Publications

Recent Articles | Articles (2000-2004) | Articles (1994-1999) | Articles (1988-1993) | Review Articles | Notes/Additions

Recent Articles

Inoki, K., Ouyang, H., Zhu, T., Lindvall, C., Wang, Y., Yang, Q., Bennett, C., Harada, Y., Stankunas, K., Wang, C., He, H., MacDougald, O., You, M., Williams, B., and Guan, K-L. (2006). TSC2 integrates Wnt and cellular energy signals through a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126, 955-68.

Yang Q., Inoki K., Ikenoue T., & Guan, K. L. (2006). Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev, 20, 2820-32.

Aurandt, J., Li, W. Q., & Guan, K. L. (2006). Semaphorin 4D activates the MAPK pathway downstream of plexin-B1. Biochemical Journal, 394, 459-464.

Chong-Kopera, H., Inoki, K., Li, Y., Zhu, T. Q., Garcia-Gonzalo, F. R., Rosa, J. L., & Guan, K. L. (2006). TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. Journal of Biological Chemistry, 281, 8313-8316.

Li, W. Q., Aurandt, J., Jurgense, C., Rao, Y., & Guan, K. L. (2006). FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5. Journal of Cell Science, 119, 47-55.

Yang, Q., Inoki, K., Kim, E., & Guan, K. L. (2006). TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Proceedings of the National Academy of Sciences of the USA, 103, 6811-6816.

Corradetti, M. N., Inoki, K., & Guan, K. L. (2005). The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. Journal of Biological Chemistry, 280, 9769-9772.

Yu, Y. D., Li, S., Xu, X., Li, Y., Guan, K. L., Arnold, E., & Ding, J. P. (2005). Structural basis for the unique biological function of small GTPase RHEB. Journal of Biological Chemistry, 280, 17093-17100.

Gan, B. Y., Melkoumian, Z. K., Wu, X. Y., Guan, K. L., & Guan, J. L. (2005). Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control. Journal of Cell Biology, 170, 379-389.

Wolf, M. T. F., Lee, J., Panther, F., Otto, E. A., Guan, K. L., & Hildebrandt, F. (2005). Expression and phenotype analysis of the nephrocystin-1 and nephrocystin-4 homologs in Caenorhabditis elegans. Journal of the American Society of Nephrology, 16, 676-687.

Lee, J., Li, W. Q., & Guan, K. L. (2005). SRC-1 mediates unc-5 signaling in Caenorhabditis elegans. Molecular and Cellular Biology, 25, 6485-6495.

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Articles (2000-2004)

Wang, M., Devereux, T. R., Vikis, H. G., McCulloch, S. D., Holliday, W., Anna, C., Wang, Y., Bebenek, K., Kunkel, T. A., Guan, K. L., & You, M. (2004). Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia. Cancer Research, 64, 1924-1931.

Basile, J. R., Barac, A., Zhu, T. Q., Guan, K. L., & Gutkind, J. S. (2004). Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B. Cancer Research, 64, 5212-5224.

Yoder, J. H., Chong, H. R., Guan, K. L., & Han, M. (2004). Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase. EMBO Journal, 23, 111-119.

Ruan, Q., Wang, Q., Me, S. Q., Fang, Y. Q., Darzynkiewicz, Z., Guan, K. L., Jhanwar-Uniyal, M., & Dai, W. (2004). Polo-like kinase 3 is Golgi localized and involved in regulating Golgi fragmentation during the cell cycle. Experimental Cell Research, 294, 51-59.

Corradetti, M. N., Inoki, K., Bardeesy, N., DePinho, R. A., & Guan, K. L. (2004). Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes & Development, 18, 1533-1538.

Li, W. Q., & Guan, K. L. (2004). The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak. Journal of Biological Chemistry, 279, 32824-32831.

Li, W. Q., Zhu, T. Q., & Guan, K. L. (2004). Transformation potential of Ras Isoforms correlates with activation of phosphatidylinositol 3-kinase but not ERK. Journal of Biological Chemistry, 279, 37398-37406.

Yang, F., Yamashita, J., Tang, E., Wang, H. L., Guan, K. L., & Wang, C. Y. (2004). The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and TNF-mediated NF-kappa B activation through inhibiting phosphorylation of the I-kappa B kinase beta activation loop. Journal of Immunology, 172, 2446-2452.

Kruger, R. P., Lee, J., Li, W. Q., & Guan, K. L. (2004). Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation. Journal of Neuroscience, 24, 10826-10834.

Li, Y., Inoki, K., & Guan, K. L. (2004). Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. Molecular and Cellular Biology, 24, 7965-7975.

Li, W. Q., Lee, J., Vikis, H. G., Lee, S. H., Liu, G. F., Aurandt, J., Shen, T. L., Fearon, E. R., Guan, J. L., Han, M., Rao, Y., Hong, K. S., & Guan, K. L. (2004). Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nature Neuroscience, 7, 1213-1221.

Xie, S. Q., Wang, Q., Ruan, Q., Liu, T. Y., Jhanwar-Uniyal, M., Guan, K. L., & Dai, W. (2004). MEK1-induced Golgi dynamics during cell cycle progression is partly mediated by Polo-like kinase-3. Oncogene, 23, 3822-3829.

Hurley, J. H., Zhang, S. W., Bye, L. S., Marshall, M. S., DePaoli-Roach, A. A., Guan, K. L., Fox, A. P., & Yu, L. (2003). Insulin signaling inhibits the 5-HT2C receptor in choroid plexus via MAP kinase. BMC Neuroscience, 4, 10.

Inoki, K., Zhu, T. Q., & Guan, K. L. (2003). TSC2 mediates cellular energy response to control cell growth and survival. Cell, 115, 577-590.

Lanigan, T. M., Liu, A., Huang, Y. Z., Mei, L., Margolis, B., & Guan, K. L. (2003). Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. FASEB Journal, 17, 2048-2060.

Inoki, K., Li, Y., Xu, T., & Guan, K. L. (2003). Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes & Development, 17, 1829-1834.

Li, Y., Inoki, K., Vacratsis, P., & Guan, K. L. (2003). The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. Journal of Biological Chemistry, 278, 13663-13671.

Chong, H. R., & Guan, K. L. (2003). Regulation of Raf through phosphorylation and N terminus-C terminus interaction. Journal of Biological Chemistry, 278, 36269-36276.

Tang, E. D., Wang, C. Y., Xiong, Y., & Guan, K. L. (2003). A role for NF-kappa B essential modifier/I kappa B kinase-gamma (NEMO/IKK gamma) ubiquitination in the activation of the I kappa B kinase complex by tumor necrosis factor-alpha. Journal of Biological Chemistry, 278, 37297-37305.

Tang, E. D., Inohara, N., Wang, C. Y., Nunez, G., & Guan, K. L. (2003). Roles for homotypic interactions and transautophosphorylation in I kappa B kinase (IKK beta) activation. Journal of Biological Chemistry, 278, 38566-38570. [Correction: 278, 49661]

Yang, F., Tang, E., Guan, K. L., & Wang, C. Y. (2003). IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide. Journal of Immunology, 170, 5630-5635.

Zhang, Z. Q., Futamura, M., Vikis, H. G., Wang, M., Li, H., Wang, Y., Guan, K. L., & You, M. (2003). Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice. Proceedings of the National Academy of Sciences of the USA, 100, 12642-12647.

Zhou, Q. M., Rammohan, K., Lin, S. L., Robinson, N., Li, O., Liu, X. L., Bai, X. F., Yin, L. J., Scarberry, B., Du, P. S., You, M., Guan, K. L., Zheng, P., & Liu, Y. (2003). CD24 is a genetic modifier for risk and progression of multiple sclerosis. Proceedings of the National Academy of Sciences of the USA, 100, 15041-15046. [Correction: 102, 8392]

Vikis, H. G., Li, W. Q., & Guan, K. L. (2002). The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. Genes & Development, 16, 836-845.

Li, Y., Inoki, K., Yeung, R., & Guan, K. L. (2002). Regulation of TSC2 by 14-3-3 binding. Journal of Biological Chemistry, 277, 44593-44596.

You, Z. B., Saims, D., Chen, S. Q., Zhang, Z. C., Guttridge, D. C., Guan, K. L., MacDougald, O. A., Brown, A. M. C., Evan, G., Kitajewski, J., & Wang, C. Y. (2002). Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. Journal of Cell Biology, 157, 429-440.

Inoki, K., Li, Y., Zhu, T. Q., Wu, J., & Guan, K. L. (2002). TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling. Nature Cell Biology, 4, 648-657.

Vikis, H. G., Stewart, S., & Guan, K. L. (2002). SmgGDS displays differential binding and exchange activity towards different Ras isoforms. Oncogene, 21, 2425-2432.

Aurandt, J., Vikis, H. G., Gutkind, J. S., Ahn, N., & Guan, K. L. (2002). The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. Proceedings of the National Academy of Sciences of the USA, 99, 12085-12090.

Tan, M. J., Bian, J. H., Guan, K. L., & Sun, Y. (2001). p53CP is p51/p63, the third member of the p53 gene family: partial purification and characterization. Carcinogenesis, 22, 295-300.

Chong, H., Lee, J., & Guan, K. L. (2001). Positive and negative regulation of Raf kinase activity and function by phosphorylation. EMBO Journal, 20, 3716-3727.

Zhang, B. H., & Guan, K. L. (2001). Regulation of the Raf kinase by phosphorylation. Experimental Lung Research, 27, 269-295.

Lu, C. R., Li, Y., Zhao, Y. L., Xing, G. C., Tang, F., Wang, Q. M., Sun, Y. H., Wei, H. D., Yang, X. M., Wu, C. S., Chen, J. G., Guan, K. L., Zhang, C. G., Chen, H. P., & He, F. C. (2001). Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway. FASEB Journal 15, U221-U238.

Zhang, B. H., Tang, E. D., Zhu, T. Q., Greenberg, M. E., Vojtek, A. B., & Guan, K. L. (2001). Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf. Journal of Biological Chemistry, 276, 31620-31626.

Li, W. Q., Chong, H. R., & Guan, K. L. (2001). Function of the Rho family GTPases in Ras-stimulated Raf activation. Journal of Biological Chemistry, 276, 34728-34737.

Chen, S. Q., Guttridge, D. C., Tang, E., Shi, S. T., Guan, K. L., & Wang, C. Y. (2001). Suppression of tumor necrosis factor-mediated apoptosis by nuclear factor kappa B-independent bone morphogenetic protein/Smad signaling. Journal of Biological Chemistry, 276, 39259-39263.

Zhang, Z. Q., Wang, Y., Vikis, H. G., Johnson, L., Liu, G. J., Li, J., Anderson, M. W., Sills, R. C., Hong, H. L., Devereux, T. R., Jacks, T., Guan, K. L., & You, M. (2001). Wild-type Kras2 can inhibit lung carcinogenesis in mice. Nature Genetics, 29, 25-33.

Koga, M., Zwaal, R., Guan, K. L., Avery, L., & Ohshima, Y. (2000). A Caenorhabditis elegans MAP kinase kinase, MEK-1, is involved in stress responses. EMBO Journal, 19, 5148-5156.

Zhang, B. H., & Guan, K. L. (2000). Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601. EMBO Journal, 19, 5429-5439.

Li, W. Q., Han, M., & Guan, K. L. (2000). The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf. Genes & Development, 14, 895-900.

Xiao, G. Z., Jiang, D., Thomas, P., Benson, M. D., Guan, K. L., Karsenty, G., Franceschi, R. T. (2000). MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1. Journal of Biological Chemistry, 275, 4453-4459.

Stewart, S., & Guan, K. L. (2000). The dominant negative Ras mutant, N17Ras, can inhibit signaling independently of blocking Ras activation. Journal of Biological Chemistry, 275, 8854-8862.

Guan, K. L., Figueroa, C., Brtva, T. R., Zhu, T. Q., Taylor, J., Barber, T. D., & Vojtek, A. B. (2000). Negative regulation of the serine/threonine kinase B-Raf by Akt. Journal of Biological Chemistry, 275, 27354-27359.

Li, Y., Li, M., Xing, G. C., Hu, Z. Y., Wang, Q. M., Dong, C. N., Wei, H. D., Fan, G. C., Chen, J. Z., Yang, X. M., Zhao, S. F., Chen, H. P., Guan, K. L., Wu, C. S., Zhang, C. G., & He, F. C. (2000). Stimulation of the mitogen-activated protein kinase cascade and tyrosine phosphorylation of the epidermal growth factor receptor by hepatopoietin. Journal of Biological Chemistry, 275, 37443-37447.

Zhan, X. L., Hong, Y. L., Zhu, T. Q., Mitchell, A. P., Deschenes, R. J., & Guan, K. L. (2000). Essential functions of protein tyrosine phosphatases PTP2 and PTP3 and RIM11 tyrosine phosphorylation in Saccharomyces cerevisiae meiosis and sporulation. Molecular Biology of the Cell, 11, 663-676.

Tan, M. J., Wang, Y. X., Guan, K. L., & Sun, Y. (2000). PTCF-beta, a type beta transforming growth factor (TGF-beta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway. Proceedings of the National Academy of Sciences of the USA, 97, 109-114.

Vikis, H. G., Li, W. Q., He, Z. G., & Guan, K. L. (2000). The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner. Proceedings of the National Academy of Sciences of the USA, 97, 12457-12462.

Simon, A. R., Vikis, H. G., Fanburg, B. L., Stewart, S., Fanburg, B. L., Cochran, B. H., & Guan, K. L. (2000). Regulation of STAT3 by direct binding to the Rac1 GTPase. Science, 290, 144-147.

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Articles (1994-1999)

Noh, S. J., Li, Y., Xiong, Y., & Guan, K. L. (1999). Identification of functional elements of p18(INK4C) essential for binding and inhibition of cyclin-dependent kinase (CDK)4 and CDK6. Cancer Research, 59, 558-564.

Tan, M. J., Heizmann, C. W., Guan, K. L., Schafer, B. W., & Sun, Y. (1999). Transcriptional activation of the human S100A2 promoter by wild-type p53. FEBS Letters, 445, 265-268.

Guan, K. L., & Han, M. (1999). A G-protein signaling network mediated by an RGS protein. Genes & Development, 13, 1763-1767.

Zhan, X. L., & Guan, K. L. (1999). A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase. Genes & Development, 13, 2811-2827.

Tan, M. J., Li, S. J., Swaroop, M. J., Guan, K. L., Oberley, L.W., & Sun, Y. (1999). Transcriptional activation of the human glutathione peroxidase promoter by p53. Journal of Biological Chemistry, 274, 12061-12066.

Tang, E. D., Nunez, G., Barr, F. G., & Guan, K. L. (1999). Negative regulation of the forkhead transcription factor FKHR by Akt. Journal of Biological Chemistry, 274, 16741-16746.

Stewart, S., Sundaram, M., Zhang, Y. P., Lee, J. Y., Han, M., & Guan, K. L. (1999). Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. Molecular and Cellular Biology, 19, 5523-5534.

Herzog, C. R., Noh, S., Lantry, L. E., Guan, K. L., & You, M. (1999). Cdkn2a encodes functional variation of p16(INK4a) but not p19(ARF), which confers selection in mouse lung tumorigenesis. Molecular Carcinogenesis, 25, 92-98.

Sugimoto, T., Stewart, S., Han, M., & Guan, K. L. (1998). The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation. EMBO Journal, 17, 1717-1727.

Zhao, Y., Wu, L., Noh, S. J., Guan, K. L., & Zhang, Z. Y. (1998). Altering the nucleophile specificity of a protein-tyrosine phosphatase-catalyzed reaction - Probing the function of the invariant glutamine residues. Journal of Biological Chemistry, 273, 5484-5492.

Hodge, C., Liao, J. F., Stofega, M., Guan, K. L., Carter-Su, C., & Schwartz, J. (1998). Growth hormone stimulates phosphorylation and activation of Elk-1 and expression of c-fos, egr-1, and junB through activation of extracellular signal-regulated kinases 1 and 2. Journal of Biological Chemistry, 273, 31327-31336.

Dabrowski, A., Groblewski, G. E., Schaefer, C., Guan, K. L., & Williams, J.A. (1997). Cholecystokinin and EGF activate a MAPK cascade by different mechanisms in rat pancreatic acinar cells. American Journal of Physiology, 273, C1472-1479.

Vanderkuur, J. A., Butch, E. R., Waters, S. B., Pessin, J. E., Guan, K. L., & Carter-Su, C. (1997). Signaling molecules involved in coupling growth hormone receptor to mitrogen-activated protein kinase activation. Endocrinology, 138, 4301-4307.

Zhan, X. L., Deschenes, R. J., & Guan, K. L. (1997). Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiae. Genes & Development, 11, 1690-1702.

Tang, D. G., Guan, K. L., Li, L., Honn, K. V., Chen, Y. Q., Rice, R. L., Taylor, J. D., & Porter, A. T. (1997). Suppression of W256 carcinosarcoma cell apoptosis by arachidonic acid and other polyunsaturated fatty acids. International Journal of Cancer, 72, 1078-1087.

Jiang, Y., Li, Z. J., Schwarz, E. M., Lin, A. N., Guan, K. L., Ulevitch, R. J., & Han, J. H. (1997). Structure-function studies of p38 mitogen-activated protein kinase - Loop 12 influences substrate specificity and autophosphorylation, but not upstream kinase selection. Journal of Biological Chemistry, 272, 11096-11102.

Sugimoto, T., Stewart, S., & Guan, K. L. (1997). The calcium/calmodulin-dependent protein phosphatase calcineurin is the major Elk-1 phosphatase. Journal of Biological Chemistry, 272, 29415-29418.

Syu, L. J., Guan, K. L., & Saltiel, A. R. (1997). Inducible expression of a mutant form of MEK1 in Swiss 3T3 cells. Journal of Cellular Biochemistry, 67, 367-377.

Gorgas, G., Butch, E. R., Guan, K. L., & Miller, R. A. (1997). Diminished activation of the MAP kinase pathway in CD3-stimulated T lymphocytes from old mice. Mechanisms of Ageing and Development, 94, 71-83.

Gupta, A. K., Lee, Y. J., Galoforo, S. S., Berns, C. M., Martinez, A. A., Corry, P. M., Wu, X. Y., & Guan, K. L. (1997). Differential effect of glucose deprivation on MAPK activation in drug sensitive human breast carcinoma MCF-7 and multidrug resistant MCF-7/ADR cells. Molecular and Cellular Biochemistry, 170, 23-30.

Sugimoto, T., Haneda, M., Togawa, M., Isono, M., Shikano, T., Araki, S., Nakagawa, T., Kashiwagi, A., Guan, K. L., & Kikkawa, R. (1996). Atrial natriuretic peptide induces the expression of MKP-1, a mitogen-activated protein kinase phosphatase, in glomerular mesangial cells. Journal of Biological Chemistry, 271, 544-547.

Wu, X. Y., Noh, S. J., Zhou, G. C., Dixon, J. E., & Guan, K. L. (1996). Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells. Journal of Biological Chemistry, 271, 3265-3271.

Butch, E. R., & Guan, K. L. (1996). Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2. Journal of Biological Chemistry, 271, 4230-4235.

Robinson, M. J., Cheng, M., Khokhlatchev, A., Ebert, D., Ahn, N., Guan, K. L., Stein, B., Goldsmith, E., & Cobb, M. H. (1996). Contributions of the mitogen-activated protein (MAP) kinase backbone and phosphorylation loop to MEK specificity. Journal of Biological Chemistry, 271, 29734-29739.

Guan, K. L., Jenkins, C. W., Li, Y., O'Keefe, C. L., Noh, S., Wu, X. Y., Zariwala, M., Matera, A. G., & Xiong, Y. (1996). Isolation and characterization of p19(INK4d), a p16-related inhibitor specific to CDK6 and CDK4. Molecular Biology of the Cell, 7, 57-70.

Duan, R. D., Zheng, C. F., Guan, K. L., & Williams, J. A. (1995). Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat pancreatic acini. American Journal of Physiology, 268, G1060-1065.

Pang, L., Zheng, C. F., Guan, K. L., & Saltiel, A. R. (1995). Nerve growth factor stimulates a novel protein kinase in PC-12 cells that phosphorylates and activates mitogen-activated protein kinase kinase (MEK). Biochemical Journal, 307, 513-519.

Zhang, Z. Y., Zhou, G. C., Denu, J. M., Wu, L., Tang, X. J., Mondesert, O., Russell, P., Butch, E., & Guan, K. L. (1995). Purification and characterization of the low molecular weight protein tyrosine phosphatase, Stp1, from the fission yeast Schizosaccharomyces pombe. Biochemistry 34, 10560-10568.

Church, D. L., Guan, K. L., & Lambie, E. J. (1995). 3 genes of the MAP kinase cascade, MEK-2, MPK-1/SUR-1 and LET-60 Ras, are required for meiotic cell cycle progression in Caenorhabditis elegans. Development, 121, 2525-2535.

Wu, Y., Han, M., & Guan, K. L. (1995). MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulvar induction and other developmental events. Genes & Development, 9, 742-755.

Kornfeld, K., Guan, K. L., & Horvitz, H. R. (1995). The Caenorhabditis elegans gene MEK-2 is required for vulvar induction and encodes a protein similar to the protein kinase MEK. Genes & Development, 9, 756-768.

Guan, K. L., & Butch, E. (1995). Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen activated protein kinase. Journal of Biological Chemistry, 270, 7197-7203.

Wang, Q. M., Guan, K. L., Roach, P. J., & Depaoli-Roach, A. A. (1995). Phosphorylation and activation of the ATP-Mg dependent protein phosphatase by the mitogen activated protein kinase. Journal of Biological Chemistry, 270, 18352-18358.

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Articles (1988-1993)

Zheng, C. F., Ohmichi, M., Saltiel, A. R., & Guan, K. L. (1994). Growth factor induced MEK activation is primarily mediated by an activator different from c-raf. Biochemistry, 33, 5595-5599.

Zheng, C. F., & Guan, K. L. (1994). Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues. EMBO Journal, 13, 1123-1131.

Guan, K. L., Jenkins, C. W., Li, Y., Nichols, M. A., Wu, X. Y., O'keefe, C. L., Matera, A. G., & Xiong, Y. (1994). Growth suppression by p18, a p16(INK4/MTS1)-related and p14(INK4B/MTS2)-related CDK6 inhibitor, correlates with wild type pRb function. Genes & Development, 8, 2939-2952.

Zheng, C. F., & Guan, K. L. (1994). Cytoplasmic localization of the mitogen-activated protein kinase activator MEK. Journal of Biological Chemistry, 269, 19947-19952.

Frost, J. A., Alberts, A. S., Sontag, E., Guan, K. L., Mumby, M. C., & Feramisco, J. R. (1994). Simian virus 40 small T antigen cooperates with mitogen-activated kinases to stimulate AP-1 activity. Molecular and Cellular Biology, 14, 6244-6252.

Guan, K. L., Farh, L., Marshall, T. K., & Deschenes, R. J. (1993). Normal mitochondrial structure and genome maintenance in yeast requires the dynamin-like product of the MGM1 gene. Current Genetics, 24, 141-148.

Zheng, C. F., & Guan, K. L. (1993). Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. Journal of Biological Chemistry, 268, 11435-11439.

Zheng, C. F., & Guan, K. L. (1993). Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases. Journal of Biological Chemistry, 268, 23933-23939.

Millar, J. B. A., Russell, P., Dixon, J. E., & Guan, K. L. (1992). Negative regulation of mitosis by two functionally overlapping PT-pases in fission yeast. EMBO Journal, 11, 4943-4952.

Guan, K. L., Deschenes, R. J., & Dixon, J. E. (1992). Isolation and characterization of a second protein tyrosine phosphatase gene, PTP2, from Saccharomyces cerevisiae. Journal of Biological Chemistry, 267, 10024-10030.

Guan, K. L., & Dixon, J. E. (1991). Eukaryotic proteins expressed in Escherichia coli - An improved thrombin cleavage and purification procedure of fusion proteins with glutathione-s-transferase. Analytical Biochemistry, 192, 262-267.

Ni, L. Y., Guan, K. L., Zalkin, H., & Dixon, J. E. (1991). De novo purine nucleotide biosynthesis - Cloning, sequencing and expression of a chicken purH cDNA encoding 5-aminoimidazole-4-carboxamide ribonucleotide transformylase IMP cyclohydrolase. Gene, 106, 197-205.

Guan, K. L., & Dixon, J. E. (1991). Evidence for protein tyrosine phosphatase catalysis proceeding via a cysteine phosphate intermediate. Journal of Biological Chemistry, 266, 17026-17030.

Guan, K. L., Broyles, S. S., & Dixon, J. E. (1991). A tyr ser protein phosphatase encoded by vaccinia virus. Nature, 350, 359-362.

Bliska, J. B., Guan, K. L., Dixon, J. E., & Falkow, S. (1991). Tyrosine phosphate hydrolysis of host proteins by an essential Yersinia virulence determinant. Proceedings of the National Academy of Sciences of the USA, 88, 1187-1191.

Guan, K. L., Haun, R. S., Watson, S. J., Geahlen, R. L., & Dixon, J. E. (1990). Cloning and expression of a protein-tyrosine-phosphatase. Proceedings of the National Academy of Sciences of the USA, 87, 1501-1505.

Guan, K. L., & Dixon, J. E. (1990). Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia. Science, 249, 553-556.

Farres, J., Guan, K. L., & Weiner, H. (1989). Primary structures of rat and bovine liver mitochondrial aldehyde dehydrogenases deduced from cDNA sequences. European Journal of Biochemistry, 180, 67-74.

Guan, K. L., & Weiner, H. (1989). Influence of the 5'-end region of aldehyde dehydrogenase messenger RNA on translational efficiency - Potential secondary structure inhibition of translation in vitro. Journal of Biological Chemistry, 264, 17764-17769.

Guan, K. L., Pak, Y. K., Tu, G. C., Qing, N. C., & Weiner, H. (1988). Purification and characterization of beef and pig liver aldehyde dehydrogenases. Alcoholism - Clinical and Experimental Research, 12, 713-719.

Farres, J., Guan, K. L., & Weiner, H. (1988). Sequencee of the signal peptide for rat liver mitochondrial aldehyde dehydrogenase. Biochemical and Biophysical Research Communications, 150, 1083-1087.

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Review Articles

Corradetti M. N. & Guan, K. L. (2006). Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?. Oncogene, 25, 6347-60.

Li, Y., Inoki, K., Vikis, H., & Guan, K. L. (2006). Measurements of TSC2 GAP activity toward PDLEB. Methods in Enzymology, 407, 46-54.

Inoki, K., & Guan, K. L. (2006). Complexity of the TOR signaling network. Trends in Cell Biology, 16, 206-212.

Inoki, K., Ouyang, H., Li, Y., & Guan, K. L. (2005). Signaling by target of rapamycin proteins in cell growth control. Microbiology and Molecular Biology Reviews, 69, 79-100.

Inoki, K., Corradetti, M. N., & Guan, K. L. (2005). Dysregulation of the TSC-mTOR pathway in human disease. Nature Genetics, 37, 19-24.

Kruger, R. R., Aurandt, J., & Guan, K. L. (2005). Semaphorins command cells to move. Nature Reviews Molecular Cell Biology, 6, 789-800.

Li, Y., Corradetti, M. N., Inoki, K., & Guan, K. L. (2004). TSC2: Filling the GAP in the mTOR signaling pathway. Trends in Biochemical Sciences, 29, 32-38.

Chong, H., Vikis, H. G., & Guan, K. L. (2003). Mechanisms of regulating the Raf kinase family. Cellular Signalling, 15, 463-469.

Guan, K. L., & Rao, Y. (2003). Signalling mechanisms mediating neuronal responses to guidance cues. Nature Reviews Neuroscience, 4, 941-956.

Zhan, X. L., Wishart, M. J., & Guan, K. L. (2001). Nonreceptor tyrosine phosphatases in cellular signaling: Regulation of mitogen-activated protein kinases. Chemical Reviews, 101, 2477-2496.

Guan, K. L. (1994). The mitogen-activated protein kinase signal transduction pathway - From the cell surface to the nucleus. Cellular Signalling, 6, 581-589.

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Notes/Additions

Waters, S. B., Holt, K. H., Ross, S. E., Syu, L. J., Guan, K. L., Saltiel, A. R., Koretzky, G. A., & Pessin, J. E. (1995). Desensitization of Ras activation by a feedback disassociation of the SOS-GRB2 complex. Journal of Biological Chemistry, 270, 20883-20886.

Pham, C. D., Arlinghaus, R. B., Zheng, C. F., Guan, K. L., & Singh, B. (1995). Characterization of MEK1 phosphorylation by the V-Mos protein. Oncogene, 10, 1683-1688.

Zheng, C. F., & Guan, K. L. (1993). Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced thr tyr protein phosphatase. Journal of Biological Chemistry, 268, 16116-16119.

Guan, K. L., Hakes, D. J., Wang, Y., Park, H. D., & Cooper, T. G. (1993). A yeast protein phosphatase related to the vaccinia virus VH1 phosphatase is induced by nitrogen starvation. [Addition]. Proceedings of the National Academy of Sciences of the USA, 90, 1137.

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