Ginsburg Lab
Publications
Recent Articles | Articles (2000-2004) | Articles (1990-1999) | Articles (1985-1989) | Editorial Material | Notes
Recent Articles
Tan, F.L., & Ginsburg, D. What a polyclonal antibody sees in von Willebrand factor. Thrombosis Research (in press). PubMed Link
Zhu, A., Sun, H., Raymond, R.M., Furie, B.C., Bronstein, M., Kaufman, R.J., Westrick, R., & Ginsburg, D. (2007). Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase. Blood 109, 5270-5. PubMed Link
Lemmerhirt, H.L., Broman, K.W., Shavit, J.A., & Ginsburg, D. (2007). Genetic regulation of plasma von Willebrand factor levels: quantitative trait loci analysis in a mouse model. J Thromb Haemost 5, 329-35. PubMed Link
Seligsohn, U., & Ginsburg, D. (2006). Deciphering the mystery of combined factor V and factor VIII deficiency. J Thromb Haemost 4, 927-31. PubMed Link
Nyfeler, B., Zhang, B., Ginsburg, D., Kaufman, R.J., & Hauri, H.P. (2006). Cargo selectivity of the ERGIC-53/MCFD2 transport receptor complex. Traffic 7, 473-81. PubMed Link
Zhang, B., McGee, B., Yamaoka, J. S., Guglielmone, H., Downes, K. A., Minoldo, S., Jarchum, G., Peyvandi, F., de Bosch, N. B., Ruiz-Saez, A., Chatelain, B., Olpinski, M., Bockenstedt, P., Sperl, W., Kaufman, R. J., Nichols, W. C., Tuddenham, E. G. D., & Ginsburg, D. (2006). Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2. Blood, 107, 1903-1907. PubMed Link
Lemmerhirt, H.L., Shavit, J.A., Levy, G.G., Cole, S.M., Long, J.C., and Ginsburg, D. (2006). Enhanced VWF biosynthesis and elevated plasma VWF due to a natural variant in the murine Vwf gene. Blood 108, 3061-7. PubMed Link
Cole, J.N., McArthur, J.D., McKay, F.C., Sanderson-Smith, M.L., Cork, A.J., Ranson, M., Rohde, M., Itzek, A., Sun, H., Ginsburg, D., Kotb, M., Nizet, V., Chhatwal, G.S., and Walker, M.J. (2006). Trigger for group A streptococcal M1T1 invasive disease. FASEB J. 20, 1745-7. PubMed Link
Crawford, G. E., Holt, I. E., Whittle, J., Webb, B. D., Tai, D., Davis, S., Margulies, E. H., Chen, Y. D., Bernat, J. A., Ginsburg, D., Zhou, D. X., Luo, S. J., Vasicek, T. J., Daly, M. J., Wolfsberg, T. G., & Collins, F. S. (2006). Genome-wide mapping of DNase hypersensitive sites using massively parallel signature sequencing (MPSS). Genome Research, 16, 123-131. PubMed Link
Bernat, J. A., Crawford, G. E., Ogurtsov, A. Y., Collins, F. S., Ginsburg, D., & Kondrashov, A. S. (2006). Distant conserved sequences flanking endothelial-specific promoters contain tissue-specific DNase-hypersensitive sites and over-represented motifs. Human Molecular Genetics, 15, 2098-2105. PubMed Link
Chauhan, A. K., Motto, D. G., Lamb, C. B., Bergmeier, W., Dockal, M., Plaimauer, B., Scheiflinger, F., Ginsburg, D., & Wagner, D. D. (2006). Systemic antithrombotic effects of ADAMTS13. Journal of Experimental Medicine, 203, 767-776. PubMed Link
Seligsohn, U., & Ginsburg, D. (2006). Deciphering the mystery of combined factor V and factor VIII deficiency. Journal of Thrombosis and Haemostasis, 4, 927-931. PubMed Link
Eitzman, D. T., Westrick, R. J., Shen, Y. C., Bodary, P. F., Gu, S. F., Manning, S. L., Dobies, S. L., & Ginsburg, D. (2005). Homozygosity for factor V Leiden leads to enhanced thrombosis and atherosclerosis in mice. Circulation, 111, 1822-1825. PubMed Link
Sirachainan, N., Zhang, B., Chuansumrit, A., Pipe, S., Sasanakul, W., & Ginsburg, D. (2005). Combined factor V and factor VIII deficiency in a Thai patient: A case report of genotype and phenotype characteristics. Haemophilia, 11, 280-284. PubMed Link
Zhou, W. H., Dong, L. L., Ginsburg, D., Bouhassira, E. E., & Tsai, H. M. (2005). Enzymatically active ADAMTS13 variants are not inhibited by anti-ADAMTS13 autoantibodies - A novel therapeutic strategy? Journal of Biological Chemistry, 280, 39934-39941. PubMed Link
Motto, D. G., Chauhan, A. K., Zhu, G. J., Homeister, J., Lamb, C. B., Desch, K. C., Zhang, W. R., Tsai, H. M., Wagner, D. D., & Ginsburg, D. (2005). Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice. Journal of Clinical Investigation, 115, 2752-2761. PubMed Link
Ginsburg, D. (2005). Identifying novel genetic determinants of hemostatic balance. Journal of Thrombosis and Haemostasis, 3, 1561-1568. PubMed Link
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Articles (2000-2004)
Segal, A., Zivelin, A., Rosenberg, N., Ginsburg, D., Shpilberg, O., & Seligsohn, U. (2004). A mutation in LMAN1 (ERGIC-53) causing combined factor V and factor VIII deficiency is prevalent in Jews originating from the island of Djerba in Tunisia. Blood Coagulation & Fibrinolysis, 15, 99-102. PubMed Link
Sun, H. M., Ringdahl, U., Homeister, J. W., Fay, W. P., Engleberg, N. C., Yang, A. Y., Rozek, L. S., Wang, X. X., Sjobring, U., & Ginsburg, D. (2004). Plasminogen is a critical host pathogenicity factor for group A streptococcal infection. Science, 305, 1283-1286. PubMed Link
Sun, H. M., Yang, T. L., Yang, A., Wang, X. X., & Ginsburg, D. (2003). The murine platelet and plasma factor V pools are biosynthetically distinct and sufficient for minimal hemostasis. Blood, 102, 2856-2861. PubMed Link
Savasan, S., Lee, S. K., Ginsburg, D., & Tsai, H. M. (2003). ADAMTS13 gene mutation in congenital thrombotic thrombocytopenic purpura with previously reported normal VWF cleaving protease activity. Blood, 101, 4449-4451. PubMed Link
Cunningham, M. A., Pipe, S. W., Zhang, B., Hauri, H. P., Ginsburg, D., & Kaufman, R. J. (2003). LMAN1 is a molecular chaperone for the secretion of coagulation factor VIII. Journal of Thrombosis and Haemostasis, 1, 2360-2367. PubMed Link
Becker, D. J., Myers, J. T., Ruff, M. M., Smith, P. L., Gillespie, B. W., Ginsburg, D., & Lowe, J. B. (2003). Strain-specific modification of lethality in fucose-deficient mice. Mammalian Genome, 14, 130-139. PubMed Link
Zhang, B., Cunningham, M. A., Nichols, W. C., Bernat, J. A., Seligsohn, U., Pipe, S. W., McVey, J. H., Schulte-Overberg, U., de Bosch, N. B., Ruiz-Saez, A., White, G. C., Tuddenham, E. G. D., Kaufman, R. J., Ginsburg, D. (2003). Bleeding due to disruption of a cargo-specific ER to Golgi transport complex. Nature Genetics, 34, 220-225. PubMed Link
Eitzman, D. T., Westrick, R. J., Bi, X. M., Manning, S. L., Wilkinson, J. E., Broze, G. J., & Ginsburg, D. (2002). Lethal perinatal thrombosis in mice resulting from the interaction of tissue factor pathway inhibitor deficiency and factor V Leiden. Circulation, 105, 2139-2142. PubMed Link
Ellies, L. G., Ditto, D., Levy, G. G., Wahrenbrock, M., Ginsburg, D., Varki, A., Le, D. T., & Marth, J. D. (2002). Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands. Proceedings of the National Academy of Sciences of the USA, 99, 10042-10047. PubMed Link
McMahon, G. A., Petitclerc, E., Stefansson, S., Smith, E., Wong, M. K. K., Westrick, R. J., Ginsburg, D., Brooks, P. C., & Lawrence, D. A. (2001). Plasminogen activator inhibitor-1 regulates tumor growth and angiogenesis. Journal of Biological Chemistry, 276, 33964-33968. PubMed Link
Levy, G. G., Nichols, W. C., Lian, E. C., Foroud, T., McClintick, J. N., McGee, B. M., Yang, A. Y., Siemieniak, D. R., Stark, K. R., Gruppo, R., Sarode, R., Shurin, S. B., Chandrasekaran, V., Stabler, S. P., Sabio, H., Bouhassira, E. E., Upshaw, J. D., Ginsburg, D., Tsai, H. M. (2001). Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Nature, 413, 488-494. PubMed Link
Goodeve, A. C., Eikenboom, J. C. J., Ginsburg, D., Hilbert, L., Mazurier, C., Peake, I. R., Sadler, J. E., & Rodeghiero, F. (2001). A standard nomenclature for von Willebrand factor gene mutations and polymorphisms. Thrombosis and Haemostasis, 85, 929-931. PubMed Link
Levy, G., & Ginsburg, D. (2001). Getting at the variable expressivity of von Willebrand disease. Thrombosis and Haemostasis, 86, 144-148. PubMed Link
Sjöland, H., Eitzman, D. T., Gordon, D., Westrick, R., Nabel, E. G., & Ginsburg, D. (2000). Atherosclerosis progression in LDL receptor-deficient and apolipoprotein E-deficient mice is independent of genetic alterations in plasminogen activator inhibitor-1. Arteriosclerosis, Thrombosis and Vascular Biology, 20, 846-852. PubMed Link
Eitzman, D. T., Westrick, R. J., Xu, Z. J., Tyson, J., & Ginsburg, D. (2000). Hyperlipidemia promotes thrombosis following injury to atherosclerotic vessels in apolipoprotein E-deficient mice. Arteriosclerosis, Thrombosis and Vascular Biology, 20, 1831-1834. PubMed Link
Eitzman, D. T., Westrick, R. J., Nabel, E. G., & Ginsburg, D. (2000). Plasminogen activator inhibitor-1 and vitronectin promote vascular thrombosis in mice. Blood, 95, 577-580. PubMed Link
Cui, J. S., Eitzman, D. T., Westrick, R. J., Christie, P. D., Xu, Z. J. J., Yang, A. Y., Purkayastha, A. A., Yang, T. L., Metz, A. L., Gallagher, K. P., Tyson, J. A., Rosenberg, R. D., & Ginsburg, D. (2000). Spontaneous thrombosis in mice carrying the factor V Leiden mutation. Blood, 96, 4222-4226. PubMed Link
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Articles (1990-1999)
Mohlke, K. L., Purkayastha, A. A., Westrick, R. J., Smith, P. L., Petryniak, B., Lowe, J. B., Ginsburg, D. (1999). Mvwf, a dominant modifier of von Willebrand factor, results from altered lineage-specific expression of a glycosyltransferase. Cell, 96, 111-120. PubMed Link
Ginsburg, D. (1999). The molecular biology of von Willebrand disease. Haemophilia, 5 (Suppl 2), 19-27.
Moussalli, M., Pipe, S. W., Hauri, H. P., Nichols, W. C., Ginsburg, D., & Kaufman, R. J. (1999). Mannose-dependent endoplasmic reticulum (ER)-Golgi intermediate compartment-53-mediated ER to Golgi trafficking of coagulation factors V and VIII. Journal of Biological Chemistry, 274, 32539-32542. PubMed Link
Dougherty, K. M., Pearson, J. M., Yang, A. Y., Westrick, R. J., Baker, M. S., & Ginsburg, D. (1999). The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival. Proceedings of the National Academy of Sciences of the USA, 96, 686-691. PubMed Link
Sharp, A. M., Stein, P. E., Pannu, N. S., Carrell, R. W., Berkenpas, M. B., Ginsburg, D., Lawrence, D. A., & Read, R. J. (1999). The active conformation of plasminogen activator inhibitor-1, a target for drugs to control fibrinolysis and cell adhesion. Structure, 7, 111-118. PubMed Link
Ginsburg, D. (1999). Molecular genetics of von Willebrand disease. Thrombosis and Haemostasis, 82, 585-591. PubMed Link
Yang, T. L., Cui, J. S., Rehumtulla, A., Yang, A., Moussalli, M., Kaufman, R. J., & Ginsburg, D. (1998). The structure and function of murine factor V and its inactivation by protein C. Blood, 91, 4593-4599. PubMed Link
Nichols, W. C., Seligsohn, U., Zivelin, A., Terry, V. H., Hertel, C. E., Wheatley, M. A., Moussalli, M. J., Hauri, H. P., Ciavarella, N., Kaufman, R. J., & Ginsburg, D. (1998). Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII. Cell, 93, 61-70. PubMed Link
Mohlke, K. L., Purkayastha, A. A., Westrick, R. J., & Ginsburg, D. (1998). Comparative mapping of distal murine chromosome 11 and human 17q21.3 in a region containing a modifying locus for murine plasma von Willebrand factor level. Genomics, 54, 19-30. PubMed Link
Ginsburg, D., Nichols, W. C., Zivelin, A., Kaufman, R. J., & Seligsohn, U. (1998). Combined factors V and VIII deficiency - the solution. Haemophilia, 4, 677-682. PubMed Link
Risse, B. C., Brown, H., Lavker, R. M., Pearson, J. M., Baker, M. S., Ginsburg, D., & Jensen, P. J. (1998). Differentiating cells of murine stratified squamous epithelia constitutively express plasminogen activator inhibitor type 2 (PAI-2). Histochemistry and Cell Biology, 110, 559-569. PubMed Link
Lavker, R. M., Risse, B., Brown, H., Ginsburg, D., Pearson, J., Baker, M. S., & Jensen, P. J. (1998). Localization of plasminogen activator inhibitor type 2 (PAI-2) in hair and nail: Implications for terminal differentiation. Journal of Investigative Dermatology, 110, 917-922. PubMed Link
Eitzman, D. T., & Ginsburg, D. (1997). Of mice and men - The function of plasminogen activator inhibitors (PAIs) in vivo. Advances in Experimental Medicine and Biology, 425, 131-141. PubMed Link
Tsai, H. M., Sussman, I. I., Ginsburg, D., Lankhof, H., Sixma, J. J., & Nagel, R. L. (1997). Proteolytic cleavage of recombinant type 2A von Willebrand factor mutants R834W and R834Q: Inhibition by doxycycline and by monoclonal antibody VP-1. Blood, 89, 1954-1962. PubMed Link
Lawrence, D. A., Palaniappan, S., Stefansson, S., Olson, S. T., Francis-Chmura, A. M., Shore, J. D., & Ginsburg, D. (1997). Characterization of the binding of different conformational forms of plasminogen activator inhibitor-1 to vitronectin - Implications for the regulation of pericellular proteolysis. Journal of Biological Chemistry, 272, 7676-7680. PubMed Link
Nichols, W. C., Seligsohn, U., Zivelin, A., Terry, V. H., Arnold, N. D., Siemieniak, D. R., Kaufman, R. J., & Ginsburg D. (1997). Linkage of combined factors V and VIII deficiency to chromosome 18q by homozygosity mapping. Journal of Clinical Investigation, 99, 596-601. PubMed Link
Nichols, W. C., Koller, D., Slovis, B., Foroud, T., Terry, V. H., Arnold, N. D., Siemieniak, D. R., Wheeler, L., Phillips, J. A., Newman, J. H., Conneally, P. M., Ginsburg, D., Loyd, J. E. (1997). Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32. Nature Genetics, 15, 277-280. PubMed Links
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Articles (1990-1996)
Cooney, K. A., & Ginsburg, D. (1996). Comparative analysis of type 2b von Willebrand disease mutations: Implications for the mechanism of von Willebrand factor binding to platelets. Blood, 87, 2322-2328. PubMed Link
Eitzman, D. T., Krauss, J. C., Shen, T. L., Cui, J. S., & Ginsburg, D. (1996). Lack of plasminogen activator inhibitor-1 effect in a transgenic mouse model of metastatic melanoma. Blood, 87, 4718-4722. PubMed Link
Nichols, W. C., Amano, K., Cacheris, P. M., Figueiredo, M. S., Michaelides, K., Schwaab, R., Hoyer, L., Kaufman, R. J., & Ginsburg, D. (1996). Moderation of hemophilia A phenotype by the Factor V R506Q mutation. Blood, 88, 1183-1187. PubMed Link
Nichols, W. C., Antin, J. H., Lunetta, K. L., Terry, V. H., Hertel, C. E., Wheatley, M. A., Arnold, N. D., Siemieniak, D. R., Boehnke, M., & Ginsburg, D. (1996). Polymorphism of adhesion molecule CD31 is not a significant risk factor for graft-versus-host disease. Blood, 88, 4429-4434. PubMed Link
Mohlke, K. L., Nichols, W. C., Rehemtulla, A., Kaufman, R. J., Fagerstrom, H. M., Ritvanen, K. L. A., Kekomaki, R., & Ginsburg, D. (1996). A common frameshift mutation in von Willebrand factor does not alter mRNA stability but interferes with normal propeptide processing. British Journal of Haematology, 95, 184-191. PubMed Link
Eitzman, D. T., McCoy, R. D., Zheng, X. X., Fay, W. P., Shen, T. L., Ginsburg, D., & Simon, R. H. (1996). Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. Journal of Clinical Investigation, 97, 232-237. PubMed Link
Pipe, S. W., Schmaier, A. H., Nichols, W. C., Ginsburg, D., Bozynski, M. E. A., & Castle, V. P. (1996). Neonatal purpura fulminans in association with factor V R506Q mutation. Journal of Pediatrics, 128, 706-709. PubMed Link
Cui, J. S., O'Shea, K. S., Purkayastha, A., Saunders, T. L., & Ginsburg, D. (1996). Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V. Nature, 384, 66-68. PubMed Link
Mohlke, K. L., Nichols, W. C., Westrick, R. J., Novak, E. K., Cooney, K. A., Swank, R. T., & Ginsburg, D. (1996). A novel modifier gene for plasma von Willebrand factor level maps to distal mouse chromosome 11. Proceedings of the National Academy of Sciences of the USA , 93, 15352-15357. PubMed Link
Berkenpas, M. B., Lawrence, D. A., & Ginsburg, D. (1995). Molecular evolution of plasminogen activator inhibitor-1 functional stability. EMBO Journal, 14, 2969-2977. PubMed Link
Shore, J. D., Day, D. E., Francis-Chmura, A. M., Verhamme, I., Kvassman, J., Lawrence, D. A., & Ginsburg, D. (1995). A fluorescent probe study of plasminogen activator inhibitor-1 - Evidence for reactive center loop insertion and its role in the inhibitory mechanism. Journal of Biological Chemistry, 270, 5395-5398. PubMed Link
Sherman, P. M., Lawrence, D. A., Verhamme, I. M., Paielli, D., Shore, J. D., & Ginsburg, D. (1995). Identification of tissue-type plasminogen activator-specific plasminogen activator inhibitor-1 mutants - Evidence that second sites of interaction contribute to target specificity. Journal of Biological Chemistry, 270, 9301-9306. PubMed Link
Olson, S. T., Bock, P. E., Kvassman, J., Shore, J. D., Lawrence, D. A., Ginsburg, D., Björk, I. (1995). Role of the catalytic serine in the interactions of serine proteinases with protein inhibitors of the serpin family - Contribution of a covalent interaction to the binding energy of serpin-proteinase complexes. Journal of Biological Chemistry, 270, 30007-30017. PubMed Link
Zheng, X. X., Saunders, T. L., Camper, S. A., Samuelson, L. C., & Ginsburg, D. (1995). Vitronectin is not essential for normal mammalian development and fertility. Proceedings of the National Academy of Sciences of the USA, 92, 12426-12430.
Lawrence, D. A., Olson, S. T., Palaniappan, S., & Ginsburg, D. (1994). Engineering plasminogen activator inhibitor-1 mutants with increased functional stability. Biochemistry, 33, 3643-3648. PubMed Link
Fay, W. P., Eitzman, D. T., Shapiro, A. D., Madison, E. L., & Ginsburg, D. (1994). Platelets inhibit fibrinolysis in vitro by both plasminogen activator inhibitor-1 dependent and inhibitor-1 independent mechanisms. Blood, 83, 351-356. PubMed Link
Lyons, S. E., Cooney, K. A., Bockenstedt, P., & Ginsburg, D. (1994). Characterization of Leu777Pro and Ile865Thr type IIA von Willebrand disease mutations. Blood, 83, 1551-1557. PubMed Link
Nichols, W. C., Cooney, K. A., Mohlke, K. L., Ballew, J. D., Yang, A., Bruck, M. E., Reddington, M., Novak, E. K., Swank, R. T., & Ginsburg, D. (1994). von Willebrand disease in the RIIIS/J mouse is caused by a defect outside of the von Willebrand factor gene. Blood, 83, 3225-3231. PubMed Link
Lawrence, D. A., Berkenpas, M. B., Palaniappan, S., & Ginsburg, D. (1994). Localization of the vitronectin binding domain in plasminogen activator inhibitor-1. Journal of Biological Chemistry, 269, 15223-15228. PubMed Link
Lawrence, D. A., Olson, S. T., Palaniappan, S., & Ginsburg, D. (1994). Serpin reactive center loop mobility is required for inhibitor but not for enzyme recognition. Journal of Biological Chemistry, 269, 27657-27662. PubMed Link
Piétu, G., Ribba, A. S., Chérel, G., Siguret, V., Obert, B., Rouault, C., Ginsburg, D., & Meyer, D. (1994). Epitope mapping of inhibitory monoclonal antibodies to human von Willebrand factor by using recombinant cDNA libraries. Thrombosis and Haemostasis, 71, 788-792. PubMed Link
Lyons, S. E., & Ginsburg, D. (1994). Molecular and cellular biology of von Willebrand factor. Trends in Cardiovascular Medicine, 4, 34-39.
Naski, M. C., Lawrence, D. A., Mosher, D. F., Podor, T. J., & Ginsburg, D. (1993). Kinetics of inactivation of alpha-thrombin by plasminogen activator inhibitor-1 - Comparison of the effects of native and urea-treated forms of vitronectin. Journal of Biological Chemistry, 268, 12367-12372. PubMed Link
Ginsburg, D., & Sadler, J. E. (1993). von Willebrand disease - A database of point mutations, insertions, and deletions. Thrombosis and Haemostasis, 69, 177-184. PubMed Link
Sadler, J. E., & Ginsburg, D. (1993). A database of polymorphisms in the von Willebrand factor gene and pseudogene. Thrombosis and Haemostasis, 69, 185-191. PubMed Link
Roth, M. S., Antin, J. H., Ash, R., Terry, V. H., Gotlieb, M., Silver, S. M., & Ginsburg, D. (1992). Prognostic significance of Philadelphia chromosome-positive cells detected by the polymerase chain reaction after allogeneic bone marrow transplant for chronic myelogenous leukemia. Blood, 79, 276-282. PubMed Link
Ginsburg, D. (1992). Biology of inherited coagulopathies - von Willebrand factor. Hematology/Oncology Clinics of North America, 6, 1011-1020. PubMed Link
Lyons, S. E., Bruck, M. E., Bowie, E. J. W., & Ginsburg, D. (1992). Impaired intracellular transport produced by a subset of type IIA von Willebrand disease mutations. Journal of Biological Chemistry, 267, 4424-4430. PubMed Link
Sherman, P. M., Lawrence, D. A., Yang, A. Y., Vandenberg, E. T., Paielli, D., Olson, S. T., Shore, J. D., & Ginsburg, D. (1992). Saturation mutagenesis of the plasminogen activator inhibitor-1 reactive center. Journal of Biological Chemistry, 267, 7588-7595. PubMed Link
Cooney, K. A., Lyons, S. E., & Ginsburg, D. (1992). Functional analysis of a type IIB von Willebrand disease missense mutation - Increased binding of large von Willebrand factor multimers to platelets. Proceedings of the National Academy of Sciences of the USA, 89, 2869-2872. PubMed Link
Ginsburg, D., Bockenstedt, P. L., Allen, E. A., Fox, D. A., Foster, P. A., Ruggeri, Z. M., Zimmerman, T. S., Montgomery, R. R., Bahou, W. F., Johnson, T. A., & Yang, A. Y. (1992). Fine mapping of monoclonal antibody epitopes on human von Willebrand factor using a recombinant peptide library. Thrombosis and Haemostasis, 67, 166-171. PubMed Link
Iannuzzi, M. C., Hidaka, N., Boehnke, M., Bruck, M. E., Hanna, W. T., Collins, F. S., & Ginsburg, D. (1991). Analysis of the relationship of von Willebrand disease (vWD) and hereditary hemorrhagic telangiectasia and identification of a potential type-IIA vWD mutation (IIe865 to Thr). American Journal of Human Genetics, 48, 757-763. PubMed Link
Cooney, K. A., Nichols, W. C., Bruck, M. E., Bahou, W. F., Shapiro, A. D., Bowie, E. J. W., Gralnick, H. R., & Ginsburg, D. (1991). The molecular defect in type-IIB von Willebrand disease - Identification of four potential missense mutations within the putative Gplb binding domain. Journal of Clinical Investigation, 87, 1227-1233. PubMed Link
Ginsburg, D. (1991). The von Willebrand factor gene and genetics of von Willebrand disease. Mayo Clinic Proceedings, 66, 506-15. PubMed Link
Chottiner, E. G., Shewach, D. S., Datta, N. S., Ashcraft, E., Gribbin, D., Ginsburg, D., Fox, I. H., & Mitchell, B. S. (1991). Cloning and expression of human deoxycytidine kinase cDNA. Proceedings of the National Academy of Sciences of the USA, 88, 1531-1535. PubMed Link
Nichols, W. C., Lyons, S. E., Harrison, J. S., Cody, R. L., & Ginsburg, D. (1991). Severe von Willebrand disease due to a defect at the level of von Willebrand factor mRNA expression: Detection by exonic PCR-restriction fragment length polymorphism analysis. Proceedings of the National Academy of Sciences of the USA, 88, 3857-3861. PubMed Link
Sieving, P. A., Bingham, E. L., Roth, M. S., Young, M. R., Boehnke, M., Kuo, C. Y., & Ginsburg, D. (1990). Linkage relationship of X-linked juvenile retinoschisis with Xp22.1-p22.3 probes. American Journal of Human Genetics, 47, 616-621. PubMed Link
Engelke, D. R., Krikos, A., Bruck, M. E., & Ginsburg, D. (1990). Purification of thermus aquaticus DNA polymerase expressed in Escherichia coli. Analytical Biochemistry, 191, 396-400.
Roth, M. S., Weiner, G. J., Allen, E. A., Terry, V. H., Harnden, C. E., Boehnke, M., Kaminski, M. S., & Ginsburg, D. (1990). Molecular characterization of anti-idiotype antibody-resistant variants of a murine B cell lymphoma. Journal of Immunology, 145, 768-777. PubMed Link
Roth, M. S., Antin, J. H., Bingham, E. L., & Ginsburg, D. (1990). Use of polymerase chain reaction-detected sequence polymorphisms to document engraftment following allogeneic bone marrow transplantation. Transplantation, 49, 714-720. PubMed Link
Articles (1985-1989)
Chottiner, E. G., Ginsburg, D., Tartaglia, A. P., & Mitchell, B. S. (1989). Erythrocyte adenosine-deaminase overproduction in hereditary hemolytic anemia. Blood, 74, 448-453. PubMed Link
Roth, M. S., Antin, J. H., Bingham, E. L., & Ginsburg, D. (1989). Detection of Philadelphia chromosome-positive cells by the polymerase chain reaction following bone marrow transplant for chronic myelogenous leukemia. Blood, 74, 882-885. PubMed Link
Follo, M., & Ginsburg, D. (1989). Structure and expression of the human gene encoding plasminogen activator inhibitor, PAI-1. Gene, 84, 447-453. PubMed Link
Bahou, W. F., Ginsburg, D., Sikkink, R., Litwiller, R., & Fass, D. N. (1989). A monoclonal antibody to von Willebrand factor (VWF) inhibits factor VIII binding - Localization of its antigenic determinant to a nonadecapeptide at the amino terminus of mature VWF polypeptide. Journal of Clinical Investigation, 84, 56-61. PubMed Link
Ginsburg, D., Konkle, B. A., Gill, J. C., Montgomery, R. R., Bockenstedt, P. L., Johnson, T. A., & Yang, A. Y. (1989). Molecular basis of human von Willebrand disease - Analysis of platelet von Willebrand factor messenger RNA. Proceedings of the National Academy of Sciences of the USA, 86, 3723-3727. PubMed Link
Roth, M. S., Schnitzer, B., Bingham, E. L., Harnden, C. E., Hyder, D. M., & Ginsburg, D. (1988). Rearrangement of immunoglobulin and T-cell receptor genes in Hodgkin's disease. American Journal of Pathology, 131, 331-338. PubMed Link
Bahou, W. F., Bowie, E. J. W., Fass, D. N., & Ginsburg, D. (1988). Molecular genetic analysis of porcine von Willebrand disease - Tight linkage to the von Willebrand factor locus. Blood, 72, 308-313. PubMed Link
Schnitzer, B., Roth, M. S., Hyder, D. M., & Ginsburg, D. (1988). Ki-1 lymphomas in children. Cancer, 61, 1213-1221. PubMed Link
Konkle, B. A., & Ginsburg, D. (1988). The addition of endothelial cell growth factor and heparin to human umbilical vein endothelial cell cultures decreases plasminogen activator inhibitor-1 expression. Journal of Clinical Investigation, 82, 579-585. PubMed Link
Headington, J. T., Roth, M. S., Ginsburg, D., Lichter, A. S., Hyder, D., & Schnitzer, B. (1987). T-cell receptor gene rearrangement in regressing atypical histiocytosis. Archives of Dermatology, 123, 1183-1187. PubMed Link
Goldberg, M. A., Ginsburg, D., Mayer, R. J., Stone, R. M., Maguire, M., Rosenthal, D. S., & Antin, J. H. (1987). Is heparin administration necessary during induction chemotherapy for patients with acute promyelocytic leukemia? Blood, 69, 187-191. PubMed Link
Iannuzzi, M. C., Konkle, B. A., Ginsburg, D., & Collins, F. S. (1987). RsaI RFLP in the human von Willebrand factor gene. Nucleic Acids Research, 15, 5909. PubMed Link
Ginsburg, D., Zeheb, R., Yang, A. Y., Rafferty, U. M., Andreasen, P. A., Nielsen, L., Dano, K., Lebo, R. V., & Gelehrter, T. D. (1986). cDNA cloning of human plasminogen activator-inhibitor from endothelial cells. Journal of Clinical Investigation, 78, 1673-1680. PubMed Link
Bonthron, D. T., Handin, R. I., Kaufman, R. J., Wasley, L. C., Orr, E. C., Mitsock, L. M., Ewenstein, B., Loscalzo, J., Ginsburg, D., & Orkin, S. H. (1986). Structure of pre-pro-von Willebrand factor and its expression in heterologous cells. Nature, 324, 270-273. PubMed Link
Bonthron, D., Orr, E. C., Mitsock, L. M., Ginsburg, D., Handin, R. I., & Orkin, S. H. (1986). Nucleotide sequence of pre-pro-von Willebrand factor cDNA. Nucleic Acids Research, 14, 7125-7127. PubMed Link
Fay, P. J., Kawai, Y., Wagner, D. D., Ginsburg, D., Bonthron, D., Ohlsson-Wilhelm, B. M., Chavin, S. I., Abraham, G. N., Handin, R. I., Orkin, S. H., Montgomery, R. R., & Marder, V. J. (1986). Propolypeptide of von Willebrand factor circulates in blood and is identical to von Willebrand antigen II. Science, 232, 995-998. PubMed Link
Antin, J. H., Ginsburg, D., Smith, B. R., Nathan, D. G., Orkin, S. H., & Rappeport, J. M. (1985). Bone marrow transplantation for paroxysmal nocturnal hemoglobinuria - Eradication of the PNH clone and documentation of complete lymphohematopoietic engraftment. Blood, 66, 1247-1250. PubMed Link
Ginsburg, D., Antin, J. H., Smith, B. R., Orkin, S. H., & Rappeport, J. M. (1985). Origin of cell populations after bone marrow transplantation - Analysis using DNA sequence polymorphisms. Journal of Clinical Investigation, 75, 596-603. PubMed Link
Ault, K. A., Antin, J. H., Ginsburg, D., Orkin, S. H., Rappeport, J. M., Keohan, M. L., Martin, P., & Smith, B. R. (1985). Phenotype of recovering lymphoid cell populations after marrow transplantation. Journal of Experimental Medicine, 161, 1483-1502. PubMed Link
Collins, T., Ginsburg, D., Boss, J. M., Orkin, S. H., & Pober, J. S. (1985). Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis. Nature, 316, 748-750. PubMed Link
Ginsburg, D., Handin, R. I., Bonthron, D. T., Donlon, T. A., Bruns, G. A. P., Latt, S. A., & Orkin, S. H. (1985). Human von Willebrand factor (VWF) - Isolation of complementary DNA (cDNA) clones and chromosomal localization. Science, 228, 1401-1406. PubMed Link
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Review Articles
Levy, G. G., Motto, D. G., & Ginsburg, D. (2005). ADAMTS13 turns 3. Blood, 106, 11-17.
Zhang, B., & Ginsburg, D. (2004). Familial multiple coagulation factor deficiencies: New biologic insight from rare genetic bleeding disorders. Journal of Thrombosis and Haemostasis, 2, 1564-1572.
Mohlke, K. L., Nichols, W. C., & Ginsburg, D. (1999). The molecular basis of von Willebrand disease. International Journal of Clinical & Laboratory Research, 29, 1-7.
Mohlke, K. L., & Ginsburg, D. (1997). von Willebrand disease and quantitative variation in von Willebrand factor. Journal of Laboratory and Clinical Medicine, 130, 252-261.
Nichols, W. C., & Ginsburg, D. (1997). von Willebrand disease. Medicine, 76, 1-20.
Ginsburg, D., & Bowie, E. J. W. (1992). Molecular genetics of von Willebrand disease. Blood, 79, 2507-2519.
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Editorial Material
Zhang, B., & Ginsburg, D. (2003). Getting secretory granules ready for prime time. Cell, 115, 372-373.
Ginsburg, D. (2002). The history and evolution of the ASCI: deja vu all over again. Journal of Clinical Investigation, 110, S1-S4.
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Notes
Lawrence, D. A., Ginsburg, D., Day. D. E., Berkenpas, M. B., Verhamme, I. M., Kvassman, J. O., & Shore, J. D. (1995). Serpin-protease complexes are trapped as stable acyl-enzyme intermediates. Journal of Biological Chemistry, 270, 25309-25312.
Eitzman, D. T., Fay, W. P., Lawrence, D. A., Francis-Chmura, A. M., Shore, J. D., Olson, S. T., & Ginsburg, D. (1995). Peptide-mediated inactivation of recombinant and platelet plasminogen activator inhibitor-1 in vitro. Journal of Clinical Investigation, 95, 2416-2420.
Barrow, L. L., Simin, K., Mohlke, K., Nichols, W. C., Ginsburg, D., & Meisler, M. H. (1993). Conserved linkage of neurotrophin-3 and von Willebrand factor on mouse chromosome 6. Mammalian Genome, 4, 343-345.
Fay, W. P., Shapiro, A. D., Shih, J. L., Schleef, R. R., Ginsburg, D. (1992). Brief report - Complete deficiency of plasminogen activator inhibitor type-1 due to a frameshift mutation. New England Journal of Medicine, 327, 1729-1733.
Cacheris, P. M., Nichols, W. C., & Ginsburg, D. (1991). Molecular characterization of a unique von Willebrand disease variant - A novel mutation affecting von Willebrand factor factor VIII interaction. Journal of Biological Chemistry, 266, 13499-13502.
Gribbin, T., Chottiner, E., Ginsburg, D., & Mitchell, B. (1989). Identification of an APA-I polymorphism within the human adenosine deaminase (ADA) gene. Nucleic Acids Research, 17, 3626.
Roth, M. S., Collins, F. S., & Ginsburg, D. (1988). Sizing of the human T-cell receptor alpha-locus and detection of a large deletion in the Molt-4 cell line. Blood, 71, 1744-1747.
Konkle, B. A., Kim, S., Iannuzzi, M. C., Alani, R., Collins, F. S., & Ginsburg, D. (1987). Saci RFLP in the human von Willebrand factor gene. Nucleic Acids Research, 15, 6766.
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