Saltiel Life Sciences Symposium 2024: Celebrating 20 Years of Impact

Kahn Auditorium, Biomedical Science Research Building (BSRB)

Audience This is a public event.

On May 20 and 21, 2024, the LSI will host a special two-day Saltiel Life Sciences Symposium highlighting the impactful science and scientists that have emerged from the LSI’s first 20 years.

Schedule

Day 1: Monday, May 20, 2024

9:00 a.m. | Welcome
Mary Sue Coleman, Ph.D., President Emerita of the University of Michigan
9:15 a.m. | Mary Sue and Kenneth Coleman Life Sciences Lecture:
Genetics of hemostasis — From bedside to bench and back again
David Ginsburg, M.D., U-M Life Sciences Institute
10:10 a.m | Session 1: Biological mechanisms at the finest scale — Insights from structural biology
Session Chair: Janet Smith, Ph.D., U-M Life Sciences Institute
- Chasing G protein-coupled receptors with electron microscopy
  Georgios Skiniotis, Ph.D., Stanford University
- Adapter control mechanisms of the p97/VCP AAA+ unfoldase
  Dan Southworth, Ph.D., University of California, San Francisco
- Structural consequences of receptor barcoding by GRK2 and GRK5
  John Tesmer, Ph.D., Purdue University
- Insights into neurodegeneration by in situ cryo-ET
  Shyamal Mosalaganti, Ph.D., U-M Life Sciences Institute
- Structural basis of mRNA translation initiation and its regulation in eukaryotes
  Jay Brito Querido, Ph.D., U-M Life Sciences Institute
11:55 a.m. | Break
12:10 p.m. | LSI Alumni Talks — Structural Biology
Session Chair: Melanie Ohi, Ph.D., U-M Life Sciences Institute
- Structural dynamics and specificity in RhoGEF signaling
  Jen Cash, Ph.D., University of California, Davis
- Molecular mechanism of IgM
  Junyu Xiao, Ph.D., Peking University
12:45 p.m. | Lunch and Poster Session (View poster titles and authors)
2:15 p.m.| Session 2: Exploring the building blocks of life — Cell and developmental biology
Session Chair: Chelsey Spriggs, Ph.D., U-M Life Sciences Institute
- The hematopoietic stem cell niche: Implications for bone marrow transplantation and regeneration
  Sean Morrison, Ph.D., University of Texas Southwestern Medical Center
- Satellite DNA divergence in speciation
  Yukiko Yamashita, Ph.D., Whitehead Institute, Massachusetts Institute of Technology
- Neutrophil signaling during acute inflammation
  Carole Parent, Ph.D., U-M Life Sciences Institute
- Why does receptor recycling between endosomes and the plasma membrane require multiple parallel pathways?
  Lois Weisman, Ph.D., U-M Life Sciences Institute
3:40 p.m. | Break
3:55 p.m. | The LSI at 20: Origin and Evolution of the Life Sciences Institute
Moderator: Roger Cone, Ph.D., U-M Life Sciences Institute
- Huda Akil, Ph.D., U-M Medical School
- Liz Barry, J.D., Higher Education Consultant
- Mary Sue Coleman, Ph.D., President Emerita of the University of Michigan
- David Ginsburg, M.D., U-M Life Sciences Institute
- Paul Meister, Liberty Lane Partners, LLC
- Alan Saltiel, Ph.D., University of California, San Diego
- David Walt, Ph.D., Wyss Institute at Harvard University, Brigham and Women’s Hospital
5:00 p.m. | Day concludes

Day 2: May 21, 2024

9:00 a.m. | Welcome
9:10 a.m. | Session 3: From cells to systems — The physiology of health and disease
Session Chair: Jun Wu, Ph.D., U-M Life Sciences Institute
- New functions of Notch signaling in B and T cell immunity
  Ivan Maillard, M.D., Ph.D., University of Pennsylvania
- TREM2+ macrophages at the crossroads of metabolic liver disease and cancer
  Jiandie Lin, Ph.D., U-M Life Sciences Institute
- A new mechanism in the regulation of energy homeostasis
  Roger Cone, Ph.D., U-M Life Sciences Institute
10:15 a.m. | Break
10:45 a.m. | LSI Alumni Talks — Physiology
Session Chair: Ken Inoki, M.D., Ph.D., U-M Life Sciences Institute
- Scrambling in membrane balance and metabolic homeostasis
  Xiao-Wei Chen, Ph.D., Peking University
- Phasic/tonic glial GABA differentially transduce for olfactory adaptation and neuronal aging
  Lijun Kang, Ph.D., Zhejiang University
- Fishing for novel diagnostics and therapeutics for blood and cardiovascular disorders
  Jordan Shavit, M.D., Ph.D., U-M Medical School
11:35 a.m. | Lunch Break
12:30 p.m. | Session 4: Untangling the complexity of the nervous system — New frontiers in neuroscience
Session Chair: Cheng-Yu Lee, Ph.D., U-M Life Sciences Institute
- Decoding neuronal diversity: Tracking molecular changes along lineage progression
  Tzumin Lee, M.D., Ph.D., U-M Life Sciences Institute
- Neural control circuits of breathing patterns
  Peng Li, Ph.D., U-M Life Sciences Institute
- Protein-based sensors and tools for studying neuromodulatory systems
  Wenjing Wang, Ph.D., U-M Life Sciences Institute
- How do we sense the world? Lessons from the worm
  Shawn Xu, Ph.D., U-M Life Sciences Institute
1:55 p.m.| Break
2:05 p.m. | Session 5: Catalyzing discovery — Innovation at the intersection of chemistry and biology
Session Chair: Anna Mapp, Ph.D., U-M Life Sciences Institute
- (I’m still trying to) Target protein stability to treat neurodegenerative diseases
  Jason Gestwicki, Ph.D., University of California, San Francisco
- Making connections between protein sequence space and chemical space
  Alison Narayan, Ph.D., U-M Life Sciences Institute
- Discovery and engineering of natural product molecules for drug discovery
  David Sherman, Ph.D., U-M Life Sciences Institute
- Ultrasensitive single-molecule detection platforms for biomarker discovery and beyond
  Connie Wu, Ph.D., U-M Life Sciences Institute
3:30 p.m. | Break
3:40 p.m. | Session 6: Computation & Artificial Intelligence in Life Sciences
Session Chair: Jun Li, Ph.D., U-M Medical School
- Mathematical and computational studies in human population genetics
  Noah Rosenberg, Ph.D., Stanford University (video)
- AI-based behavioral analysis for life sciences
  Bing Ye, Ph.D., U-M Life Sciences Institute (video)
- Algorithms to automate cryo-EM data collection
  Mike Cianfrocco, Ph.D., U-M Life Sciences Institute
4:40 p.m.| Closing Remarks