Publications

Recent Articles | Articles (1998-2004) | Articles (1991-1997) | Articles (1974-1990) | Review Articles | Editorial Material | Letters | Notes

Recent Articles

Liptak, M.D., Fleischhacker, A.S., Matthews, R.G., & Brunold, T.C. (2007). Probing the role of the histidine 759 ligand in cobalamin-dependent methionine synthase. Biochemistry 46, 8024-35. PubMed Link

Elmore, C.L., Wu, X., Leclerc, D., Watson, E.D., Bottiglieri, T., Krupenko, N.I., Krupenko, S.A., Cross, J.C., Rozen, R., Grave, R.A., Matthews, R.G. (2007). Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Mol Genet Metab. 91, 85-97. PubMed Link

Paul, L., Mishra, P.K., Blumenthal, R.M., & Matthews, R.G. (2007). Integration of regulatory signals through involvement of multiple global regulators: control of the Escherichia coli gltBDF operon by Lrp, IHF, Crp, and ArgR. BMC Microbiol. 18, 2. PubMed Link

Chapman, E., Farr, G.W., Usaite, R., Furtak, K., Fenton, W.A., Chaudhuri, T.K., Hondorp, E.R., Matthews, R.G., Wolf, S.G., Yates, J.R., Pypaert, M., Horwich, A.L. (2006). Global aggregation of newly translated proteins in an Escherichia coli strain deficient of the chaperonin GroEL. Proc Natl Acad Sci U S A 103, 15800-5. PubMed Link

Pejchal, R., Campbell, E., Guenther, B. D., Lennon, B. W., Matthews, R. G., & Ludwig, M. L. (2006). Structural perturbations in the Ala -> Val polymorphism of methylenetetrahydrofolate reductase: How binding of folates may protect against inactivation. Biochemistry, 45, 4808-4818. PubMed Link

Taurog, R. E., Jakubowski, H., & Matthews, R. G. (2006). Synergistic, random sequential binding of substrates in cobalamin-independent methionine synthase. Biochemistry, 45, 5083-5091. PubMed Link

Taurog, R. E., & Matthews, R. G. (2006). Activation of methyltetrahydrofolate by cobalamin-independent methionine synthase. Biochemistry, 45, 5092-5102. PubMed Link

Yamada, K., Gravel, R. A., Toraya, T., & Matthews, R. G. (2006). Human methionine synthase reductase is a molecular chaperone for human methionine synthase. Proceedings of the National Academy of Sciences of the USA, 103, 9476-9481. PubMed Link

Yamada, K., Strahler, J. R., Andrews, P. C., & Matthews, R. G. (2005). Regulation of human methylenetetrahydrofolate reductase by phosphorylation. Proceedings of the National Academy of Sciences of the USA, 102, 10454-10459. PubMed Link

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Articles (1998-2004)

Hondorp, E. R., & Matthews, R. G. (2004). Oxidative stress inactivates cobalamin-independent methionine synthase (MetE) in Escherichia coli. PLOS Biology, 2, 1738-1753.

Evans, J. C., Huddler, D. P., Hilgers, M. T., Romanchuk, G., Matthews, R. G., & Ludwig, M. L. (2004). Structures of the N-terminal modules imply large domain motions during catalysis by methionine synthase. Proceedings of the National Academy of Sciences of the USA, 101, 3729-3736. PubMed Link

Kacprzak, M. M., Lewandowska, I., Matthews, R. G., & Paszewski, A. (2003). Transcriptional regulation of methionine synthase by homocysteine and choline in Aspergillus nidulans. Biochemical Journal, 376, 517-524. PubMed Link

Dorweiler, J. S., Finke, R. G., & Matthews, R. G. (2003). Cobalamin-dependent methionine synthase: Probing the role of the axial base in catalysis of methyl transfer between methyltetrahydrofolate and exogenous Cob(I)alamin or Cob(I)inamide. Biochemistry, 42, 14653-14662. PubMed Link

Matthews, R. G., Smith, A. E., Zhou, Z. H. S., Taurog, R. E., Bandarian, V., Evans, J. C., & Ludwig, M. (2003). Cobalamin-dependent and cobalamin-independent methionine synthases: Are there two solutions to the same chemical problem? Helvetica Chimica Acta, 86, 3939-3954. PubMed Link

Bandarian, V., Ludwig, M. L., & Matthews, R. G. (2003). Factors modulating conformational equilibria in large modular proteins: A case study with cobalamin-dependent methionine synthase. Proceedings of the National Academy of Sciences of the USA, 100, 8156-8163. PubMed Link

Matthews, R. G. (2002). Methylenetetrahydrofolate reductase: A common human polymorphism and its biochemical implications. Chemical Record, 2, 4-12. PubMed Link

Dorweiler, J. S., Matthews, R. G., & Finke, R. G. (2002). Providing a chemical basis toward understanding the histidine base-on motif of methylcobalamin-dependent methionine synthase: An improved purification of methylcobinamide, plus thermodynamic studies of methylcobinamide binding exogenous imidazole and pyridine bases. Inorganic Chemistry, 41, 6217-6224. PubMed Link

Bandarian, V., Pattridge, K. A., Lennon, B. W., Huddler, D. P., Matthews, R. G., & Ludwig, M. L. (2002). Domain alternation switches B-12 dependent methionine synthase to the activation conformation. Nature Structural Biology, 9, 53-56. PubMed Link

Tani, T. H., Khodursky, A., Blumenthal, R. M., Brown, P. O., & Matthews, R. G. (2002). Adaptation to famine: A family of stationary-phase genes revealed by microarray analysis. Proceedings of the National Academy of Sciences of the USA, 99, 13471-13476. PubMed Link

Peariso, K., Zhou, Z. H. S., Smith, A. E., Matthews, R. G., & Penner-Hahn, J. E. (2001). Characterization of the zinc sites in cobalamin-independent and cobalamin-dependent methionine synthase using zinc and selenium X-ray absorption spectroscopy. Biochemistry, 40, 987-993. PubMed Link

Bandarian, V., & Matthews, R. G. (2001). Quantitation of rate enhancements attained by the binding of cobalamin to methionine synthase. Biochemistry, 40, 5056-5064. PubMed Link

Trimmer, E. E., Ballou, D. P., & Matthews, R. G. (2001). Methylenetetrahydrofolate reductase from Escherichia coli: Elucidation of the kinetic mechanism by steady-state and rapid-reaction studies. Biochemistry, 40, 6205-6215. PubMed Link

Trimmer, E. E., Ballou, D. P., Ludwig, M. L., & Matthews, R. G. (2001). Folate activation and catalysis in methylenetetrahydrofolate reductase from Escherichia coli: Roles for Aspartate 120 and Glutamate 28. Biochemistry, 40, 6216-6226. PubMed LInk

Paul, L., Blumenthal, R. M., & Matthews, R. G. (2001). Activation from a distance: Roles of Lrp and integration host factor in transcriptional activation of gltBDF. Journal of Bacteriology, 183, 3910-3918. PubMed Link

Hall, D. A., Kooi, C. W. V., Stasik, C. N., Stevens, S. Y., Zuiderweg, E. R. P., & Matthews, R. G. (2001). Mapping the interactions between flavodoxin and its physiological partners flavodoxin reductase and cobalamin-dependent methionine synthase. Proceedings of the National Academy of Sciences of the USA, 98, 9521-9526. PubMed link

Yamada, K., Chen Z. T., Rozen, R., & Matthews, R. G. (2001). Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase. Proceedings of the National Academy of Sciences of the USA, 98, 14853-14858. PubMed Link

Hall, D. A., Jordan-Starck, T. C., Loo, R. O., Ludwig, M. L., & Matthews, R. G. (2000). Interaction of flavodoxin with cobalamin-dependent methionine synthase. Biochemistry, 39, 10711-10719. PubMed

Smith, A. E., & Matthews, R. G. (2000). Protonation state of methyltetrahydrofolate in a binary complex with cobalamin-dependent methionine synthase. Biochemistry, 39, 13880-13890. PubMed Link

Zhou, Z. S., Smith, A. E., & Matthews, R. G. (2000). L-selenohomocysteine: One-step synthesis from L-selenomethionine and kinetic analysis as substrate for methionine synthases. Bioorganic & Medicinal Chemistry Letters, 10, 2471-2475. PubMed Link

Zhou, Z. H. S., Peariso, K., Penner-Hahn, J. E., & Matthews, R. G. (1999). Identification of the zinc ligands in cobalamin-independent methionine synthase (MetE) from Escherichia coli. Biochemistry, 38, 15915-15926. PubMed Link

Sheppard, C. A., Trimmer, E. E., & Matthews, R. G. (1999). Purification and properties of NADH-dependent 5,10-methylenetetrahydrofolate reductase (MetF) from Escherichia coli. Journal of Bacteriology, 181, 718-725. PubMed Link

Guenther, B. D., Sheppard, C. A., Tran, P., Rozen, R., Matthews, R. G., & Ludwig, M. L. (1999). The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia. Nature Structural Biology, 6, 359-365. PubMed Link

Jarrett, J. T., Huang, S., & Matthews, R. G. (1998). Methionine synthase exists in two distinct conformations that differ in reactivity toward methyltetrahydrofolate, adenosylmethionine, and flavodoxin. Biochemistry, 37, 5372-5382. PubMed Link

Jarrett, J. T., Hoover, D. M., Ludwig, M. L., & Matthews, R. G. (1998). The mechanism of adenosylmethionine-dependent activation of methionine synthase: A rapid kinetic analysis of intermediates in reductive methylation of cob(II)alamin enzyme. Biochemistry, 37, 12649-12658. PubMed Link

Matthews, R. G., Sheppard, C., & Goulding, C. (1998). Methylenetetrahydrofolate reductase and methionine synthase: Biochemistry and molecular biology. European Journal of Pediatrics, 157 (Suppl 2), S54-S59. PubMed Link

Walker, L. A., Jarrett, J. T., Anderson, N. A., Pullen, S. H., Matthews, R. G., & Sension, R. J. (1998). Time-resolved spectroscopic studies of B-12 coenzymes, the identification of a metastable cob(III)alamin photoproduct in the photolysis of methylcobalamin. Journal of the American Chemical Society, 120, 3597-3603.

Peariso, K., Goulding, C. W., Huang, S., Matthews, R. G., & Penner-Hahn, J. E. (1998). Characterization of the zinc binding site in methionine synthase enzymes of Escherichia coli: The role of zinc in the methylation of homocysteine. Journal of the American Chemical Society, 120, 8410-8416. PubMed Link

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Articles (1991-1997)

Hoover, D. M., Jarrett, J. T., Sands, R. H., Dunham, W. R., Ludwig, M. L., & Matthews, R. G. (1997). Interaction of Escherichia coli cobalamin-dependent methionine synthase and its physiological partner flavodoxin: Binding of flavodoxin leads to axial ligand dissociation from the cobalamin cofactor. Biochemistry, 36, 127-138. PubMed Link

Goulding, C. W., Postigo, D., & Matthews, R. G. (1997). Cobalamin-dependent methionine synthase is a modular protein with distinct regions for binding homocysteine, methyltetrahydrofolate, cobalamin, and adenosylmethionine. Biochemistry, 36, 8082-8091. PubMed Link

Jarrett, J. T., Choi, C. Y., & Matthews, R. G. (1997). Changes in protonation associated with substrate binding and cob(I)alamin formation in cobalamin-dependent methionine synthase. Biochemistry, 36, 15739-15748. PubMed Links

Goulding, C. W., & Matthews, R. G. (1997). Cobalamin-dependent methionine synthase from Escherichia coli: Involvement of zinc in homocysteine activation. Biochemistry, 36, 15749-15757. PubMed Link

Matthews, R. G. (1997). Enzyme-catalyzed methyl transfers to thiols: The role of zinc. Current Opinion in Chemical Biology, 1, 332-339. PubMed Link

Bhagwat, S. P., Rice, M. R., Matthews, R. G., & Blumenthal, R. M. (1997). Use of an inducible regulatory protein to identify members of a regulon: Application to the regulon controlled by the leucine-responsive regulatory protein (Lrp) in Escherichia coli. Journal of Bacteriology, 179, 6254-6263. PubMed Link

Wiese, D. E., Ernsting, B. R., Blumenthal, R. M., & Matthews, R. G. (1997). A nucleoprotein activation complex between the leucine-responsive regulatory protein and DNA upstream of the gltBDF operon in Escherichia coli. Journal of Molecular Biology, 270, 152-168. PubMed Link

Amaratunga, M., Fluhr, K., Jarrett, J. T., Drennan, C. L., Ludwig, M. L., Matthews, R. G., & Scholten, J. D. (1996). A synthetic module for the metH gene permits facile mutagenesis of the cobalamin-binding region of Escherichia coli methionine synthase: Initial characterization of seven mutant proteins. Biochemistry, 35, 2453-2463. PubMed Link

Jarrett, J. T., Amaratunga, M., Drennan, C. L., Scholten, J. D., Sands, R. H., Ludwig, M. L., & Matthews, R. G. (1996). Mutations in the B12-binding region of methionine synthase: How the protein controls methylcobalamin reactivity. Biochemistry, 35, 2464-2475. PubMed Link

Gonzalez, J. C., Peariso, K., Penner-Hahn, J. E., & Matthews, R. G. (1996). Cobalamin-independent methionine synthase from Escherichia coli: A zinc metalloenzyme. Biochemistry, 35, 12228-12234. PubMed Link

Jarrett, J. T., Drennan, C. L., Amaratunga, M., Scholten, J. D., Ludwig, M. L., & Matthews, R. G. (1996). Protein radical cage slows photolysis of methylcobalamin in methionine synthase from Escherichia coli. Bioorganic & Medicinal Chemistry, 4, 1237-1246. PubMed Link

Borst, D. W., Blumenthal, R. M., & Matthews, R. G. (1996). Use of an in vivo titration method to study a global regulator: Effect of varying Lrp levels on expression of gltBDF in Escherichia coli. Journal of Bacteriology, 178, 6904-6912. PubMed Link

Drennan, C. L., Matthews, R. G., Rosenblatt, D. S., Ledley, F. D., Fenton, W. A., & Ludwig, M. L. (1996). Molecular basis for dysfunction of some mutant forms of methylmalonyl-CoA mutase: Deductions from the structure of methionine synthase. Proceedings of the National Academy of Sciences of the USA, 93, 5550-5555. PubMed Link

Ludwig, M. L., Drennan, C. L., & Matthews, R. G. (1996). The reactivity of B-12 cofactors: The proteins make a difference. Structure, 4, 505-512. PubMed Link

Dixon, M. M., Huang, S., Matthews, R. G., & Ludwig, M. (1996). The structure of the C-terminal domain of methionine synthase: Presenting S-adenosylmethionine for reductive methylation of B-12. Structure, 4, 1263-1275. PubMed Link

Drummond, J. T., Jarrett, J., Gonzalez, J. C., Huang, S., & Matthews, R. G. (1995). Characterization of nonradioactive assays for cobalamin-dependent and cobalamin-independent methionine synthase enzymes. Analytical Biochemistry, 228, 323-329. PubMed Link

Lipman, R. S. A., Bailey, S. W., Jarrett, J. T., Matthews, R. G., & Jorns, M. S. (1995). Stereospecificity of folate binding to DNA photolyase from Escherichia coli. Biochemistry, 34, 11217-11220. PubMed Link

Eichel, J., Gonzalez, J. C., Hotze, M., Matthews, R. G., & Schroder, J. (1995). Vitamin B-12-independent methionine synthase from a higher plant (Catharanthus roseus) - Molecular characterization, regulation, heterologous expression, and enzyme properties. European Journal of Biochemiistry, 230, 1053-1058. PubMed Link

Ferrario, M., Ernsting, B. R., Borst, D. W., Wiese, D. E., Blumenthal, R. M., & Matthews, R. G. (1995). The leucine-responsive regulatory protein of Escherichia coli negatively regulates transcription of OMPC and MICF and positively regulates translation of OMPF. Journal of Bacteriology, 177, 103-113. PubMed Link

Webb, H. K., & Matthews, R. G. (1995). 4-chlorothreonine is substrate, mechanistic probe, and mechanism-based inactivator of serine hydroxymethyltransferase. Journal of Biological Chemistry, 270, 17204-17209. PubMed Link

Amaratunga, M., Drennan, C. L., Jarrett, J. T., Hoover, D. M., Scholten, J. D., Ludwig, M. L., & Matthews, R. G. (1995). Role of cobalt ligation in the catalytic mechanism of cobalamin-dependent methionine synthase from Escherichia coli. Protein Engineering, 8 (Suppl S), 53.

Drummond, J. T., & Matthews, R. G. (1994). Nitrous oxide degradation by cobalamin-dependent methionine synthase - Characterization of the reactants and products in the inactivation reaction. Biochemistry, 33, 3732-3741. PubMed Link

Drummond, J. T., & Matthews, R. G. (1994). Nitrous oxide inactivation of cobalamin-dependent methionine synthase from Escherichia coli - Characterization of the damage to the enzyme and prosthetic group. Biochemistry, 33, 3742-3750. PubMed Link

Drennan, C. L., Matthews, R. G., & Ludwig, M. L. (1994). Cobalamin-dependent methionine synthase - The structure of a methylcobalamin-binding fragment and implications for other B-12-dependent enzymes. Current Opinion in Structural Biology, 4, 919-929. PubMed Link

Goyette, P., Sumner, J. S., Milos, R., Duncan, A. M. V., Rosenblatt, D. S., Matthews, R. G., & Rozen, R. (1994). Human methylenetetrahydrofolate reductase - Isolation of cDNA, mapping and mutation identification. Nature Genetics, 7, 195-200. PubMed Link

Drennan, C. L., Huang, S., Drummond, J. T., Matthews, R. G., & Ludwig, M. L. (1994). How a protein binds B-12 - A 3.0-angstrom X-ray structure of B-12 binding domains of methionine synthase. Science, 266, 1669-1674. PubMed Link

Bianchi, V., Eliasson, R., Fontecave, M., Mulliez, E., Hoover, D. M., Matthews, R. G., & Reichard, P. (1993). Flavodoxin is required for the activation of the anaerobic ribonucleotide reductase. Biochemical and Biophysical Research Communications, 197, 792-797. PubMed Link

Drummond, J. T., Loo, R. R. O., & Matthews, R. G. (1993). Electrospray mass spectrometric analysis of the domains of a large enzyme - Observation of the occupied cobalamin-binding domain and redefinition of the carboxyl terminus of methionine synthase. Biochemistry, 32, 9282-9289. PubMed Link

Drummond, J. T., Huang, S., Blumenthal, R. M., & Matthews, R. G. (1993). Assignment of enzymatic function to specific protein regions of cobalamin-dependent methionine synthase from Escherichia coli. Biochemistry, 32, 9290-9295. PubMed Link

Ernsting, B. R., Denninger, J. W., Blumenthal, R. M., & Matthews, R. G. (1993). Regulation of the gltBDF operon of Escherichia coli - How is a leucine-insensitive operon regulated by the leucine-responsive regulatory protein. Journal of Bacteriology, 175, 7160-7169. PubMed Link

Gonzalez, J. C., Banerjee, R. V., Huang, S., Sumner, J. S., & Matthews, R. G. (1992). Comparison of cobalamin-independent and cobalamin-dependent methionine synthases from Escherichia coli - Two solutions to the same chemical problem. Biochemistry, 31, 6045-6056. PubMed Link

Ernsting, B. R., Atkinson, M. R., Ninfa, A. J., & Matthews, R. G. (1992). Characterization of the regulon controlled by the leucine-responsive regulatory protein in Escherichia coli. Journal of Bacteriology, 174, 1109-1118. PubMed Link

Lin, R., Ernsting, B., Hirshfield, I. N., Matthews, R. G., Neidhardt, F. C., Clark, R. L., & Newman, E. B. (1992). The Lrp gene product regulates expression of Lysu in Escherichia coli K-12. Journal of Bacteriology, 174, 2779-2784. PubMed Link

Sumner, J. S., & Matthews, R. G. (1992). Stereochemistry and mechanism of hydrogen transfer between NADPH and methylenetetrahydrofolate in the reaction catalyzed by methylenetetrahydrofolate reductase from pig liver. Journal of the American Chemical Society, 114, 6949-6956.

Osborne, C., Chen, L. M., & Matthews, R. G. (1991). Isolation, cloning, mapping, and nucleotide sequencing of the gene encoding flavodoxin in Escherichia coli. Journal of Bacteriology, 173, 1729-1737. PubMed Link

Banerjee, R. V., Harder, S. R., Ragsdale, S. W., & Matthews, R. G. (1990). Mechanism of reductive activation of cobalamin-dependent methionine synthase - An electron paramagnetic resonance spectroelectrochemical study. Biochemistry, 29, 1129-1135. PubMed Link

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Articles (1974-1990)

Banerjee, R. V., Frasca, V., Ballou, D. P., & Matthews, R. G. (1990). Participation of cob(I)alamin in the reaction catalyzed by methionine synthase from Escherichia coli - A steady-state and rapid-reaction kinetic analysis. Biochemistry, 29, 11101-11109.

Rohlman, C. E., & Matthews, R. G. (1990). Role of purine biosynthetic intermediates in response to folate stress in Escherichia coli. Journal of Bacteriology, 172, 7200-7210.

Vanoni, M. A., Lee, S., Floss, H. G., & Matthews, R. G. (1990). Stereochemistry of reduction of methylenetetrahydrofolate to methyltetrahydrofolate catalyzed by pig liver methylenetetrahydrofolate reductase. Journal of the American Chemical Society, 112, 3987-3992.

Matthews, R. G., & Neidhardt, F. C. (1989). Elevated serine catabolism is associated with the heat-shock response in Escherichia coli. Journal of Bacteriology, 171, 2619-2625.

Banerjee, R. V., Johnston, N. L., Sobeski, J. K., Datta, P., & Matthews, R. G. (1989). Cloning and sequence analysis of the Escherichia coli meth gene encoding cobalamin-dependent methionine synthase and isolation of a tryptic fragment containing the cobalamin-binding domain. Journal of Biological Chemistry, 264, 13888-13895.

Green, J. M., Mackenzie, R. E., & Matthews, R. G. (1988). Substrate flux through methylenetetrahydrofolate dehydrogenase - Predicted effects of the concentration of methylenetetrahydrofolate on its partitioning into pathways leading to nucleotide biosynthesis or methionine regeneration. Biochemistry, 27, 8014-8022.

Frasca, V., Banerjee, R. V., Dunham, W. R., Sands, R. H., & Matthews, R. G. (1988). Cobalamin-dependent methionine synthase from Escherichia coli B - Electron paramagnetic resonance spectra of the inactive form and the active methylated form of the enzyme. Biochemistry, 27, 8458-8465.

Matthews, R. G., & Neidhardt, F. C. (1988). Abnormal induction of heat-shock proteins in an Escherichia coli mutant deficient in adenosylmethionine synthetase activity. Journal of Bacteriology, 170, 1582-1588.

Jencks, D. A., & Matthews, R. G. (1987). Alllosteric inhibition of methylenetetrahydrofolate reductase by adenosylmethionine - Effects of adenosylmethionine and NADPH on the equilibrium between active and inactive forms of the enzyme and on the kinetics of approach to equilibrium. Journal of Biological Chemistry, 262, 2485-2493.

Sumner, J., Jencks, D. A., Khani, S., & Matthews, R. G. (1986). Photoaffinity-labeling of methylenetetrahydrofolate reductase with 8-azido-s-adenosylmethionine. Journal of Biological Chemistry, 261, 7697-7700.

Matthews, R. G. (1986). Preparation and analysis of pteroylpolyglutamate substrates and inhibitors. Methods in Enzymology, 122, 333-339.

Matthews, R. G. (1986). Methylenetetrahydrofolate reductase from pig liver. Methods in Enzymology, 122, 372-381.

Ross, J., Green, J., Baugh, C. M., Mackenzie, R. E., & Matthews, R. G. (1984). Studies on the polyglutamate specificity of methylenetetrahydrofolate dehydrogenase from pig liver. Biochemistry, 23, 1796-1801.

Vanoni, M. A., & Matthews, R. G. (1984). Kinetic isotope effects on the oxidation of reduced nicotinamide adenine dinucleotide phosphate by the flavoprotein methylenetetrahydrofolate reductase. Biochemistry, 23, 5272-5279.

Lu, Y. Z., Aiello, P. D., & Matthews, R. G. (1984). Studies on the polyglutamate specificity of thymidylate synthase from fetal pig liver. Biochemistry, 23, 6870-6876.

Vanoni, M. A., Ballou, D. P., & Matthews, R. G. (1983). Methylenetetrahydrofolate reductase - Steady-state and rapid-reaction studies on the NADPH-methylenetetrahydrofolate, NADPH-menadione, and methyltetrahydrofolate-menadione oxidoreductase activities of the enzyme. Journal of Biological Chemistry, 258, 1510-1514.

Matthews, R. G., Ross, J., Baugh, C. M., Cook, J. D., & Davis, L. (1982). Interactions of pig liver serine hydroxymethyltransferase with methyltetrahydropteroylpolyglutamate inhibitors and with tetrahydropteroylpolyglutamate substrates. Biochemistry, 21, 1230-1238.

Matthews, R. G. (1982). Studies on the methylene methyl interconversion catalyzed by methylenetetrahydrofolate reductase from pig liver. Biochemistry, 21, 4165-4171.

Matthews, R. G. (1982). Are the redox properties of tetrahydrofolate cofactors utilized in folate-dependent reactions. Federation Proceedings, 41, 2600-2604.

Daubner, S. C., & Matthews, R. G. (1982). Purification and properties of methylenetetrahydrofolate reductase from pig liver. Journal of Biological Chemistry, 257, 140-145.

Matthews, R. G., & Baugh, C. M. (1980). Interactions of pig liver methylenetetrahydrofolate reductase with methylenetetrahydropteroylpolyglutamate substrates and with dihydropteroylpolyglutamate inhibitors. Biochemistry, 19, 2040-2045.

Thorpe, C., Matthews, R. G., & Williams, C. H. (1979). Acyl-coenzyme A dehydrogenase from pig kidney - Purification and properties. Biochemistry, 18, 331-337.

Matthews, R. G., & Haywood, B. J. (1979). Inhibition of pig liver methylenetetrahydrofolate reductase by dihydrofolate - Some mechanistic and regulatory implications. Biochemistry, 18, 4845-4851.

Matthews, R. G., Ballou, D. P., & Williams, C. H. (1979). Reactions of pig heart lipoamide dehydrogenase with pyridine nucleotides - Evidence for an effector role for bound oxidized pyridine nucleotide. Journal of Biological Chemistry, 254, 4974-4981.

Matthews, R. G., Ballou, D. P., Thorpe, C., & Williams, C. H. (1977). Ion pair formation in pig heart lipoamide dehydrogenase - Rationalization of pH profiles for reactivity of oxidized enzyme with dihydrolipoamide and 2-electron reduced enzyme with lipoamide and iodoacetamide. Journal of Biological Chemistry, 252, 3199-3207.

Matthews, R. G., & Williams, C. H. (1976). Measurement of oxidation-reduction potentials for 2-electron and 4-electron reduction of lipoamide dehydrogenase from pig heart. Journal of Biological Chemistry, 251, 3956-3964.

Matthews, R. G., Massey, V., & Sweeley, C. C. (1975). Identification of para-hydroxybenzaldehyde as ligand in green form of old yellow enzyme. Journal of Biological Chemistry, 250, 9294-9298.

Matthews, R. G., Arscott, L. D., & Williams, C. H. (1974). Isolation, characterization and partial sequencing of cystine and thiol peptides of pig heart lipoamide dehydrogenase. Biochimica et Biophysica Acta, 370, 26-38.

Matthews, R. G., & Williams, C. H. (1974). Identification of thiol residues involved in modifications of pig heart lipoamide dehydrogenase by cupric ion and by iodoacetamide. Biochimica et Biophysica Acta, 370, 39-48.

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Review Articles

Bandarian, V., & Matthews, R. G. (2004). Measurement of energetics of conformational change in cobalamin-dependent methionine synthase. Methods in Enzymology, 380, 152-169.

Ludwig, M. L., & Matthews, R. G. (2002). B-12 dependent methionine synthase: A structure that adapts to catalyze multiple methyl transfer reactions. ACS Symposium Series, 827, 186-201.

Matthews, R. G. (2001). Cobalamin-dependent methyltransferases. Accounts of Chemical Research, 34, 681-689.

Matthews, R. G., Cui, Y. H., Friedberg, D., & Calvo, J. M. (2000). Wild-type and hexahistidine-tagged derivatives of leucine-responsive regulatory protein from Escherichia coli. Methods in Enzymology, 324, 322-329.

Van Bogelen, R. A., Greis, K. D., Blumenthal, R. M., Tani, T. H., & Matthews, R. G. (1999). Mapping regulatory networks in microbial cells. Trends in Microbiology, 7, 320-328.

Matthews, R. G., Drummond, J. T., & Webb, H. K. (1998). Cobalamin-dependent methionine synthase and serine hydroxymethyltransferase: Targets for chemotherapeutic intervention? Advances in Enzyme Regulation, 38, 377-392.

Ludwig, M. L., & Matthews, R. G. (1997). Structure-based perspectives on B-12 dependent enzymes. Annual Review of Biochemistry, 66, 269-313.

Jarrett, J. T., Goulding, C. W., Fluhr, K., Huang, S., & Matthews, R. G. (1997). Purification and assay of cobalamin-dependent methionine synthase from Escherichia coli. Methods in Enzymology, 281, 196-213.

Blumenthal, R. M., Borst, D. W., & Matthews, R. G. (1996). Experimental analysis of global gene regulation in Escherichia coli. Progress in Nucleic Acid Research and Molecular Biology, 55, 1-86.

Calvo, J. M., & Matthews, R. G. (1995). The leucine-responsive regulatory protein, a global regulator of metabolism in Escherichia coli. Microbiological Reviews, 58, 466-490. [Correction 59, 323].

Matthews, R. G., & Drummond, J. T. (1990). Providing one-carbon units for biological methylations - Mechanistic studies on serine hydroxymethyltransferase, methylenetetrahydrofolate reductase, and methyltetrahydrofolate-homocysteine methyltransferase. Chemical Reviews, 90, 1275-1290.

Banerjee, R. V., & Matthews, R. G. (1990). Cobalamin-dependent methionine synthase. FASEB Journal, 4, 1450-1459.

Matthews, R. G., Ghose, C., Green, J. M., Matthews, K. D., & Dunlap, R. B. (1987). Folylpolyglutamates as substrates and inhibitors of folate-dependent enzymes. Advances in Enzyme Regulation, 26, 157-171.

Matthews, R. G., Ross, J., Baugh, C. M., Cook, J. D., & Davis, L. (1983). The role of folylpolyglutamates in the regulation of folate metabolism. Advances in Experimental Medicine and Biology, 163, 35-44.

Matthews, R. G., & Daubner, S. C. (1982). Modulation of methylenetetrahydrofolate reductase activity by s-adenosylmethionine and by dihydrofolate and its polyglutamate analogs. Advances in Enzyme Regulation, 20, 123-131.

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Editorial Material

Matthews, R. G., & Walsh, C. T. (2005). Mechanisms - The logic of biological process - Editorial overview. Current Opinion in Chemical Biology, 9, 421-423.

Dijkstra, B. W., & Matthews, R. G. (2003). Catalysis and regulation - From structure to function - Editorial review. Current Opinion in Structural Biology, 13, 706-708.

Ludwig, M. L., & Matthews, R. G. (2002). Effector regulation in a monomeric enzyme. Nature Structural Biology, 9, 236-238.

Matthews, R. G., & Djikstra, B. W. (2001). Catalysis and regulation - Movies, metals, bonds and barriers - Editorial overview. Current Opinion in Structural Biology, 11, 655-656.

Matthews, R. G. (1982). Mini-symposium presented at the 72nd annual meeting of the American Society for Biological Chemists, St. Louis, Missouri, June 2, 1981 - Biochemical roles of pterins and folates - Introduction. Federation Proceedings, 41, 2599.

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Letters

Matthews, R. G. (1999). Regulatory network analysis - Response. Trends in Microbiology, 7, 399.

Frosst, P., Blom, H. J., Milos, R., Goyette, P., Sheppard, C. A., Matthews, R. G., Boers, G. J. H., Denheijer, M., Kluijtmans, L. A. J., Vandenheuvel, L. P., & Rozen, R. (1995). A candidate genetic risk factor for vascular disease - A common mutation in methylenetetrahydrofolate reductase. Nature Genetics, 10, 111-113.

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Notes

Luschinsky, C. L., Drummond, J. T., Matthews, R. G., & Ludwig, M. L. (1992). Crystallization and preliminary X-ray diffraction studies of the cobalamin-binding domain of methionine synthase from Escherichia coli. Journal of Molecular Biology, 225, 557-560.

Green, J. M., Ballou, D. P., & Matthews, R. G. (1988). Examination of the role of methylenetetrahydrofolate reductase in incorporation of methyltetrahydrofolate into cellular metabolism. FASEB Journal, 2, 42-47.

Frasca, V., Riazzi, B. S., & Matthews, R. G. (1986). In vitro inactivation of methionine synthase by nitrous oxide. Journal of Biological Chemistry, 261, 5823-5826.

Zydowsky, T. M., Courtney, L. F., Frasca, V., Kobayashi, K., Shimizu, H., Yuen, L. D., Matthews, R. G., Benkovic, S. J., & Floss, H. G. (1986). Stereochemical analysis of the methyl transfer catalyzed by cobalamin-dependent methionine synthase from Escherichia coli B. Journal of the American Chemical Society, 108, 3152-3153.

Klinman, J. P., & Matthews, R. G. (1985). Calculation of substrate dissociation constants from steady-state isotope effects in enzyme-catalyzed reactions. Journal of the American Chemical Society, 107, 1058-1060.

Matthews, R. G., Vanoni, M. A., Hainfeld, J. F., & Wall, J. (1984). Methylenetetrahydrofolate reductase - Evidence for spatially distinct subunit domains obtained by scanning transmission electron microscopy and limited proteolysis. Journal of Biological Chemistry, 259, 1647-1650.

Matthews, R. G., & Kaufman, S. (1980). Characterization of the dihydropterin reductase activity of pig liver methylenetetrahydrofolate reductase. Journal of Biological Chemistry, 255, 6014-6017.

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