2000
  72. Frontiers in Diabetes Research, Columbia University , Nov, 2000
  73. First International Workshop on Insulin Resistance, Amelia Island , FL, Feb, 2001
  74. Symposium on the Molecular and Physiological Aspects of Type 2 Diabetes and Obesity, Karolinska Institute, Stockholm , April, 2001
  75. European Commission Symposium on Regulation of Glucose Transport, Monastery Rolduc, Kerkrade , The Netherlands , May, 2001
  76. Gordon Research Conference, Second Messengers and Protein Phosphorylation, Kimball Union Academy , June, 2001
  77. FASEB Summer Conference, Glucose Transporters, Snowmass , CO , June, 2001
  78. Van der Kloot Symposium on Cell Signaling: Metabolism and Disease, SUNY Stony Brook, Oct, 2001.
  79. World Congress of Nephrology, Plenary Symposium on New Advances in Diabetes, San Francisco , Oct, 2001.
  80. Molecular Millennium. The Levine Beckman Symposium, City of Hope , Duarte , CA , Nov, 2001.
  81. Keystone Symposium on "Diabetes Mellitus: Molecular Mechanisms, Genetics and Prospects for New Therapy", Keystone, CO, Jan, 2002 (meeting organizer)
  82. Ernst Klenk Foundation Conference, "Glucose and Insulin signaling pathways: Implications for metabolic disorders" Cologne , Germany , Feb, 2002.
  83. Rank Prize Symposium on Insulin, Grasmere , England , May, 2002.
  84. Tyrosine Phosphorylation and Cell Signaling, Salk Institute, La Jolla , CA , August, 2002.
  85. Western Pharmacology Society, Lake Tahoe , Nevada , Feb, 2003
  86. American Diabetes Association, Plenary Session on Glucose Transport, New Orleans , LA , June, 2003
  87. FASEB Meeting on Glucose transport, Snowmass , CO , Aug, 2003
  88. International Diabetes Federation, Plenary session, Paris , FR, Aug, 2003
  89. Plenary Lecture of the Australian Diabetes Society/Australian Society for the Study of Endocrinology, Melbourne , Australia , Sept, 2003
  90. Kroc Lecture, University of Pennsylvania Diabetes Center, March, 2004
  91. Plenary Lecture on Insulin Signaling, Endocrine Society, New Orleans, LA, June, 2004
  92. Plenary Lecture, Insulin Receptor 04, Nice, France, October, 2004
  93. Plenary Lecture, Keystone meeting on Diabetes, Keystone, CO, Jan, 2005.
  94. Julio Santiago Memorial Lecture, Washington University School of Medicine, St. Louis., MO, March, 2005.
  95. FASEB Conference on Glucose Transport, Snowmass, CO, Aug, 2005
  96. Key Symposium, Swedish Academy of Sciences, Stockholm, Sweden, May, 2006
  97. Plenary Lecture, Chicago Diabetes Day, University of Chicago, June, 2006

Committee and Administrative Service (current)

Michigan Diabetes Research and Training Center
Executive Committee
MDRTC Director Search Committee
Michigan Comprehensive Cancer Center
Academic Program Group
Health Sciences Council
Advisory Board, Life Sciences, Values and Society Program
Advisory Committee, University of Michigan Depression Center
Executive Committee, Institute for Social Research
Executive Advisory Committee, Michigan Metabolomics and Obesity Center

Patents

Saltiel, A.R. U.S. patent #4839466 "Insulin activity messengers" June 13, 1989

Saltiel, A.R. U.S. patent #4906468 "Insulin activity messengers, their precursors and uses thereof" March 6, 1990

Saltiel, A.R. and Bridges, A. U.S. patent #5525625 "2-(2-Amino-3-Methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders." June 11, 1996

Bisgaier, C., Creger, P., Tafuri, S. and Saltiel, A.R. U.S. patent #5648387 "Carboxyalkylethers, Formulations, and Treatment of Vascular Diseases" July 15, 1997

Saltiel, A.R., Fry, D., Hamby, J.M. and Decker, S.J. U.S. patent #5721266 "Substituted Imidazolinyl-Imidazolines as Antagonists of SH2 Binding and Therapeutic Uses Thereof" Feb 24, 1998

Bisgaier, C.L., Creger, P.L., Saltiel, A.R. and Tafuri, S.R. US Patent #5750569 “Carboxyalkylethers, formulations, and treatment of vascular diseases” May 12, 1998

Bisgaier, C.L., Creger, P.L., Saltiel, A.R. and Tafuri, S.R. US Patent #5756544 “Carboxyalkylethers, formulations, and treatment of vascular diseases” May 26, 1998

Bisgaier, C.L., Creger, P.L., Saltiel, A.R. and Tafuri, S.R. US Patent #5783600 “Carboxyalkylethers, formulations, and treatment of vascular diseases” July 21, 1998

Lunney, E., Para , K., Plummer, M., Prasad, J., Saltiel, A.R., Sawyer, T., Shahripour, Singh, J., Stankovic. C. U.S. patent #5922697 "Compounds, compositions and methods for inhibiting the binding of proteins containing an SH2 domain to cognate phosphorylated proteins." July 13, 1999.

Brady. M.J. Printen, J. and Saltiel, A.R., U.S. patent #6232057 "Protein Targeting to Glycogen", June 6, 2001

Barrett , S.D. , Bridges, A. Cody, D.R., Doherty, A.M., Dudley, D.T., Saltiel, A.R., Schroeder, M.C. and Tecle, H. U.S. patent #6251943 "Method of treating or preventing septic shock by administering a MEK inhibitor", June 26, 2001

Saltiel, A.R.. and Bridges, A. U.S. patent #6310060 "2-(4-Bromo or Iodo Phenylamino) Benzoic acid derivatives and their use as MEK inhibitors", Oct 30, 2001

Bridges, A. and Saltiel, A.R.. US Patent # 6492363 "2-(4-Bromo or 4-Iodo Phenylamino) Benzoic Acid Derivatives, Dec 10, 2002

Bridges, A.J. Dudley, D.T., Mobley; J.L., and Saltiel, A.R.. US Patent #6,696,440 “Treatment of asthma with MEK inhibitors” Feb 24, 2004

Barrett, S.D., Bridges, A.J., Doherty, A.M.; Dudley; D.T., Saltiel, A.R., and Tecle; H. US Patent #6,821,963 “4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors” Nov 24, 2004

Barrett, S.D., Bridges, A.J., Cody, D.R., Doherty, A.M., Dudley, D.T., Saltiel, A.R., Schroeder, M.C., Tecle, H. US Patent #7,019,033 “2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives” March 28, 2006

Trainees

  1. Ronald W. Steigerwalt, Ph.D., UCSF, 1983.
    Postdoctoral fellow, 1983-84.
  2. Lynn Sorbara, Ph.D., Albert Einstein School of Medicine, 1986.
    Postdoctoral fellow, 1986-1989.
  3. David Osterman, Ph.D., University of Chicago , 1985.
    Postdoctoral fellow, 1986-1989.
  4. Jennifer Cordes Darnell, Ph.D., Rockefeller University , 1990.
    Graduate fellow, 1987-1990.
  5. Betty Chan, M.D., University of Toronto , 1984.
    Postdoctoral fellow, 1987-1988.
  6. Susan Hess, Ph.D., City University of New York , 1988.
    Postdoctoral Fellow, 1988-1990.
  7. Tadayo Miyasaka, Ph.D., Tokyo University , 1987.
    Research Associate, 1989-1991.
  8. David Misek, Ph.D., State University of New York , 1986.
    Postdoctoral fellow, 1989-1993.
  9. Guochang Zhu, M.D., Second Medical College , Shanghai , 1984.
    Postdoctoral fellow, 1989-1991, Senior Research Associate, 1991-1994.
  10. Long Pang, Ph.D., New York University , 1990.
    Postdoctoral fellow, 1990-1994.
  11. Masahide Ohmichi, M.D., Ph.D., Osaka Univ. School of Medicine, 1990.
    Postdoctoral fellow, 1990-1993.
  12. Kim Milarski, Ph.D., Northwestern University, 1989.
    Postdoctoral fellow, 1991-1994.
  13. Vered Ribon, Ph.D., Weizmann Institute of Science, 1992.
    Postdoctoral fellow, 1992-1999.
  14. Dan Lazar, Ph.D., University of Michigan , 1992.
    Postdoctoral fellow, 1992-1997.
  15. Cynthia Mastick, Ph.D., Carnegie Mellon University , 1990.
    Postdoctoral fellow, 1993-1995.
  16. Takeshi Sawada, M.D., Ph.D., Osaka Univ. School of Medicine, 1993
    Postdoctoral fellow, 1993-1995
  17. Li-Jhun Syu, Ph.D., Michigan State University , 1994.
    Postdoctoral fellow, 1994-1999.
  18. Yoichi Noda, Ph.D., University of Tokyo , 1994.
    Postdoctoral fellow, 1994-1996.
  19. Matthew Brady, Ph.D., University of Chicago , 1994.
    Postdoctoral fellow, 1994-1998.
  20. Russell Weise, Ph.D., University of Wisconsin , 1992.
    Postdoctoral fellow, 1994-1995.
  21. John Printen, Ph.D., University of Oregon , 1995.
    Postdoctoral fellow, 1995-1998.
  22. Man Chang, Ph.D., Wayne State University , 1995.
    Postdoctoral fellow, 1996-1999.
  23. Christian Baumann, Ph.D., George Washington University , 1997.
    Postdoctoral fellow, 1997-2000.
  24. Jing Min, Ph.D., University of Chicago , 1997.
    Postdoctoral fellow, 1997-1999.
  25. Noel Fong, Ph.D., University of California , Davis , 1998.
    Postdoctoral fellow, 1998-2000.
  26. Barry Press, Ph.D., Northwestern University, 1998.
    Postdoctoral fellow, 1998-1999.
  27. Shian-Huey Chiang, Ph.D., University of Michigan , 2001
    Graduate fellow, 1998-2001; postdoctoral fellow, 2001-2002.
  28. Jeffrey Skinner, Ph.D., Purdue University , 1998
    Postdoctoral fellow, 1998-2002.
  29. Akiko Kimura, M.D., Ph.D., Osaka University School of Medicine, 1999
    Postdoctoral fellow, 1999-2002.
  30. Sean Crosson, Ph.D., University of Saskatchewan , 1999
    Postdoctoral fellow, 2000-present.
  31. Joseph Hwang, Ph.D., University of Florida , 2000
    Postdoctoral fellow, 2000- present.
  32. Louise Chang, Ph.D., Boston University , 2000
    Postdoctoral fellow, 2000-present.
  33. Mayumi Inoue, M.D., Ph.D., Kyoto University , 2000
    Postdoctoral fellow, 2000-present.
  34. Jun Liu, Ph.D., University of Virginia , 2000
    Postdoctoral fellow, 2001-present.
  35. Yoko Okamoto, M.D., Ph.D., Osaka University , 2000
    Postdoctoral fellow, 2001-present.
  36. Marie Legendre, University of Paris
    Visiting Graduate Fellow, 2001-2002.
  37. Mei Zhang, M.D., Ph.D., University of Cincinnati , 2001
    Postdoctoral fellow, 2002-present.
  38. Irfan Lodhi, University of Michigan
    Graduate Fellow, 2002-present
  39. Alan Cheng, Ph.D., McGill University , 2003
    Postdoctoral fellow, 2003-present
  40. Xiaowei Chen, University of Michigan
    Graduate fellow, 2003-present
  41. Carey Lumeng, M.D., Ph.D., University of Michigan, 2000
    Fellow in Pediatric Pulmonology, 2004-present
  42. Xiaoming Zhou, M.D., Ph.D., Nanjin University, 1999
    Postdoctoral fellow, 2004-2005
  43. Merlijn Bauzine, Ph.D., University of Leiden, 2004
    Postdoctoral fellow, 2004-present
  44. David Bridges, Ph.D., University of Calgary, 2005
    Postdoctoral fellow, 2005-present
  45. Dara Leto, University of Michigan
    Graduate Fellow, 2006-present

Bibliography(abstracts not included): Peer-Reviewed Publications

Original articles

  1. Saltiel, A.R. , Powell-Jones, C.H. J., Thomas, C.G., Jr. and Nayfeh, S.H. "Apparent Negative Cooperativity Kinetics in the Absence of a Nonlinear Scatchard Plot of Thyrotropin Receptor Interaction in a Human Thyroid Adenoma." (1980) Biochem. Biophys. Res. Commun. 95 , 395.
  2. Saltiel, A.R. , Powell-Jones, C.H.J., Thomas, C.G., Jr. and Nayfeh, S.N. "Thyrotropin Receptor-Adenylate Cyclase Function In Human Thyroid Neoplasms." (1981) Cancer Res. 41 , 2360.
  3. Saltiel, A.R. , Powell-Jones. C. H. J., Thomas, C. G., Jr. and Nayfeh, S. N. "Regulation of Thyroid Adenylate Cyclase: Guanyl Nucleotide Modulation of Thyrotropin Receptor Adenylate Cyclase Function." (1981) Endocrinology 109 , 1978.
  4. Powell-Jones, C. H. J., Saltiel, A. R. , Thomas, C. G., Jr. and Nayfeh, S. N. "Dissociation Kinetics of the Thyrotropin Receptor Complex; Characterization of a Slowly Dissociable Component." (1981) Mol. Cell. Endo. 24 , 219.
  5. Saltiel, A. R. , Jacobs, S., Siegel, M. I. and Cuatrecasas, P. "Insulin Stimulates the Release from Liver Plasma Membranes of a Chemical Modulator of Pyruvate Dehydrogenase." (1981) Biochem. Biophys. Res. Commun. 102 , 1041.
  6. Saltiel, A. R. , Thomas, C. G., Jr. and Nayfeh, S. N. "Thyrotropin Binding to Porcine Thyroid Plasma Membranes: Kinetic and Thermodynamic Analyses." (1981) Mol. Cell. Endo. 28 , 299.
  7. Saltiel, A. R. , Siegel, M. I., Jacobs, S. and Cuatrecasas, P. "Putative Mediators of Insulin Action: Regulation of Pyruvate Dehydrogenase and Adenylate Cyclase Activities." (1982) Proc. Natl. Acad. Sci. USA 79, 3513.
  8. Saltiel, A.R. , Doble, A., Jacobs, S. and Cuatrecasas, P. "Putative Mediators of Insulin Action Regulate Hepatic Acetyl CoA Carboxylase Activity." (1983) Biochem. Biophys. Res. Commun. 110 , 789.
  9. Jacobs, S., Sahyoun, N.E., Saltiel, A. R. and Cuatrecasas, P. "Phorbol Esters Stimulate the Phosphorylation of Receptors for Insulin and Somatomedin C." (1983) Proc. Natl. Acad. Sci. USA 80 , 6211.
  10. Saltiel, A. R. and Steigerwalt, R. W. "Purification of a Putative Insulin Sensitive cAMP Phosphodiesterase or its Catalytic Domain from Rat Adipocytes." (1986) Diabetes 35 , 698.
  11. Saltiel, A.R. and Cuatrecasas, P. "Insulin Stimulates the Generation from Hepatic Plasma Membranes of Modulators Derived from an Inositol Glycolipid." (1986) Proc. Natl. Acad. Sci. USA 87 , 5793.
  12. Saltiel, A. R. , Fox, J. A., Sherline, P. and Cuatrecasas, P. "Insulin Stimulated Hydrolysis of a Novel Glycolipid Generates Modulators of cAMP Phosphodiesterase." (1986) Science 233 , 967.
  13. Saltiel, A.R. , Fox, J. A., Sherline, P., Sahyoun N.E. and Cuatrecasas, P. "Purification of Phosphatidylinositol Kinase from Rat Brain Myelin." (1987) Biochem J. 241 , 759.
  14. Saltiel, A.R. , Sherline, P. and Fox, J. A. "Insulin Stimulated Diacylglycerol Production Results from the Hydrolysis of a Novel Phosphatidylinositol-Glycan." (1987) J. Biol. Chem. 262 , 1116.
  15. Saltiel, A.R. "Insulin Generates an Enzyme Modulator from Hepatic Plasma Membranes: Regulation of cAMP Phosphodiesterase, Pyruvate Dehydrogenase and Adenylate Cyclase." (1987) Endocrinology. 120 , 967.
  16. Fox, J.A., Soliz , N.M. and Saltiel, A.R. "Purification of a Phosphatidylinositol-Glycan Specific Phospholipase C from Liver Plasma Membranes: a Possible Target of Insulin Action." (1987) Proc. Nat. Acad. Sci. USA 84 , 2663.
  17. Saltiel, A. R. and Sorbara-Cazan, L. "Inositol-Glycan Mimicks the Action of Insulin on Glucose Utilization in Intact Adipocytes." (1987) Biochem. Biophys. Res. Commun. 149 , 1084.
  18. Chan, B.L., Lisanti, M.P., Rodriguez-Boulan, E. and Saltiel, A.R. "Insulin-stimulated Release of Lipoprotein Lipase by Metabolism of its Phosphatidylinositol Anchor." (1988) Science 241 , 1670.
  19. Lisanti, M.P., Sargiacomo, M., Graeve, L., Saltiel, A.R. and Rodriguez-Boulan, E. "Polarized Apical Distribution of Glycosyl-Phosphatidylinositol Anchored Proteins in a Renal Epithelial Cell Line." (1988) Proc. Natl. Acad. Sci. USA 85 , 9557.
  20. Chan, B.L., Chao, M.V. and Saltiel, A.R. "Nerve Growth Factor Stimulates the Hydrolysis of Glycosyl-Phosphatidylinositol in PC-12 Cells: A Novel Mechanism of Protein Kinase C Regulation." (1989) Proc. Natl. Acad. Sci. USA 86 , 1756.
  21. Lisanti, M.P., Darnell, J.C., Chan, B.L., Rodriguez-Boulan, E. and Saltiel, A.R. "The Distribution of Glycosyl-Phosphatidylinositol Anchored Proteins is Differentially Regulated by Serum and Insulin." (1989) Biochem. Biophys. Res. Commun. 164 , 824.
  22. Lisanti, M.P., Le Bivic, A., Saltiel, A.R. and Rodriguez-Boulan, E. "Apical Localization of Glycosyl-Phosphatidylinositol Anchored Proteins: A Highly Conserved Feature of the Polarized Epithelial Cell Phenotype." (1990) J. Mem. Biol. 113 , 155.
  23. Lisanti, M.P., Rodriguez-Boulan, E. and Saltiel, A.R. "Emerging Functional Roles for the Glycosyl-Phosphatidylinositol Membrane Protein Anchor." (1990) J. Mem. Biol. 117 , 1.
  24. Miyasaka, T., Chao, M.V., Sherline, P. and Saltiel, A.R. "Nerve Growth Factor Stimulates the Activity of a Microtubule Associated Protein Kinase in PC-12 Cells." (1990) J. Biol. Chem. 265 , 4730.
  25. Miyasaka, T., Miyasaka, J. and Saltiel, A.R. "Okadaic Acid Stimulates the Activity of a Microtubule Associated Protein Kinase in PC-12 Pheochromocytoma Cells." (1990) Biochem. Biophys. Res. Commun. 168 , 1237.
  26. Darnell, J.C., Osterman, D.G. and Saltiel, A.R. "Phosphatidylinositol Synthesis is Accompanied by the Rapid Accumulation of Lysophosphatidylinositol." (1991) Biochim. Biophys. Acta 1084 , 269.
  27. Darnell, J.C., Osterman, D.G. and Saltiel, A.R. "Fatty Acid Remodeling of Phosphatidylinositol under Conditions of De Novo Synthesis in Rat Liver Microsomes." (1991) Biochim. Biophys. Acta 1084 , 279.
  28. Darnell, J.C. and Saltiel, A.R. "CoA-Dependent, ATP-Independent Acylation of 2-Acyl Lyso-Phosphatidylinositol in Rat Liver Microsomes." (1991) Biochim. Biophys. Acta 1084 , 292.
  29. Hess, S., Suchin, C. and Saltiel, A.R. "The Protein Phosphatase Inhibitor Okadaic Acid Differentially Modulates Insulin Action." (1991) J. Cell. Biochem. 45 , 374.
  30. Pfeffer, L.M., Strulovici, B. and Saltiel, A.R. "Interferon a Selectively Activates the b Isoform of Protein Kinase C Through Phosphatidylcholine Hydrolysis." (1990) Proc. Natl. Acad. Sci. USA 87 , 6537.
  31. Shapiro, E., Brown, S., Saltiel, A.R. and Schwartz, J.H. "Short-term Actions of Insulin on Aplysia Neurons: Generation of a Possible Novel Modulator of Ion Channels." (1991) J. Neurobiol. 22 , 55.
  32. Saltiel, A.R. , Ravetch, J. and Aderem, A.A. "Functional Consequences of Lipid-mediated Protein-Membrane Interactions." (1991) Biochem. Pharmacol. 42 , 1.
  33. Schwartz, J.H., Shapiro, E., Brown, S.D. and Saltiel, A.R. "Short-term Electrophysiological Actions of Insulin on Aplysia Neurons: Identification of a Possible Novel Modulatory Second Messenger Mechanism." (1990) Cold Spring Harbor Symp. Quant. Biol. 55, 95.
  34. Fukui , Y., Saltiel, A.R. and Hanafusa, H. "Phosphatidylinositol-3 Kinase is Activated in v -src , v- yes and v- fps Transformed Chicken Embryo Fibroblasts." (1991) Oncogene 6 , 407.
  35. Miyasaka, T., Sternberg, D.W., Miyasaka, J., Sherline, P. and Saltiel, A.R. "Nerve Growth Factor Stimulates Protein Tyrosine Phosphorylation in PC12 Pheochromocytoma Cells." (1991) Proc. Natl. Acad. Sci. USA 88 , 2653.
  36. Zhu, G., Dudley, D.T. and Saltiel, A.R . "Amylin Increases Cyclic AMP Formation in L6 Myocytes Through Calcitonin Gene-Related Peptide Receptors." (1991) Biochem. Biophys. Res. Commun. 177 , 771.
  37. Ohmichi, M., Decker, S.J. and Saltiel, A.R. "Nerve Growth Factor Induces the Association of a 130Kd Phosphoprotein with its Receptor in PC-12 Pheochromocytoma Cells." (1991) Cell Regulation (now Mol. Biol. Cell) 2 , 691.
  38. Ohmichi, M., Decker, S.J., Pang, L. and Saltiel, A.R. "Phospholipase C- g Directly Associates with the p70 trk Oncogene Product through its src Homology Domains." (1991) J. Biol. Chem. 266 , 14858.
  39. Ohmichi, M., Decker, S.J., Pang, L. and Saltiel, A.R. "Nerve Growth Factor Binds to the 140kd trk Protooncogene Product and Stimulates its Association with the src Homology Domain of Phospholipase C- g ." (1991) Biochem. Biophys. Res. Commun. 179 , 217.
  40. Ohmichi, M., Decker, S.J., Pang, L. and Saltiel, A.R. "Inhibition of the Cellular Actions of Nerve Growth Factor by Staurosporine and K252A Result from the Attenuation the Activity of the Trk Tyrosine Kinase." (1992) Biochemistry 31 , 4034.
  41. Campbell , G.S., Pang, L., Miyasaka, T., Saltiel, A.R. and Carter-Su, C. "Stimulation by Growth Hormone of MAP Kinase Activity in 3T3-F442A Fibroblasts." (1992) J. Biol. Chem. 267 , 6074.
  42. Plourde, R., d'Alarcao, M. and Saltiel, A.R. "Synthesis and Characterization of an Insulin-Mimetic Disaccharide." (1992) J. Org. Chem. 57 , 2606.
  43. Misek, D.M. and Saltiel, A.R. "An Inositol Phosphate Glycan Derived from a Trypanosoma Brucei Glycosyl-Phosphatidylinositol Mimics Some of the Metabolic Actions of Insulin." (1992) J. Biol. Chem. 267 , 16266.
  44. Ohmichi, M., Pang, L., Decker, S.J. and Saltiel, A.R. "Nerve Growth Factor Stimulates the Activities of the raf -1 and the Mitogen Activated Protein Kinases via the trk Protooncogene." (1992) J. Biol. Chem. 267 , 14604.
  45. Ohmichi, M., Decker, S.J. and Saltiel, A.R . "Activation of Phosphatidylinositol 3-Kinase by Nerve Growth Factor Involves Indirect Coupling of the trk Protooncogene with src Homology 2 Domains." (1992) Neuron 9, 769.
  46. Ohmichi, M., Decker, S.J. and Saltiel, A.R . "Nerve Growth Factor Stimulates the Tyrosine Phosphorylation of a 38kD Protein that Specifically Associates with the src Homology Domain of Phospholipase C g -1." (1992) J. Biol. Chem. 267 , 21601.
  47. Zhu, G., Decker, S.J. and Saltiel, A.R. "Direct Analysis of the Binding of Src-homology 2 Domains of Phospholipase C to the Activated Epidermal Growth Factor Receptor." (1992) Proc. Natl. Acad. Sci. USA 89 , 9559.
  48. Pang, L., Decker, S.J. and Saltiel, A.R. "Bombesin and Epidermal Growth Factor Stimulate the Mitogen Activated Protein Kinase Through Different Pathways in Swiss 3T3 Cells." (1993) Biochem. J. 289 , 283.
  49. Zhu, G., Decker, S.J., Mayer, B.J. and Saltiel, A.R. "Direct Analysis of the Binding of the abl SH2 Domain to the Activated Epidermal Growth Factor Receptor." (1993) J. Biol. Chem. 268 , 1775.
  50. McNamara, D.J., Dobrusin, E.M., Zhu, G., Decker, S.J. and Saltiel, A.R. "Inhibition of Binding of Phospholipase C g 1 SH2 Domains to the Activated Epidermal Growth Factor Receptor by Phosphorylated Peptides." (1993) Int. J. Prot. Pep. Res. 42 , 240.
  51. Pearl , C. and Saltiel, A.R. "Metabolism of Glycosyl-Phosphoinositides in Mammalian Cells." (1993) Neuroprotocols 3 , 119.
  52. Pang, L., Lazar, D., Moller, D.E., Flier, J.S. and Saltiel, A.R. "The Stimulation of pp42 MAP Kinase by Insulin Does Not Correlate with its Metabolic Actions in Cells Overexpressing Mutant Insulin Receptors." (1993) Biochem. Biophys. Res. Comm. 196 , 301.
  53. Ohmichi, M., Pang, L., Ribon, V., Gazit, A., Levitski, A. and Saltiel, A.R. "The Tyrosine Kinase Inhibitor Tyrphostin Blocks the Cellular Actions of Nerve Growth Factor." (1993) Biochemistry 32 , 4650.
  54. Ohmichi, M., Pang, L., Ribon, V. and Saltiel, A.R. "Divergence of Signaling Pathways for Insulin in PC-12 Pheochromocytoma Cells." (1993) Endocrinology 133 , 46.
  55. Misek, D.M. and Saltiel, A.R. "An Inositol Phosphate Glycan Derived from a Trypanosoma Brucei Glycosyl-phosphatidylinositol Promotes Protein Dephosphorylation in Rat Epididymal Adipocytes." (1994) Endocrinology 135 , 1869
  56. Ohmichi, M., Zhu, G. and Saltiel, A.R. "Nerve Growth Factor Specifically Activates Protein Kinase C- e in PC-12 Rat Pheochromocytoma Cells." (1993) Biochem. J. 295 , 767.
  57. Rose, D.W., Saltiel. A.R. , Decker, S.J., Majumdar, M. and Olefsky. J.M. "IRS-1 is Required for Insulin-Mediated Mitogenic Signal Transduction." (1994) Proc. Natl. Acad. Sci. USA 91 , 797.
  58. Milarski, K.L., Zhu, G., Pearl , C.G., McNamara, D.J., Dobrusin, E.M., Maclean, D., Thieme-Sefler, A., Zhang, Z.-Y., Sawyer, T., Decker, S.J., Dixon , J.E. and Saltiel, A.R. "Sequence Specificity in Recognition of the Epidermal Growth Factor Receptor by Protein Tyrosine Phosphatase 1B" (1993) J. Biol. Chem. 268 , 23634.
  59. Ohmichi, M., Matuoka, K., Takenawa, T. and Saltiel, A.R. "Growth Factors Differentially Stimulate the Phosphorylation of Shc Proteins and Their Association with Grb2 in PC-12 Pheochromocytoma Cells" (1994) J. Biol. Chem. 269 , 1143.
  60. Lingwood , C.A. , Sakac, D. and Saltiel. A.R. "The Developmentally Regulated Testicular Galactolipid Sulfotransferase Inhibitor is a Phosphoinositol Glycerolipid and Insulin-mimetic." (1994) Mol. Reprod. Dev. 37 , 462.
  61. Ohmichi, M., Sawada, T., Kanda, Y., Koike, K., Hirota, K., Miyake, A. and Saltiel, A.R. "Thyrotropin Releasing Hormone Stimulates MAP Kinase Activity in GH3 Cells by Divergent Pathways." (1994) J. Biol. Chem. 269, 3783.
  62. Zheng, C-F., Ohmichi, M., Saltiel, A.R. and Guan, K-L. "Growth Factor Induced MEK Activation is Primarily Mediated by an Activator Different from c- raf ." (1994) Biochemistry 33 , 5595.
  63. Staubs, P.A., Reichart, D.R., Saltiel, A.R., Milarski, K.L., Maegawa, H., Berhanu, P., Olefsky, J.M. and Seely, B.L. "Localization of the Insulin Receptor Binding Sites for the SH2 Domain Proteins p85, Syp and GAP." (1994) J. Biol. Chem. 269 , 27186
  64. Zhu, G., Decker, S.J., MacLean, D., McNamara, D.J., Singh, J., Sawyer, T.K. and Saltiel, A.R. "Sequence Specificity in the Recognition of the Epidermal Growth Factor Receptor by the abl Src Homology 2 Domain." (1994) Oncogene 9 , 1379.
  65. Ribon, V., Leff, T. and Saltiel, A.R. "C-Myc Does Not Require Max for Transcriptional Activity in PC-12 Cells." (1994) Mol. Cell. Neurosci. 5 , 277.
  66. Pang, L., Milarski, K.L., Ohmichi, M., Takata, Y., Olefsky, J.M. and Saltiel, A.R. "Mutation of the Two Carboxy-Terminal Tyrosines in the Insulin Receptor Results in Enhanced Activation of Mitogen Activated Protein Kinase." (1994) J. Biol. Chem. 269 , 10604.
  67. Sasaoka,T., Rose, D.W., Jhun, B.H., Saltiel, A.R. , Draznin, B. and Olefsky, J.M. "Evidence for a Functional Role of Shc Proteins in Mitogenic Signaling Induced by Insulin, Insulin Like Growth Factor-1 and Epidermal Growth Factor." (1994) J. Biol. Chem. 269 , 13689.
  68. Jhun, B.H., Rose, D.W., Seely, B.L., Rameh, L., Cantley, L., Saltiel, A.R. and Olefsky, J.M. "Microinjection of the SH2 Domain of the 85kDa Subunit of Phosphatidylinositol 3-Kinase Inhibits Insulin-Induced DNA Synthesis and c-Fos Expression." (1994) Mol. Cell. Biol. 14 , 7466
  69. Mastick, C.C., Kato, H., Roberts, C.T., LeRoith, D. and Saltiel, A.R. "Insulin and Insulin Like Growth Factor I Receptors Similarly Stimulate DNA Synthesis Despite Differences in Cellular Protein Tyrosine Phosphorylation" (1994) Endocrinology 135 , 214.
  70. Pang, L., Zhang, C-F., Guan, K-L. and Saltiel, A.R. "Nerve Growth Factor Stimulates a Novel Protein Kinase in PC-12 Cells That Phosphorylates and Activates MEK." (1995) Biochem. J. 307 , 513
  71. Yamauchi. K., Milarski, K.L., Saltiel, A.R. and Pessin, J.E. "Tyrosine Specific Protein Phosphatase SHPTP2 is a Required Positive Effector of Insulin Downstream Signaling." (1995) Proc. Natl. Acad. Sci. USA 92 , 664
  72. Milarski, K.L. and Saltiel, A.R. "Expression of Catalytically Inactive SYP Phosphatase in 3T3 Cells Blocks the Stimulation of MAP Kinase by Insulin." (1994) J. Biol. Chem. 269 , 21239.
  73. Milarski, K.L., Lazar, D.F., Weise, R.J. and Saltiel, A.R. "Detection of a 60kD Tyrosine Phosphorylated Protein in Insulin-Stimulated Hepatoma Cells that Associates with the SH2 Domain of Phosphatidylinositol 3-Kinase." (1995) Biochem. J. 308 , 579
  74. Lazar, D.F., Knez, J.J., Medof , M.E. , Cuatrecasas, P. and Saltiel, A.R. "The Stimulation of Glycogen Synthesis by Insulin in Human Erythroleukemia Cells Requires the Synthesis of Glycosyl-Phosphatidylinositol." (1994) Proc. Natl. Acad. Sci. USA 91 , 9665
  75. Gergel, J.R., McNamara, D.J., Dobrussin, E.M., Zhu, G., Saltiel, A.R. and Miller, W.T. "Identification of Amino Acids in the N-terminal SH2 Domain of Phospholipase C g 1 Important in the Interaction with Epidermal Growth Factor Receptor." (1995) Biochemistry 33 , 14671.
  76. Maclean, D., Thieme-Sefler, A.M., Zhu, G., Decker, S.J., Saltiel, A.R. , Singh, J., McNamara, D., Dobrussin, E.M. and Sawyer, T.K. "Differentiation of Peptide Molecular Recognition by Phospholipase C g 1 Src Homolgy-2 Domain and a Mutant Tyrosine Phosphatase." (1995) Protein Science 4 , 13
  77. Pandey, A., Lazar, D.F., Saltiel, A.R. and Dixit, V.M. "Activation of the Eck Receptor Protein Tyrosine Kinase Stimulates Phosphatidylinositol 3-Kinase Activity." (1994) J. Biol. Chem. 269 , 30154.
  78. Sheela Rani, C.S., Abe, A., Chang, Y., Rosenzweig, N., Saltiel, A.R. , Radin , N.S. and Shayman, J.A. "Cell Cycle Arrest Induced by an Inhibitor of Glucosylceramide Synthase: Correlation with Cyclin-dependent Kinases." (1995) J. Biol. Chem. 270 , 2859.
  79. Wiese, R.J., Mastick, C.C., Lazar, D.F. and Saltiel, A.R. "Activation of MAP Kinase and Phosphatidylinositol 3'Kinase is not Sufficient for the Hormonal Stimulation of Glucose Uptake, Lipogenesis or Glycogen Synthesis in 3T3-L1 Adipocytes." (1995) J. Biol. Chem. 270 , 3442.
  80. Jhun, B.H., Haruta, T., Meinkoth, J.L., Leitner, J.W., Draznin, B., Saltiel, A.R. , Pang, L., Sasaoka, T. and Olefsky, J.M. "Signal Transduction Pathways Leading to Insulin-Induced Early Gene Expression." (1995) Biochemistry 34 , 7996
  81. Mastick, C.C., Brady, M.J. and Saltiel, A.R. "Insulin Stimulates the Tyrosine Phosphorylation of Caveolin." (1995) J. Cell Biol. 129 , 1523
  82. Pang, L., Sawada, T., Decker, S.J. and Saltiel, A.R. "Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by NGF." (1995) J. Biol. Chem. 270 , 13585
  83. Dudley , D.T., Pang, L., Decker, S.J., Bridges, A.J. and Saltiel, A.R. "Identification of a Synthetic Inhibitor of the MAP Kinase Cascade." (1995) Proc. Natl. Acad. Sci. USA 92 , 7686
  84. Yamauchi, K., Ribon, V., Saltiel, A.R. and Pessin, J.E. "Identification of the Major SHPTP2-binding Protein that is Tyrosine Phosphorylated in Response to Insulin." (1995) J. Biol. Chem. 270 , 17716
  85. Lazar, D.F., Brady, M.J., Weise, R.J., Mastick, C.C., Waters, S.B., Yamauchi, K., Pessin, J.E., Cuatrecasas, P. and Saltiel, A.R. "MEK Inhibition Does Not Block the Stimulation of Glucose Utilization by Insulin." (1995) J. Biol. Chem. 270 , 20801
  86. Alessi, D.R., Cuenda, A., Cohen, P., Dudley , D.T. and Saltiel, A.R. "PD98059 is a Specific Inhibitor of the Activation of MAP Kinase Kinase in vitro and in vivo ". (1995) J. Biol. Chem. 270 , 27489
  87. Lin, T-A, Kong, X., Saltiel, A.R. , Blackshear, P.J. and Lawrence, Jr, J.C. "Control of PHAS-1 by Insulin in 3T3-L1 Adipocytes: Synthesis, Degradation and Phosphorylation by a Rapamycin-Sensitive and MAP Kinase-Independent Pathway". (1995) J. Biol. Chem. 270 , 18531
  88. Waters, S.B., Holt, K.H., Ross, S.E., Syu, L-J., Guan, K-L., Saltiel, A.R. , Koretsky, G.A. and Pessin, J.E. "Desensitization of Ras Activation by a Feedback Disassociation of the SOS-Grb2 Complex" (1995) J. Biol. Chem. 270 , 20883
  89. Ribon, V. and Saltiel, A.R. "Nerve Growth Factor Stimulates the Tyrosine Phosphorylation of Endogenous Crk-II and its Association with p130 cas in PC-12 Cells." (1996) J. Biol. Chem. 271, 7375
  90. Holt, K.H., Waters, S.B., Okada, S., Yamauchi, K., Decker, S.J., Saltiel, A.R. , Motto, D.G., Koretsky, G.A. and Pessin, J.E. "Epidermal Growth Factor Receptor Targeting Prevents Uncoupling of the Grb2-SOS Complex." (1996) J. Biol. Chem. 271 , 8300
  91. Seely, B.L., Reichart, D.R., Staubs, P.A., Jhun, B.H., Hsu, D., Maegawa, H., Milarski, K.L., Saltiel, A.R. and Olefsky, J.M. "Localization of the Insulin-like Growth Factor I Binding Sites for the SH2 Domain Proteins p85, Syp and GTPase Activating Protein." (1995) J. Biol. Chem. 270 , 19151
  92. Sasaoka, T., Langolis, W.J., Bai, F., Rose, D.W., Leitner, J.W., Decker, S.J., Saltiel, A.R. , Gill, G.N., Kobayashi, M., Draznin, B. and Olefsky, J.M. "Involvement of ErbB2 in the Signaling Pathways Leading to Cell Cycle Progression from a Truncated Epidermal Growth Factor Receptor Lacking the C-Terminal Autophosphorylation Sites." (1996) J. Biol. Chem. 271 , 8338
  93. Langolis, W.J., Sasaoka, T., Saltiel, A.R. and Olefsky, J.M. "Negative Feedback Regulation and Desensitization of Insulin- and EGF-Stimulated p21 ras Activation." (1995) J. Biol. Chem. 270 , 25320
  94. Seely B.L., Staubs, P.A., Reichart, D.R., Berhanu, P., Milarski, K.L., Saltiel, A.R. , Kusari, J. and Olefsky, J.M. "Protein Tyrosine Phosphatase 1B Interacts with the Activated Insulin Receptor." (1996) Diabetes 45, 1379
  95. Ribon, V., Hubbell, S., Herrera, R. and Saltiel, A.R . "The Product of the Cbl Oncogene Forms Stable Complexes in vivo with Endogenous Crk in a Tyrosine Phosphorylation-Dependent Manner." (1996) Mol. Cell. Biol. 16 , 45
  96. Sawada, T., Milarski, K.L. and Saltiel, A.R. "Expression of a Catalytically Inert Syp Blocks Activation of the MAP Kinase Pathway Downstream of p21 ras " (1995) Biochem. Biophys. Res. Commun. 214 , 737
  97. Azpiazu, I. , Saltiel, A.R. , DePaoli-Roach, A.A. and Lawrence , J.C. Jr. "Regulation of Both Glycogen Synthase and PHAS-1 by Insulin in Rat Skeletal Muscle Involves MAP Kinase-Independent and Rapamycin-Sensitive Pathways." (1996) J. Biol. Chem. 271 , 5033
  98. Thornton , K.H., Muehller, W.T., McConnell, P., Zhu, G., Saltiel, A.R. and Thanabal, V. "NMR Solution Structure of Growth Factor Receptor-Bound Protein 2 (Grb2) SH2 Domain." (1996) Biochemistry 35 , 11852
  99. O'Rourke, C.M., Davis , J.A., Saltiel, A.R. and Cornicelli, J. "Metabolic Effects of Troglitazone in the GK Rat, a Nonobese and Normolipidemic Rodent Model of NIDDM." (1997) Metabolism 46, 192
  100. Parrizas, M., Saltiel, A.R. and LeRoith, D. "Insulin-Like Growth Factor Inhibits Apoptosis Using the Phosphatidylinositol 3' Kinase Pathway and the MAP Kinase Pathway." (1997) J. Biol. Chem. 272 , 154
  101. Martin, S.S., Rose, D.W., Saltiel, A.R ., Klippel, A ., Williams. L.T. and Olefsky, J.M. "Phosphatidylinositol 3-Kinase is Necessary and Sufficient for Insulin-Stimulated Stress Fiber Breakdown." (1996) Endocrinology 137 , 5045
  102. Morrison, P, Saltiel, A.R. and Rosner, M.R. "Role of MAP Kinase Kinase in Regulation of the EGF Receptor by Protein Kinase C." (1996) J. Biol. Chem. 271 , 12891
  103. Ribon, V. and Saltiel, A.R. "Insulin Stimulates the Tyrosine Phosphorylation of c-Cbl in 3T3-L1 Adipocytes." (1997) Biochem. J. 324 , 839
  104. Shahripour, A., Plummer, M.S., Lunney, E.A., Para, K.S., Stankovic, C.J., Rubin, J.R., Humblet, C., Marks, J.S., Fergus, J.H., Herrera, R., Hubbell, S.E., Saltiel, A.R. and Sawyer, T.K. "Novel Phosphotyrosine Mimetics in the Design of Peptide Ligands for pp60 src SH2 Domain." (1996) Bioorg. Med. Chem. Let. 6, 1209
  105. Desdouits-Magnen, J., Desdouits, F., Takeda, S., Syu, L-J, Saltiel, A.R ., Buxbaum, J.D., Czernik, A.J., Nairn, A.C. and Greengard, P "Regulation of Secretion of Alzheimer Amyloid Precursor Protein by the MAP Kinase Cascade" J. Neurochem 70 , 524
  106. Downey , G.P., Butler , J.R., Tapper, H., Fialkow, L., Saltiel, A.R. , Rubin, B.B. and Grinstein, S "Importance of MEK in Neutrophil Microbicidal Responsiveness" (1998) J. Immun. 160 , 434
  107. Printen, J.A., Brady, M.J. and Saltiel, A.R. "PTG, a Protein Phosphatase 1 Binding Protein with a Role in Glycogen Metabolism" (1997) Science 275, 1475
  108. Groskopf, J.C., Syu, L-J, Saltiel, A.R. and Linzer, D.I.H. "Proliferin and Basic Fibroblast Growth Factor Induce Endothelial Cell Chemotaxis Through a G Protein-Coupled, MAP Kinase-Dependent Pathway" (1997) Endocrinology 138 , 2835
  109. Brady, M.J., Nairn, A.C. and Saltiel, A.R. "The Regulation of Glycogen Synthase by Protein Phosphatase 1 in 3T3-L1 Adipocytes: Evidence for a Role for DARPP-32 in Insulin Action" (1997) J. Biol. Chem. 272 , 19698
  110. Wartmann, M., Hofer, P., Turowski, P., Saltiel, A.R. and Hynes, N.E. "Negative Modulation of Membrane Localization of the Raf-1 Protein Kinase by Hyperphosphorylation." (1997) J. Biol. Chem. 272 , 3915
  111. Syu, L-J., Guan, K-L. and Saltiel, A.R . "Inducible Expression of a Mutant Form of MEK1 in Swiss 3T3 Cells" (1997) J. Cell. Biochem. 67 , 367
  112. Mastick, C.C., Brady, M.J., Printen, J.A., Ribon, V. and Saltiel, A.R. "Spatial Determinants of Specificity in Insulin Action" (1997) Mol. Cel. Biochem. 182 , 65
  113. Plummer, M.S., Lunney, E.A., Para, K.S., Shahripour, A., Stankovic, C.J., Humblet, C., Fergus, J.H., Marks, J.S., Herrera, R., Hubbell, S., Saltiel, A.R. and Sawyer, T.K. "Design of Peptidomimetic Ligands for the pp60src SH2 Domain" (1997) Bioorg. Med. Chem. 5 , 41-47
  114. Kim, B., Leventhal, P.S., Saltiel, A.R. and Feldman, E.L. "Insulin-like Growth Factor (IGF1)-Mediated Neurite Outgrowth in vitro Requires MAP Kinase Activation" (1997) J. Biol. Chem. 272 , 21268
  115. Mastick, C.C. and Saltiel, A.R. "Insulin-Stimulated Tyrosine Phosphorylation of Caveolin is Specific for the Differentiated Adipocyte Phenotype in 3T3-L1 Cells" (1997) J. Biol. Chem. 272 , 20706
  116. Brady, M.J., Printen, J.A., Mastick, C.C. and Saltiel, A.R. "The Role of PTG in the Regulation of Protein Phosphatase 1 Activity" (1997) J. Biol. Chem. 272 , 20198
  117. Su, T-Z, Wang, M., Saltiel, A.R. and Oxender, D.L. "Regulation of System A Amino Acid Transport in 3T3-L1 Adipocytes by Insulin" (1998) J. Biol. Chem. 273 , 3173
  118. Shahripour, A., Para, K.S., Plummer, M.S., Lunney, E.A., Holland, D.R., Rubin, J.R., Humblet, C., Fergus, J.H., Marks, J.S., Saltiel, A.R. and Sawyer, T.K. "Structure-Based Design of Novel, Dipeptide Ligands Targeting the pp60Src SH2 Domain" (1997) Bioorg. Med. Chem. Lett. 7 , 1107
  119. Pircher, T.J., Flores-Morales, A., Mui, A.L-F, Saltiel, A.R., Gustafsson, J-A and Haldosen, L-A "Mitogen-activated Protein Kinase Kinase Inhibition Decreases Growth Hormone Stimulated Transcription Mediated by STAT5" (1997) Mol. Cell. Endocrin. 133 , 169
  120. Su, T-Z, Wang, M., Oxender, D.L. and Saltiel, A.R. "Troglitazone Increases System A Amino Acid Transport in 3T3-L1 Cells" (1998) Endocrinology 139 , 832
  121. Ribon, V., Printen, J.A., Hoffman, N.G., Kay, B.K. and Saltiel, A.R . "A Novel, Multifunctional c-Cbl Binding Protein in Insulin Receptor Signaling in 3T3-L1 Adipocytes" (1998) Mol. Cell. Biol. 18 , 872
  122. Ribon, V., Herrera, R., Kay, B.K. and Saltiel, A.R . "A Role for CAP, a Novel Multifunctional SH3 Domain-Containing Protein in Formation of Actin Stress Fibers and Focal Adhesions" (1998) J. Biol. Chem. 273 , 4073
  123. Stankovic, C.J., Surendran, N., Lunney, E.A., Plummer, M.S., Para, K.S., Shahripour, A., Fergus, J.H., Marks, J.S., Herrera, R., Hubbell, S.E., Humblet, C., Saltiel, A.R., Stewart, B.H. and Sawyer, T.K. "The Role of 4-Phosphodifluoromethyl- and 4-Phosphono-phenylalanine in the Selectivity and Cellular Uptake of SH2 Domain Ligands" (1997) Bioorg. Med. Chem. Let. 7 , 1999
  124. Brady, M.J., Bourbonais, F.J. and Saltiel, A.R. "The Activation of Glycogen Synthase by Insulin Switches from Kinase Inhibition to Phosphatase Activation During Adipogenesis in 3T3-L1 Cells" (1998) J. Biol. Chem. 273 , 14063
  125. Kao, A.W., Noda, Y., Johnson, J.H., Pessin, J.E. and Saltiel, A.R. "Fructose 1,6 bisphosphate Aldolase Mediates the Association of F-Actin with the Insulin Responsive (GLUT4) Glucose Transporter" (1999) J. Biol. Chem. 274 , 17742
  126. Hansen, L., Fjordvang, H., Rasmussed, S.K., Vestergaard, H., Echwald, S.R., Hansen, T., Alessi, D., Shenolikar, S., Saltiel, A.R ., Barbetti, F. and Pedersen, O. "Mutational Analysis of the Genes Encoding Protein Kinase B a and b , Phosphoinositide Dependent Protein Kinase-1, Phosphatase Targeting to Glycogen, Protein Phosphatase Inhibitor-1 and Glycogenin: Lessons from a Genetic Study of the Insulin Stimulated Glycogen Synthesis Pathway of Skeletal Muscle in NIDDM Patients" (1999) Diabetes 48 , 403
  127. Nakashima, N., Rose, D.W., Xiao, S., Egawa, K., Martin, S.S., Haruta, T., Saltiel, A.R. and Olefsky, J.M. "The Functional Role of CrkII in Actin Cytoskeleton Organization and Mitogenesis" (1999) J. Biol. Chem. 274 , 3001
  128. Min, J., Okada, S., Coker, K., Ceresa, B.P., Elmendorf, J.S., Syu, L-J, Noda, Y., Saltiel, A.R . and Pessin, J.E. "Synip: A Novel Insulin-Regulated Syntaxin 4 Binding Protein Mediating Glut4 Translocation in Adipocytes" (1999) Molecular Cell 3 , 751
  129. Ribon, V., Johnson, J.H., Camp, H.S. and Saltiel, A.R . "Thiazolidinediones and Insulin Resistance: PPARgamma ?Activation Stimulates Expression of the CAP Gene" (1998) Proc. Natl. Acad. Sci. USA 95 , 14751
  130. Sebolt-Leopold, J.S., Dudley, D.T., Herrera, R., Van Beccelaere, K., Wiland, A., Gowan, R.C., Tecle, H., Barrett, S.D., Bridges, A., Przybranowski, S., Leopold, W.R. and Saltiel, A.R . "Blockade of the MAP Kinase Pathway Suppresses Growth of Colon Tumors In Vivo" (1999) Nature Medicine 5 , 810
  131. Syu, L-J and Saltiel, A.R . "Lipotransin, a Novel Docking Protein for Hormone Sensitive Lipase" (1999) Molecular Cell 4 , 109
  132. Brady, M.J., Kartha, P.M., Aysola, A.A. and Saltiel A.R . "The Role of Glucose Metabolites in the Activation and Translocation of Glycogen Synthase by Insulin in 3T3-L1 Adipocytes" (1999) J. Biol. Chem. 274 , 27497
  133. Brady, M.J., Pessin, J.E. and Saltiel, A.R. "Spatial Compartmentalization in the Regulation of Glucose Metabolism by Insulin" (1999) Trends in Endocrinology and Metabolism 10 , 408
  134. Baumann , C.A. , Chokshi, N., Saltiel, A.R . and Ribon, V. "Cloning and Characterization of a Functional PPARgamma Responsive Element in the Promoter of the CAP Gene" (2000) J. Biol. Chem. 275 , 9131
  135. Baumann , C.A. , Ribon, V., Bickel, P.E., Thurmond , D.C. , Kanzaki, M., Pessin, J.E. and Saltiel, A.R. "CAP Defines a Second Signaling Pathway Required for Insulin-Stimulated Glucose Transport" (2000) Nature 407 , 202
  136. Pessin, J.E. and Saltiel, A.R . "Signaling Pathways in Insulin Action: Molecular Targets of Insulin Resistance" (2000) J. Clin. Invest. 106 , 165
  137. Chiang, S-H, Baumann , C.A. , Kanzaki, M, Thurmond , D.C. , Neudauer, C.L., Macara, I.G., Pessin, J.E. and Saltiel, A.R . "Insulin-Stimulated GLUT4 Translocation Requires the CAP-Dependent Activation of TC10" (2001) Nature 410 , 944
  138. Fong , N.M. , Jensen, T.C., Shah, A.S., Parekh, N.N., Saltiel, A.R. and Brady, M.J. "Identification of Binding Sites on PTG for Enzymes of Glycogen Metabolism" (2000) J. Biol. Chem. 275 , 35054
  139. Baumann , C.A. , Brady, M.J. and Saltiel, A.R . "Activation of Glycogen Synthase by Insulin in 3T3-L1 Adipocytes Involved CAP-dependent and CAP-independent Signaling Pathways" (2001) J. Biol. Chem. 276 , 6065
  140. Skinner, J.A. and Saltiel, A.R . "Cloning and Identification of MYPT3: A Prenylatable Myosin Targeting Subunit of Protein Phosphatase 1" (2001) Biochem. J. 356 , 257
  141. Kimura, A., Baumann , C.A. , Chiang, S-H and Saltiel, A.R. "The Sorbin Homology ( SoHo ) Domain: a Motif for the Targeting of Proteins to Lipid Rafts" (2001) Proc. Natl. Acad. Sci. USA 98 , 9098
  142. Watson, R.T., Shigematsu, S., Chiang, S-H., Mora, S., Kanzaki, M., Macara, I.G., Saltiel, A.R., and Pessin, J.E. "Plasma Membrane Microdomain Compartmentalization of TC10 is Required for Insulin Signaling and GLUT4 Translocation" (2001) J. Cell. Biol. 154 , 829
  143. Chiang, S-H, Hou, J.C., Hwang, J., Pessin, J.E. and Saltiel, A.R. "Cloning and Functional Characterization of Related TC10 Isoforms, a Subfamily of Rho Proteins Involved in Insulin-Stimulated Glucose Transport" (2002) J. Biol. Chem. 277 , 13067
  144. Liu, J., Kimura, A., Bauman , C.A. and Saltiel, A.R. " APS Mediates c-Cbl Tyrosine Phosphorylation and GLUT4 Translocation in Response to Insulin in 3T3-L1 Adipocytes" (2002) Mol. Cell. Biol. 22 , 3599
  145. Kanzaki, M., Watson, R.T., Hou, J.C., Stamnes, M., Saltiel, A.R. and Pessin, J.E. "The Small GTP-Binding Protein TC10 Differentially Regulates Two Distinct Populations of Filamentous Actin in 3T3L1 Adipocytes" (2002) Mol. Biol. Cell 13 , 2334
  146. Kimura, A., Mora, S., Shigematsu , S., Pessin, J.E. and Saltiel, A.R . "The Insulin Receptor Catalyzes the Tyrosine Phosphorylation of Caveolin 1" (2002) J. Biol. Chem. 277 , 30153.
  147. Chang, L. Adams, R. and Saltiel, A.R. " The TC10-interacting Protein CIP4/2 is Required for Insulin-Stimulated Glut4 Translocation in 3T3L1 Adipocytes" (2002) Proc. Natl. Acad. Sci. USA 99 , 12835
  148. Watson, R.T., Furukawa, M., Chiang, S-H, Boeglin, D., Kanzaki, M., Saltiel, A.R . and Pessin, J.E. " The Exocytotic Trafficking of TC10 Occurs through both Classical and Nonclassical Secretory Transport Pathways in 3T3L1 Adipocytes " ( 2003) Mol. Cell. Biol. 23 , 961
  149. Zhang, M. Kimura, A. and Saltiel, A.R . Cloning and Characterization of CAP Splicing Isoforms" (2003) Mol. Med. 9 , 18
  150. Inoue, M., Chang, L., Hwang, J., Chiang, S-H, and Saltiel, A.R . "The Exocyst Complex is Required for Targeting of Glut4 to the Plasma Membrane by Insulin" (2003) Nature 422 , 629
  151. Crosson, S.M., Printen, J., Kahn, A., Pessin, J.E., and Saltiel, A.R . "PTG Gene Deletion Causes Impaired Glycogen Synthesis and Developmental Insulin Resistance" (2003) J. Clin. Invest. 111 : 1423
  152. Chiang, S-H, Hwang, J., Legendre, M., Zhang, M., Kimura A. and Saltiel, A.R. "TCGAP, A Multidomain Rho GTPase Activating Protein that Regulates Insulin-Stimulated Glucose Transport" (2003) EMBO J 22 , 2679
  153. Liu, J. DeYoung, S.M., Hwang, J., O'Leary, E. and. Saltiel, A.R. "The Roles of Cbl-b and c-Cbl in Insulin-Stimulated Glucose Transport" (2003)J. Biol. Chem. 278 , 36754
  154. Hu, J., Liu, J., Ghirlando, R., Saltiel, A.R., and Hubbard, S.R. "Structural Basis for Recruitment of the Adapter Protein APS to the Activated Insulin Receptor" (2003) Molecular Cell 12, 1379
  155. Kanzaki, M., Mora, S., Huang, J., Saltiel, A.R. and Pessin, J.E. "Atypical Protein Kinase C (PKCz/l) is a convergent downstream target of the insulin-stimulated phosphatidylinositol (PI) 3-kinase and TC10 signaling pathways" (2004) J. Cell Biol. 164, 279
  156. Voisine, P., Ruel, M., Khan, T.A., Bianchi, C., Xu, S-H, Kohane, I., Libermann, T.A., Out, H., Saltiel, A.R., and Selke, F.W. "Differences in Gene Expression Profiles of Diabetic and Non-Diabetic Patients Undergoing Cardiopulmonary Bypass and Cardioplegic Arrest" Circulation (2004) 110, 280-286
  157. Liu, J., DeYoung, S., Zhang, M., Dold L.H. and Saltiel, A.R. “The SPFH domain of flotillin-1 contains distinct sequences that direct plasma membrane localization and protein interactions in 3T3-L1 adipocytes” (2005) J. Biol. Chem. 280, 16125
  158. Liu, J., DeYoung, S.M., Zhang, M., Zhang, M. and Saltiel, A.R. “Changes in Integrin Expression During Adipocyte Differentiation” (2005) Cell Metabolism 2, 165 (feature cover article)
  159. Chun, T-W, Hotary, K.B., Sabeh, F., Saltiel, A.R., Holmeck, K., Birkedal-Hansen, H., Allen, E.D., and Weiss, S.J. “A pericellular collagenase directs the 3-dimensional development of white adipose tissue” (2006) Cell 5, 125
  160. Inoue, M., Chiang, S-H, Chang, L., Chen, X-W and Saltiel, A.R. “Compartmentalization of the Exocyst Complex in Lipid Rafts Controls Glut4 Vesicle Tethering” (2006) Mol Biol. Cell 17, 2303
  161. Cheng, A., Zhang, M., Crosson, S., Bao, A. and Saltiel, A.R. “Regulation of the PTG promoter by the FoxA2 forkhead protein and by cAMP in hepatoma cells” (2006) Endocrinology 147, 3606
  162. Kawase, K., Nakamura, T., Takaya, A., Aoki, K., Namikawa, K., Kiyama, H., Inagaki, S., Takemoto, H., Saltiel, A.R. and Matsuda, M “Down Regulation of TC10 Activity Precedes Vesicular Fusion” (2006) Developmental Cell 11, 411
  163. Su, X. Lodhi, I.J., Saltiel, A.R. and Stahl, P.D. “Insulin-stimulated interaction between insulin receptor substrate-1 and p85 and activation of protein kinase B/Akt require Rab5” (2006) J. Biol. Chem. 281, 27982

Review Articles

  1. Low, M. G. and Saltiel, A. R. "Structural and Functional Roles of Glycosyl-Phosphatidylinositol in Biological Membranes." (1988) Science 239 , 268.
  2. Saltiel, A. R. and Cuatrecasas, A. R. "In Search of a Second Messenger for Insulin." (1988) Am. J. Physiol. 255 , C1.
  3. Saltiel, A. R. , Osterman, D. G., Darnell, J. C., Sorbara-Cazan, L. R., Chan, B. L., Low, M. G., and Cuatrecasas, P. "The Function of Glycosyl-Phosphoinositides in Hormone Action." (1988) Phil. Trans. Roy. Soc. London B 320 , 345.
  4. Saltiel, A.R. , "Second Messengers of Insulin Action." (1990) Trends Endocrin. Metab. 1 , 158.
  5. Saltiel, A.R. "The Role of Glycosyl-phosphoinositides in Hormone Action." (1991) J. Bioenerg. Biomem. 23 , 29.
  6. Saltiel, A.R. "Transmembrane Signaling in Insulin Action." (1990) J. Nutrit. Biochem. 1 , 180.
  7. Saltiel, A.R. "Second Messengers of Insulin Action." (1990) Diabetes Care 13 , 244.
  8. Saltiel, A.R . and Decker, S.J. "Diversity in Cellular Signaling for Nerve Growth Factor and Insulin: Variations on a Common Theme." (1991) Mol. Cell. Endo. 81 , C197.
  9. Saltiel, A.R. and Decker, S.J. "Diversity in Cellular Signaling for Insulin and NGF" (1992) J. Invest. Dermatol. 98 , 17S.
  10. Saltiel, A.R. and Ohmichi, M. "Pleiotropic Functions of Receptor Tyrosine Kinases." (1993) Current Opinions Neurobiol 3 , 352.
  11. Saltiel, A.R. and Decker, S.J. "Cellular Mechanisms of Signal Transduction for Neurotrophins" (1994) Bioessays 16 , 405.
  12. Saltiel, A.R. "The Paradoxical Regulation of Protein Phosphorylation in Insulin Action" (1994) FASEB J. 8, 1034.
  13. Saltiel, A.R. "Structural and Functional Roles of Glycosyl-Phosphoinositides" (1996) Subcellular Biochemistry 26 , 165
  14. Saltiel, A.R. and Horikoshi, H. "Thiazolidinediones are Novel Insulin-Sensitizing Agents" (1995) Cur. Opin. Endocrin. Diabet. 2 , 341
  15. Saltiel, A.R. "Diverse Pathways of Signal Transduction in Insulin Action" (1996) Am. J. Physiol. 270, E375
  16. Saltiel, A.R . "Signal Transduction Pathways as Drug Targets". (1995) Scientific American: Science and Medicine 2 , 58
  17. Whitcomb, R.W. and Saltiel, A.R. "Thiazolidinediones" (1995) Exp. Opin. Invest. Drugs 4 , 1299
  18. Saltiel, A.R. and Olefsky, J.M. "Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes" (1996) Diabetes 45 , 1661
  19. Saltiel, A.R. and Sawyer, T. "Targeting Signal Transduction in the Discovery of Antiproliferative Drugs" (1996) Chemistry and Biology 3 , 887
  20. Brady, M.J. and Saltiel, A.R . "Insulin and Glucagon" in Encyclopedia of Life Sciences Macmillan Ref.
  21. Brady, M.J. and Saltiel, A.R. "Closing in on the Cause of Insulin Resistance and Type 2 Diabetes" (1999) J. Clin. Invest. 104 , 675
  22. Olefsky, J.M. and Saltiel, A.R . "PPARgamma and the Treatment of Insulin Resistance" (2000) Trends Endocrin. Met. 11 , 362
  23. Saltiel, A.R . " Another Hormone Sensitive Triglyceride Lipase in Fat Cells?" (2000) Proc. Natl. Acad. Sci. USA 97 , 535.
  24. Baumann , C.A. and Saltiel, A.R . "Spatial Compartmentalization of Signaling Molecules in Insulin Action" (2001) Bioessays 23 , 215
  25. Brady, M.J. and Saltiel, A.R. "The Role of Protein Phosphatase 1 in Insulin Action" (2001) Rec. Prog. Horm. Act. 57 , 157
  26. Newgard, C.B., Brady, M.J., O'Doherty, R.M. and Saltiel, A.R. "Organizing Glucose Disposal: The Emerging Roles of the Glycogen Targeting Subunits of Protein Phosphatase 1" (2000) Diabetes 49 , 1967
  27. Saltiel, A.R . "New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes" (2001) Cell 104 , 517
  28. Saltiel, A.R. "You Are What You Secrete" (2001) Nature Medicine 7 , 887
  29. Saltiel, A.R. and Kahn, C.R. "Insulin Signaling and the Regulation of Glucose and Lipid Metabolism" (2001) Nature 414 , 789
  30. Saltiel, A.R . and Pessin, J.E. "Insulin Signaling Pathways in Time and Space" (2002) Trends in Cell Biology 12 , 65
  31. Saltiel, A.R. "Muscle or Fat? Rho Bridges the GAP" (2003) Cell 113 , 144
  32. Saltiel, A.R . and Pessin, J.E. "Insulin signaling in microdomains of the plasma membrane" (2003) Traffic 4 , 711
  33. Saltiel, A.R. "Tugging on Glucose Transport" (2003) Nature Medicine 9 , 1352
  34. Saltiel, A.R. " Putting the Breaks on Insulin Signaling" New Eng J Med. 349, 26
  35. Decker, S.J. and Saltiel, A.R. “Staying in SHIP Shape” (2005) Nature Medicine 11, 123
  36. Saltiel, A.R. “Holding the line on Hepatic Fat” (2005) Cell Metabolism 2, 1
  37. Chang, L., Chiang, S-H, and Saltiel, A.R. “Insulin Signaling and the Regulation of Glucose Transport” Mol. Med. (2005) 10, 65
  38. Cheng, A and Saltiel, A.R. “More TORC for the Gluconeogenic Engine” Bioessays (2006) 28, 231
  39. Lazar, D.F., and Saltiel, A.R. “Lipid Phosphatases as Drug Targets for Type 2 Diabetes” Nat Rev Drug Discovery (2006) 5, 333
  40. Lumeng, C. and Saltiel, A.R. “Insulin signaling gives autophagy a push” Autophagy (2006) 2, 250

Articles accepted for publication

  1. Pessin, J.E. and Saltiel, A.R . "Molecular basis for insulin receptor signaling specificity". Biochemical Society Transactions. (in press)
  2. Hou, J.C., Saltiel, A.R . and Pessin, J.E. "Cellular and Molecular Processes Regulating GLUT4 translocation" Diabetes Mellitus ed. J Olefsky (in press)
  3. Watson, R.T., Saltiel, A.R., Pessin, J.E. and Kanzaki, M. “Subcellular Compartmentalization of Insulin Signaling Processes and GLUT4 Trafficking Events” Insulin Action ed. AR Saltiel and JE Pessin Landes Biopress (in press)
  4. Lumeng, C.N., DeYoung, S.M. and Saltiel, A.R. “Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins” (2006) Am. J. Physiol. (in press)
  5. Chen, X-W, Inoue, M., Hsu, S-C and Saltiel, A.R. “RalA-exocyst dependent recycling endosome trafficking is required for the completion of cytokinesis” (2006) J. Biol. Chem. (in press)
  6. Zhang, M., Liu, J., DeYoung, S.M., Cheng, A., Chen, X-W, Dold, L.H. and Saltiel, A.R. “CAP interacts with cytoskeletal proteins and regulates adhesion-mediated ERK activation and motility” (2006) EMBO J. (in press)
  7. Lumeng, C.N., Bodzin, J.L. and Saltiel, A.R. “Obesity induces a phenotypic switch in adipose tissue macrophage polarization" (2006) J. Clin. Invest. (in press)
  8. Chang, L., Chiang, S-H, and Saltiel, A.R. “TC10 is Required for Insulin-Stimulated Glucose Uptake in Adipocytes” (2006) Endocrinology (in press)
  9. Lumeng, C.N., DeYoung, S.M., Bodzin, J.L. and Saltiel, A.R. “Increased inflammatory properties of adipose tissue macrophages recruited during diet induced obesity” (2006) Diabetes (in press)

Chapters in Books

  1. Saltiel, A. R. "Preparation and Characterization of Putative Insulin Mediators from Liver." (1984) Methods in Diabetes Research Vol. I, 73.
  2. Saltiel, A.R . "A Role for Novel Glycosylated Phosphoinositides in Insulin Action." Inositol Lipids in Cellular Signaling. (1987) pp. 107-112. Cold Spring Harbor Press.
  3. Saltiel, A.R . "Post-receptor Defects in NIDDM: Second Messengers." Pathogenesis and New Approaches to the Study of Noninsulin-Dependent Diabetes Mellitus. (1988) Alan R. Liss, Progress in Clinical and Biological Research. 265, 43.
  4. Saltiel, A. R. "Pleiotropic Functions of the Insulin Receptor." in Molecular Mechanisms of Cellular Growth and Differentiation. P & S Biomedical Sciences Symposium. (1991) pp59-67.
  5. Saltiel, A. R . "Transmembrane Signalling in Insulin Action." (1988) in Molecular and Cellular Biology of Diabetes Mellitus.Vol II ed B. Draznin, D. Le Roith, S. Melmed, Alan R. Liss, N.Y. pp107-116.
  6. Saltiel, A.R ., Osterman, D.G. and Darnell, J.C. "The Role of Glycosyl-Phosphoinositides in Insulin Action." (1988) Cold Spring Harbor Symp. Quan. Biol. 53, 955.
  7. Saltiel, A.R. and Cuatrecasas, P. "Second Messengers of Insulin Action" (1990) Hand. Exptl. Pharm. ed. S. Jacobs and P. Cuatrecasas 92, 289.
  8. Saltiel, A.R., Osterman, D.G., Darnell, J.C., Chan, B.L. and Sorbara-Cazan, L.R. "The Role of Glycosyl-Phosphoinositides in Signal Transduction." (1989) Recent Prog. Hormone Action 45, 353.
  9. Saltiel, A.R . "The Role of Glycosyl-Phosphoinositides in Hormone Action." in Biology of Cellular Transducing Signals '89, ed. J. Y. Vanderhoek, Plenum Press, (1990) pp 391-401.
  10. Saltiel, A.R . "The Role of Glycosyl-Phosphatidylinositol in Hormone Action." in Molecular and Cell Biology of Membrane Proteins (1990) ed. A.J. Turner, Ellis Horwood Inc. pp166-180.
  11. Misek, D.M. and Saltiel, A.R. "The Role of Protein Phosphorylation in Insulin Action." (1995) in Clinical Science of Diabetes (ed. R.D.G. Leslie and D.C. Robbins) pp 61-76.
  12. Whitcomb, R.W., Saltiel, A.R . and Lockwood, D.H. "New Therapies for NIDDM: Thiazolidinediones" in Diabetes Mellitus, A Fundamental and Clinical Text (ed. D. LeRoith, J.M. Olefsky and S.E. Taylor) Lippincott-Raven (1996) pp661-668.
  13. Saltiel, A.R . "Cellular Mechanisms of Signal Transduction for Growth Factors" Advances in Molecular and Cellular Endocrinology (ed. D. LeRoith) 2, 83
  14. Dudley, D.T. and Saltiel, A.R . "A Pharmacological Approach to the MAP Kinase Cascade" (1999) in Signal Transduction and Cell Cycle Inhibitors ed. S. Gutkind p467
  15. Saltiel, A.R. "Signal Transduction" (1999) in Encyclopedia of Molecular Biology.
  16. Johnson, J.H., Saltiel, A.R ., and Leff, T. "Pharmacological Approaches to Insulin Resistance in the Zucker Diabetic Fatty Rat" In: Frontiers in Animal Diabetes Research. (2000) Vol. 3 Eds. Grunberger, G., and Zick Y., Harwood Academic Press pp331-343
  17. Pessin, J.E. and Saltiel, A.R . "Insulin-Stimulated Glut4 Trafficking in Adipocytes: Lessons Learned from Synaptic Transmission: in Adipocyte Biology and Hormone Signaling (ed. J. Ntambi) IOS press (2000)
  18. Foyt, H.L. Ghazzi, M.N., Hanley, R.M. Saltiel, A.R . and Whitcomb, R.W. "New Therapies for NonInsulin-Dependent Diabetes Mellitus: Thiazolidinediones" in Diabetes Mellitus, A Fundamental and Clinical Text (ed. D. LeRoith, J.M. Olefsky and S.E. Taylor) Lippincott-Raven
  19. Okada, S. Crosson, S., Masatomo, M., Saltiel, A.R . and Pessin, J.E. "Post Receptor Mechanisms of Insulin Action" in Encyclopedia of Endocrinology and Endocrine Diseases, Elsevier Press
  20. Kahn, C.R. and Saltiel, A.R. “The Molecular Mechanism of Insulin Action and the Regulation of Glucose and Lipid Metabolism” in Joslin's Diabetes Mellitus, Fourteenth Edition (ed. C.R. Kahn, G.C. Weir, G.L. King, A.M. Jacobson, A.C. Moses and R.J. Smith) Lippincott Williams and Wilkins (2005)
  21. Chiang, S-H, Chang, L. and Saltiel, A.R. “TC10 and Insulin-Stimulated Glucose Transport” Methods in Enzymology (ed. W.E. Balch, C.J. Der, and A. Hall) 406, 701

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