Cobalamin-dependent methionine synthase consists of four functional modules arranged in a linear fashion. To complete catalysis, the protein must coordinate large domain movements, which allow the central cobalamin-binding unit to interact with distinct active sites ≈50 Å apart!

Focusing primarily on vitamin B12 and folic acid, Matthews’ investigates the role vitamins play in complex chemical reactions that can lead to heart disease and development of neural tube defects in the fetus.