Currents@LSI

LSI Lab Happenings

Arrivals

Carroll Lab:

Young Ho Seo from Iowa State University, background in total synthesis from George Kraus's lab.

Lin Lab:

Carlos Hernandez

from University of Valencia in Spain. He is studying mechanisms that regulate energy homeostasis.

Hu Lab:

Yongsoon Kim is a new postdoc originally from Korea from Dr. Hong Sun's lab at Yale, where he did his first postdoc.

Departures

David Buchner, PhD, postdoctoral fellow, Case Western Reserve University

David Motto, MD, PhD, Assistant Professor, Department of Internal Medicine, University of Iowa

Awards

David Ginsburg received the 2006 Cotlove Award from the Academy of Clinical Laboratory Physicians and Scientists (ACLPS) June 2006.

Jason Gestwicki was selected for one of the 6 McKnight Foundation's Neuroscience of Brain Disorders Awards for 2007 along with Andrew Lieberman (Dept. of Pathology) and Bill Pratt (Dept. of Pharmacology).

Brian Pfleger, from David Sherman's lab, received a postdoctoral training award through the Great Lakes Regional Center of Excellence for his proposal titled "Discovery of Novel Inhibitors of Anthrachelin Production in Bacillus Anthracis."

Aruna Shankaranarayanan, from John Tesmer's lab, was awarded an AHA Predoctoral Fellowship (2007-2008).

John J.G. Tesmer secured an R01 research grant for "Structural Studies of Gαq and Its Complexes at the Cell Membrane."

PhDs Awarded

Irfan Lodhi of the Saltiel lab defended his thesis in December 2006: "Regulation of Insulin-Stimulated Glucose Transport by Small GTP-Binding Proteins."

Publications

Yukiko M. Yamashita, Anthony P. Mahowald, Julie R. Perlin and Margaret T. Fuller. "Asymmetric inheritance of mother vs. daughter centrosome in stem cell division." Science 315, 518-521 (2007).

Klionsky Lab:

"Recruitment of Atg9 to the preautophagosomal structure by Atg11 is essential for selective autophagy in budding yeast" by Congcong He, Hui Song, Tomohiro Yorimitsu, Iryna Monastyrska, Wei-Lien Yen, Julie E. Legakis, and Daniel J. Klionsky was the cover story of the December 18, 2006 issue of the Journal of Cell Biology.

Tesmer Lab:

Li Q, Nance MR, Kulikauskas R, Nyberg K, Fehon R, Karplus PA, Bretscher A, Tesmer JJG: Self-masking in intact ERM-merlin proteins: an active role for the enigmatic α-helical domain. J. Mol. Biol. 2007, 365: 1446-1459.

Saltiel Lab:

Lumeng, C.N., DeYoung, S.M. and Saltiel, A.R. "Macrophages block insulin action in adipocytes by alter- ing expression of signaling and glucose transport proteins" (2006) Am J Physiol Endocrinol Metab 292, 166 (feature cover article)

Lumeng, C.N., Bodzin, J.L. and Saltiel, A.R. "Obesity induces a phenotypic switch in adipose tissue macrophage polarization" (2007) J. Clin. Invest. 117, 175 (feature cover article)

Sherman and Smith Labs:

Giraldes, J.W., Akey, D.L., Kittendorf, J.D., Sherman, D.H., Smith, J.L., Fecik, R.A. 2006. Structural and mechanistic insights of polyketide macrolactonization from polyketide-based affinity labels. Nature Chemical Biology. 2:531-536.

Akey, D.L., Kittendorf, J.D., Giraldes, J.W., Fecik, R.A., Sherman, D.H., Smith, J.L. 2006. Structural basis for macrolactonization by the pikromycin thioesterase. Nature Chemical Biology. 2:537-542.

Sherman Lab:

"Biosynthetic Characterization and Chemoenzymatic Assembly of the Cryptophycins. Potent Anticancer Agents from Nostoc Cyanobionts" by Magarvey N.A.; Beck Z.Q.; Golakoti T.; Ding Y.; Huber U.; Hemscheidt T.K.; Abelson D.; Moore R.E.; Sherman D.H. was the cover story in the print version of ACS Chemical Biology January, 2007.

Rosenberg Lab:

NA Rosenberg, S Mahajan, C Gonzalez-Quevedo, MGB Blum, L Nino-Rosales, V Ninis, P Das, M Hegde, L Molinari, G Zapata, JL Weber, JW Belmont, PI Patel (2006) "Low levels of genetic divergence across geographically and linguistically diverse populations from India." PLoS Genetics 2: 2052-2061.

DF Conrad, M Jakobsson, G Coop, X Wen, JD Wall, NA Rosenberg, JK Pritchard (2006) A worldwide survey of haplotype variation and linkage disequilibrium in the human genome. Nature Genetics 38: 1251-1260.

Lee Lab:

Cheng-Yu Lee, Ryan O. Andersen, Clemens Cabernard, Laurina Manning, Khoa D. Tran, Marcus J. Lanskey, Arash Bashirullah, and Chris Q. Doe, "Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation," Genes & Dev., Dec 2006; 20: 3464 - 3474; doi:10.1101/gad.1489406

Ginsburg Lab:

Chauhan AK, Motto DG, Lamb CB, Scheiflinger F, Ginsburg D, Wagner DD. "The metalloprotease ADAMTS13 is a natural anti-thrombotic," J Exp Med 203:767-776, 2006.

Seligsohn U and Ginsburg D. "Deciphering the mystery of combined factor V and factor VIII deficiency," J Thromb Haemost 4:927-931, 2006.

Bernat JA, Crawford GE, Ogurtsov AY, Collins FS, Ginsburg D, Kondrashov AS. "Distant conserved sequences flanking endothelial-specific promoters contain tissue specific DNase-hypersensitive sites and over-represented motifs," Hum Mol Med 15:2098-2105, 2006.

Lemmerhirt HL, Shavit JA, Levy GG, Cole SM, Long JC, Ginsburg D. "Enhanced VWF biosynthesis and elevated plasma VWF due to a natural variant in the murine Vwf gene," Blood 108:3061- 3067, 2006.

ThermoFisher Scientific/CCG Pilot Project Awards Announced

In conjunction with LSI, ThermoFisher Scientific is pleased to announce the awards for its second annual Center for Chemical Genomics Pilot Project Initiative. The funds will provide research support for up to two years, allowing U-M scientists to conduct innovative research directed toward technology development relating to high throughput screening, small molecules synthesis, target detection and assay miniaturization. Researchers receiving awards are LSI Research Assistant Professor Jason Gestwicki for "Systematic Generation of Uniformly Modified Drug Libraries"; Professor of Electrical Engineering Jay Guo for "Label-free Optical Micro-Resonator Biosensor for High-throughput Screening Applications"; Assistant Professor of Materials Science and Engineering Jinsang Kim for "Polydiacetylene-based Self-signal Amplifying Protein Sensors and Microarrays"; Assistant Professor of Biomedical Engineering and Chemical Engineering Michael Mayer for "Efficient and Parallel Formation of Membrane Protein Arrays by Hydrogel-based Microcontact Printing", and Professor of Chemistry John Montgomery for "New Methods for Macrocycle Glycosylation."

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